A5101459325- Chronic Kidney Disease and Diabetes
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory viral infections research
- Lung Cancer Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Gastric Cancer Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Peptidase Inhibition and Analysis
- Pediatric Urology and Nephrology Studies
- Bladder and Urothelial Cancer Treatments
- Hernia repair and management
- Lung Cancer Research Studies
- Pelvic floor disorders treatments
- Pediatric health and respiratory diseases
- Galectins and Cancer Biology
Zhengzhou University
2018-2025
Henan Cancer Hospital
2018-2025
Beijing Children’s Hospital
2024-2025
Capital Medical University
2024-2025
Northwest Women's and Children's Hospital
2017-2024
Shanghai Institute of Hematology
2015-2024
Sun Yat-sen University
2016-2023
Zhongshan Hospital
2015-2023
Fudan University
2015-2023
The First Affiliated Hospital, Sun Yat-sen University
2019-2023
Abstract Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts proteolytic activities of cysteine proteases. CST1 has been recently considered be involved in development several human cancers. However, prognostic significance and function breast cancer remains unknown. In current study, we found that was generally upregulated at both mRNA protein level. Furthermore, overall survival (OS) disease-free (DFS) low expression subgroup were significantly superior...
Background: Currently, there are no molecular biomarkers for the early detection of non-small-cell lung cancer (NSCLC). This study focused on identifying RNAs found tumor-educated blood platelets (TEPs) detecting stage I NSCLC. Methods: Platelet RNAs, isolated from 9 patients with NSCLC (stages and II) 8 healthy controls, were analyzed using RNA-seq. ITGA2B was selected as a candidate marker. Two different Polymerase Chain Reactions (PCR) used to measure in platelet samples controls (n =...
To evaluate whether serum Cathepsin S (Cat S) could serve as a biomarker for the diagnosis and prognosis of gastric cancer (GC), Enzyme-linked immuno sorbent assay (ELISA) was used to detect Cat in 496 participants including healthy controls patients with benign diseases, cancer, esophageal liver colorectal nasopharyngeal lung cancer. The levels were significantly increased patients, especially GC patients. qRT-PCR, Western blotting, immunohistochemical staining revealed overexpression cell...
Abstract Dexmedetomidine (DEX) is an anesthetic that widely used in the clinic, and it has been reported to exhibit paradoxical effects progression of multiple solid tumors. In this study, we sought explore mechanism by which DEX regulates hepatocellular carcinoma (HCC) underlying liver fibrosis. We determined on tumor orthotopic HCC mouse model fibrotic liver. A coculture system a subcutaneous xenograft involving coimplantation hepatoma cells (H22) primary activated hepatic stellate (aHSCs)...
Circular RNA (circRNA/circ)‑ubiquitin associated protein 2 (UBAP2), a newly recognized circRNA, serves functional role in several types of tumor, including ovarian cancer, colorectal cancer and osteosarcoma. However, the precise roles molecular mechanism underlying circUBAP2 osteosarcoma (OS) are not completely understood. In present study, expression levels circUBAP2, microRNA (miR)‑204‑3p (HMGA2) were evaluated via reverse transcription‑quantitative PCR OS tissues cells. cell...
Lower respiratory tract infections (LRTIs) are one of the leading causes hospitalization in children, with their associated pathogens typically following seasonal epidemic patterns. However, COVID-19 pandemic has profoundly altered landscape pediatric infections, causing unprecedented shifts epidemiology common pathogens. To date, long-term epidemiological surveillance remains limited, particularly populations. We aimed to investigate dynamic changes etiologies hospital admissions for...
Background This study aimed to construct a novel model and validate its predictive power in non-esophageal squamous cell carcinoma (NESCC) patients.
Glutamate is well-known as metabolite for maintaining the energy and redox homeostasis in cancer, moreover it also primary excitatory neurotransmitter central nervous system. However, whether glutamatergic signaling can regulate hepatocellular carcinoma (HCC) progression specific regulatory mechanisms are unknown. In present study, we found that glutamate its receptor NMDAR2B were significantly elevated HCC patients, which predicts poor prognosis. could upregulate CCL2 expression on hepatoma...
Purpose: This study aimed to develop an effective nomogram for predicting survival in surgically treated non-small cell lung cancer patients.Methods: We retrospectively evaluated 856 NSCLC this study.Cox regression analyses were performed identify significant prognostic factors developing a predict overall (OS).The discriminative ability was assessed with the concordance index (C-index).Results: On multivariate analysis of cohort, independent CRP, fibrinogen, tumor status, nodal distant...
