A5011405524- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- Congenital heart defects research
- Heat shock proteins research
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
- Sarcoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Enzyme Structure and Function
- Liver Disease Diagnosis and Treatment
University of Chinese Academy of Sciences
2025
Hainan Medical University
2025
Shanghai Institute of Nutrition and Health
2025
Brock University
2015-2024
People's Hospital of Shiyan
2024
Shaanxi University of Science and Technology
2024
Nanjing University of Chinese Medicine
2024
Nanjing Second Hospital
2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into large chromosome 2 related minichromosomes. The NRC-1 codes for 2,630 predicted proteins, 36% which are unrelated to any previously reported. Analysis shows presence pathways uptake utilization amino acids, active sodium-proton antiporter potassium systems, sophisticated photosensory signal...
Abstract Summary:The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria–Delbrück fluctuation analysis to calculate the frequency and rate from various mutation assays in bacteria yeast. Three calculation methods are available through this program: (i) Ma-Sandri-Sarkar Maximum Likelihood Estimator (MSS-MLE) method, (ii) Lea-Coulson method of median (LC) (iii) frequency. Availability: The FALCOR calculator currently accessible at...
Abstract Peroxiredoxin 1 (Prx1) has been found to be elevated in several human cancers. The cell survival–enhancing function of Prx1 is traditionally attributed its reactive oxygen species–removing capacity, although the growth-promoting role independent this antioxidant activity increasingly gaining attention. Although much progress made understanding behavior Prx1, little information available on mechanism responsible for abnormal elevation level cancer. We hypothesized that hypoxic and...
Retrotransposons constitute over 40% of the human genome and play important roles in evolution genome. Since certain types retrotransposons, particularly members Alu, L1, SVA families, are still active, their recent ongoing propagation generates a unique class genomic diversity/polymorphism (for presence absence an insertion) with some elements known to cause genetic diseases. So far, 2,300, 500, 80 insertions, respectively, have been reported be polymorphic many more yet discovered. We...
The Warburg Effect is characterized by an irreversible injury to mitochondrial oxidative phosphorylation (OXPHOS) and increased rate of aerobic glycolysis. In this study, we utilized a breast epithelial cell line lacking DNA (rho0) that exhibits the associated with cancer. We developed MitoExpress array for rapid analysis all known nuclear genes encoding proteome. gene-expression pattern was compared among normal line, its rho0 derivative, cancer lines primary tumors. Among several genes,...
Changes in DNA methylation the mammalian genome during development are frequent events and play major roles regulating gene expression other developmental processes. It is necessary to identify these so that we may understand how changes affect normal aberrant impact disease.In this study Methylated ImmunoPrecipitation (MeDIP) was used conjunction with a NimbleGen promoter plus CpG island (CpGi) array Tissue Developmental Stage specific Differentially Regions (T-DMRs DS-DMRs) on genome-wide...
In the polyamine back-conversion pathway, spermine and spermidine are first acetylated by spermidine/spermine N1 -acetyltransferase (SSAT) then oxidized oxidase (PAO) to produce putrescine respectively. Although PAO was purified more than two decades ago, protein has not yet been linked genomic sequences. present study, we apply a BLAST search strategy identify novel sequences located on human chromosome 10 mouse 7. Homologous mammalian cDNAs derived from brain mammary tumour were deduced...
With more than 1.2 million copies, Alu elements are one of the most important sources structural variation in primate genomes. Here, we compare chimpanzee and human genomes to determine extent recombination-mediated deletion (ARMD) genome since divergence lineages (∼6 y ago). Combining computational data analysis experimental verification, have identified 663 lineage-specific deletions (involving a total ∼771 kb genomic sequence) attributable this process. The ARMD events essentially...
Mobile elements (MEs) collectively contribute to at least 50% of the human genome. Due their past incremental accumulation and ongoing DNA transposition, MEs serve as a significant source for both inter- intra-species genetic phenotypic diversity during primate evolution. By making use most recent genome sequences many other closely related primates robust multi-way comparative genomic approach, we identified total 14,870 human-specific (HS-MEs) with more than 8,000 being newly identified....
L1 retrotransposons can pose a threat to genome integrity. The host has evolved restrict replication. However, mechanisms underlying propagation out of the surveillance remains unclear. Here, we propose an evolutionary survival strategy L1, which exploits RNA m6A modification. We discover that 'writer' METTL3 facilitates retrotransposition, whereas 'eraser' ALKBH5 suppresses it. essential cluster is located on 5' UTR serves as docking site for eukaryotic initiation factor 3 (eIF3), enhances...
Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions sequence-similar proteins has become available. On basis this new information, an updated version chromosome been generated.The E. is currently represented by 4,401 genes encoding 116 RNAs 4,285 proteins. The boundaries identified GenBank Accession U00096 were used. Some protein-coding sequences are compound encode multimodular coding...
Encysted brine‐shrimp gastrulae bring their metabolism to a reversible standstill during diapause and quiescence, demonstrating remarkable resistance unfavourable environmental conditions. For example, mortality of Artemia embryos under normal temperature hydration is very low, even after two years anoxia, commonly experience complete desiccation as part developmental program. Previous evidence from our laboratories indicated that p26, an abundant low‐molecular‐mass cyst‐specific protein...
Lung epithelial cells are primary targets of oncostatin M (OSM) and, to a lower degree, interleukin (IL)-6 and IL-31, all members the IL-6 cytokine family. The OSM receptor (OSMR) signals through activation STAT mitogen-activated protein kinase pathways induce genes encoding differentiated cell functions, reduce cell-cell interaction, suppress proliferation. IL-31 functions heteromeric receptor, which shares with OSMR OSMRbeta subunit, but does not engage gp130, common subunit other...
Abstract Multiple genetic loci contribute to the development of systemic lupus erythematosus (SLE). In murine models for SLE, various genes on chromosome four have been implicated. IL-14 is a cytokine originally identified as B cell growth factor. The il14 gene located 4. IL-14α encoded by plus strand using exons 3–10. expression increased in (NZB × NZW)F1 mice. this study, we produced IL-14α-transgenic mice study role autoimmunity. At age 3–9 mo, demonstrate numbers B1 cells peritoneum,...