A5026446016- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal Diseases and Glomerulopathies
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- Medical Research and Treatments
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Immune cells in cancer
- Erythropoietin and Anemia Treatment
- Systemic Lupus Erythematosus Research
- Iron Metabolism and Disorders
- Renal function and acid-base balance
- IL-33, ST2, and ILC Pathways
- Health and Wellbeing Research
Zhongshan Hospital
2014-2024
Fudan University
2011-2024
Shanghai Medical Information Center
2024
Shanghai Institute of Hematology
2014-2024
Sun Yat-sen University
2005-2024
Shanghai Medical College of Fudan University
2000-2024
Shanghai Blood Center
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2005-2024
Food and Drug Administration
2022
Zhongshan Hospital of Xiamen University
2022
Abstract Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. We identify TRAF2- and NCK-interacting kinase (TNIK) as anti-fibrotic target using predictive artificial intelligence (AI) approach. Using AI-driven methodology, we generated INS018_055, small-molecule TNIK inhibitor, which exhibits desirable drug-like properties activity...
<b><i>Aims:</i></b> This study aimed to assess risk factors of intradialytic hypotension (IDH) and the association prognosis IDH among maintenance hemodialysis (MHD) patients. <b><i>Methods:</i></b> Among 293 patients, 117 were identified with (more than 4 hypotensive events during 3 months). The between survival was evaluated. <b><i>Results:</i></b> incidence 39.9%. Age, ultrafiltration rate, N-terminal pro-B-type...
Abstract Chronic kidney disease (CKD) is a global health burden, with ineffective therapies leading to increasing morbidity and mortality. Renal interstitial fibrosis common pathway in advanced CKD, resulting function structure deterioration. In this study, we investigate the role of FTO‐mediated N6‐methyladenosine (m6A) its downstream targets pathogenesis renal fibrosis. M6A modification, prevalent mRNA internal has been implicated various organ processes. We use mouse model unilateral...
MicroRNA-21 (miR-21) is one of the most frequently upregulated miRNAs in response to kidney ischemia-reperfusion (IR) injury, exhibiting both protective and pathogenic effects depending on cell type, disease state, target signaling. In this study, we analyzed function miR-21 various types elucidate its role ischemia-induced inflammation acute injury (AKI). Utilizing a mouse model IR observed significant upregulation renal tubular epithelial cells macrophages following IR. Deletion mitigated...
Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease (CKD) patients are limited. The aim present study was to investigate prevalence, awareness, treatment, and control CKD through a nationwide, multicenter China. Methods survey performed 61 tertiary hospitals 31 provinces, municipalities, autonomous regions China (except Hong Kong, Macao, Taiwan). Trained physicians collected demographic clinical data measured blood pressure (BP) using...
<b><i>Introduction:</i></b> The mortality of peritoneal dialysis (PD) patients remains high. neutrophil to lymphocyte ratio (NLR), as an indicator systemic inflammation, has been considered be a predictor cardiovascular and all-cause in hemodialysis patients. present study aims investigate the relationship between NLR long-term outcome PD <b><i>Materials Methods:</i></b> included who initiated for at least 3 months January 1, 2013, December 31,...
Abstract The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism crosstalk cells in pathogenesis progression remains unexplored. In our research, we performed non-negative matrix decomposition (NMF) algorithm on single-cell RNA sequencing data based specifically focusing ferroptosis-associated genes. Through combination with pseudo-time analysis, cell–cell interaction analysis SCENIC...
Abstract Background Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of immune system, which is recently concerned as significant factor for increased risk various morbidities. Nevertheless, there are few dates explicating the relevancy T cell senescence to mortality. In this study, we prospectively studied predictive value mortality in hemodialysis patients. Methods who had been on treatment at least 6 months were enrolled. determined by differentiation...
Abstract The aim of this study is to investigate the effects endogenous vasoactive substances on occurrence intradialytic hypertension ( IDH ) in patients during maintenance hemodialysis. Thirty‐four hemodialysis were enrolled trial, and 17 them diagnosed with (defined as an increase blood pressure at least 10 mmHg or immediately after a session), while age‐matched sex‐matched controls without selected for retrospective comparison. We collected patients' samples before dialysis session...