The purpose of this work is to analyze preoperative serum aspartate aminotransferase (AST) levels and their effect on the prognosis patients with non-small cell lung cancer (NSCLC) after surgical operation. These analyses were performed retrospectively in NSCLC followed by surgery; participants recruited between January 2004 2008. All clinical information laboratory results collected from medical records. We explored association AST recurrence-free survival (RFS), overall (OS) patients....
Using the TMN classification alone to predict survival in patients with gastric cancer has certain limitations, we conducted this study was develop an effective nomogram based on aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio overall (OS) surgically treated cancer.we retrospectively analyzed 190 cases of and used Cox regression analysis identify significant prognostic factors for OS resectable cancer. The predictive accuracy assessed using a calibration plot, concordance...
Solar thermal cooling is one of the best promised technologies to get from sun. The main obstacle promoting this technology its high initial cost and low efficiency. Nowadays more evacuated tube collectors can work at temperature up 90˚C with efficiency no less than 40%. At same time, absorption chillers driven by heat medium lower 90 ˚C are emerging in China. This paper presents a novel solar system applied typical office building 50RT normal Chinese store both heating simultaneously. has...
This study aimed to provide data for the clinical features of invasive pneumococcal disease (IPD) and molecular characteristics
Abstract Purpose It is generally accepted that long noncoding RNAs (lncRNAs) function as vital regulators of tumor development and progression. Long intergenic non‐coding RNA 1410 (LINC01410) a newly discovered lncRNA, its role in osteosarcoma (OS) yet to be determined. Materials methods The expression LINC01410, microRNA‐122‐5p (miR‐122‐5p), N‐myc downstream‐regulated gene 3 (NDRG3) OS tissues was determined using reverse transcription‐quantitative PCR. Interactions between miR‐122‐5p,...
To investigate the predictive value of chemokine CCL27 for identifying early stage nasopharyngeal carcinoma (NPC) patients within a population seropositive Epstein-Barr virus (EBV) capsid antigen-specific IgA (VCA-IgA). in plasma samples from 104 NPC patients, 112 VCA-IgA–positive healthy donors, and 140 VCA-IgA–negative normal subjects was measured by ELISA. Expression tissue 20 donors examined immunohistochemical staining. Levels (607.33 ± 218.81 pg/ml) were significantly higher than...
The primary objective of this study is to develop a new constitutive model by combining fractional‐order Kelvin–Voigt with an Abel dashpot element in parallel. Subsequently, will be incorporated into the Euler–Bernoulli beam's governing equation, utilizing shifted Legendre polynomials as basis functions, classical orthogonal polynomial system, solve partial differential equations. By comparing numerical solutions analytical solutions, we aim evaluate applicability solving such problems and...
The 2017 high blood pressure (BP) clinical practice guideline reported by the American College of Cardiology/American Heart Association put forward new categories BP. This study aimed to assess applicability in a nondialysis chronic kidney disease (CKD) population.This is nationwide, multicenter, cross-sectional with large sample. A total 8927 CKD patients 61 tertiary hospitals all 31 provinces, municipalities and autonomous regions China (except Hong Kong, Macao Taiwan) were analyzed. BP...
Background: Serum lipids have been documented as prognostic biomarkers in several types of cancer, however the value serum non-esophageal squamous cell carcinoma (non-ESCC) is not clear. The purpose this study was to investigate roles non-ESCC and establish a novel effective nomogram for overall survival (OS) disease-free (DFS) patients with non-ESCC. Methods: We retrospectively analyzed values pretreatment lipids, including total cholesterol (TC), triglycerides (TG), high-density...
Chronic inflammation plays an important role in tumor progression.The aim of this study was to develop effective predictive dynamic nomogram integrated with inflammation-based factors predict overall survival (OS) non-small cell lung cancer (NSCLC) patients chronic hepatitis B viral (HBV) infection.We retrospectively analyzed NSCLC HBV infection from Sun Yat-sen University Cancer Center between 2008 and 2010.Univariate multivariate Cox analyses were performed identify prognostic associated...
BACKGROUND The aim of this study was to determine the risk factors for early chronic kidney disease (CKD) (GFR 60-89 ml/min/1.73 m²; CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination. MATERIAL AND METHODS This cross-sectional enrolled 9100 who received voluntary medical examinations between 10/01/2011 and 09/30/2017. Demographic data, clinical history, examination, medication, smoking, alcohol, blood biochemistry, urinalysis, carotid ultrasound were...