Objective The aim of this study was to investigate the effects two different treatment regimes in patients with IgA nephropathy (IgAN): steroids alone and combination a medium dose cyclosporine A (CsA). Methods Forty-eight IgAN 18-69 years age proteinuria >1.0 g/24 hours an estimated glomerular filtration rate (eGFR) >30 mL/min/1.73 m2 were randomly given either (methylprednisolone (MP) group; n=25) or plus CsA (combination n=23). primary endpoint reduction by 50% more baseline value....
Introduction: N-terminal-pro-brain natriuretic peptide (NT-pro BNP) is secreted by cardiomyocytes in cases of cardiac structure disorder and volume overload. However, the relationship between NT-pro BNP level body fluid status dialysis patients with reduced ejection function (EF) uncertain. Therefore, we aimed to investigate this relationship. Methods: We enrolled who had been receiving hemodialysis for &gt;3 months. Blood sample, transthoracic echocardiographic, bioimpedance...
Introduction: Chronic inflammation and immune system dysfunction have been evaluated as major factors in the pathogenesis of chronic kidney disease (CKD), contributing to high mortality rates observed these populations. Uremic toxins seem be potential "missing link." Indoxyl sulfate (IS) is one protein-bound renal toxins. It participates multiple pathologies CKD complications, yet its effect on cell has not studied. This study aimed explore genome-wide expression profile human peripheral...
Background Intradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate potential role IDH.Methods MHD patients starting before January 2016 were enrolled our retrospective study. Patients' characteristics, laboratory results, intradialytic BP collected. IDH was defined as...
Intradialytic-hypotension (IDH) is a common complication of hemodialysis. High ultrafiltration rate (UFR) might lead to IDH. However, the relationships between UFR, IDH, and cardiac remodeling among hemodialysis patients in long-term have not been deeply explored.This retrospective cohort study collected clinical echocardiographic data. Patients were enrolled from 1 January 2014 31 March followed-up for 5-year. Those who suffered more than four hypotensive events during three months (10%...
Ribosomal protein S6 (rpS6) phosphorylation mediates the hypertrophic growth of kidney proximal tubule cells. However, role rpS6 in podocyte hypertrophy and loss during pathogenesis focal segmental glomerulosclerosis (FSGS) remains undefined. Here, we examined levels biopsy specimens from patients with FSGS podocytes mouse kidneys Adriamycin-induced FSGS. Using genetic pharmacologic approaches model FSGS, investigated development progression Phosphorylated was found to be markedly increased...
The 2017 high blood pressure (BP) clinical practice guideline reported by the American College of Cardiology/American Heart Association put forward new categories BP. This study aimed to assess applicability in a nondialysis chronic kidney disease (CKD) population.This is nationwide, multicenter, cross-sectional with large sample. A total 8927 CKD patients 61 tertiary hospitals all 31 provinces, municipalities and autonomous regions China (except Hong Kong, Macao Taiwan) were analyzed. BP...
Objective: Left ventricular hypertrophy (LVH) is the strongest predictor of cardiovascular mortality, leading cause death in hemodialysis (HD) patients. This study aims to identify potential risk factors for LVH HD Methods: Exactly, 164 patients (84 men and 80 women) who had been on treatment at least 6 months were enrolled. Clinical data collected. Anthropometric measurements, biochemical analyses, echocardiography performed. The determined by multivariate linear logistic regression....
We aimed to investigate the relationship between perioperative hemodynamic parameters and occurrence of cardiac surgery-associated acute kidney injury.A retrospective study was performed in patients who underwent surgery at a tertiary referral teaching hospital. Acute injury determined according KDIGO criteria. investigated association identify independent predictors for injury. Subgroup analysis further with chronic hypertension.Among 300 patients, 29.3% developed during postoperative...
<b><i>Background/Aims:</i></b> To compare the serum concentration of Indoxyl sulfate (IS) in patients on continuous ambulatory peritoneal dialysis (CAPD) and low-flux hemodialysis (HD), analyze risk factors associated with IS. <b><i>Methods:</i></b> We performed a single-center, cross-sectional observational study including 169 CAPD 115 HD. Patients were divided into anuric HD group, (PD) non-anuric PD group basis modality residual urinary...
Renal ischaemia/reperfusion injury (IRI) is a complication of major surgeries. Regulatory T cells (Tregs) can suppress immunologic damage in the renal IR. Previous studies indicated that delayed ischaemic preconditioning (IPC) partially attenuates IR by inducing Treg expansion. Galectin-9 also inflammation-related organ expanding Tregs, but it was not used yet. Our aim to test whether IPC combined with galectin-9 has an increased renoprotective effect.Mice were divided into five treatment...