A5037203530- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Renal and related cancers
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Inflammasome and immune disorders
- Muscle and Compartmental Disorders
- Drug Transport and Resistance Mechanisms
- Organ Transplantation Techniques and Outcomes
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
- Eicosanoids and Hypertension Pharmacology
- Respiratory Support and Mechanisms
- Chemotherapy-induced organ toxicity mitigation
- Kruppel-like factors research
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory and Cough-Related Research
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Traditional Chinese Medicine Analysis
- Acupuncture Treatment Research Studies
- Marine Invertebrate Physiology and Ecology
- Pregnancy and Medication Impact
Third Hospital of Hebei Medical University
2023-2025
Hebei Medical University
2023-2025
Tongde Hospital of Zhejiang Province
2024
Hospital of Hebei Province
2024
Fudan University
2019-2023
Zhongshan Hospital
2019-2023
Shanghai Institute of Hematology
2019-2023
Xiyuan Hospital
2023
China Academy of Chinese Medical Sciences
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Acute kidney injury (AKI) is a life-threatening condition that one of most common side effects cisplatin therapy. Fatty acid oxidation (FAO) the main source energy production in proximal tubular epithelial cells (PTECs) but it inhibited AKI. Recent work demonstrated activation farnesoid X receptor (FXR) protects against AKI, underlying mechanism remains elusive. Using model cisplatin-induced we found FXR and FAO-related genes were remarkably downregulated while lipid accumulated. Proximal...
BackgroundUncoupling protein 1 (UCP1) is predominantly found in brown adipose tissue mitochondria, and mediates energy dissipation to generate heat rather than ATP via functional mitochondrial uncoupling. However, little known about its expression function kidney.MethodsWe carried out a mRNA microarray analysis mice kidneys with ischemia reperfusion (IR) injury. The most dramatically downregulated gene UCP1 after IR was identified, role generation of reactive oxygen species (ROS) oxidative...
This study provides a mechanistic insight into how C-C motif chemokine ligand 2 (CCL2) is upregulated in renal tubular epithelial cells (TECs) and contributes to kidney dysfunction during sepsis. The data reveal that lipopolysaccharide induces CCL2 expression through the Toll-like receptor 2/NF-κB signaling pathway TECs. Endogenous released from TECs, not myeloid cells, responsible for sepsis-induced inflammation acute injury.
Acute kidney injury (AKI) is a serious condition with high mortality. The most common cause ischemia/reperfusion (IR) injury, which thought to be closely related pyroptosis. Disulfiram well-known alcohol abuse drug, and recent studies have shown its ability mitigate pyroptosis in mouse macrophages. This study investigated whether disulfiram could improve IR-induced AKI elucidated the possible molecular mechanism. We generated an IR model kidneys hypoxia/reoxygenation (HR) murine tubular...
Ischemia-reperfusion injury (IRI) is the main cause of acute kidney (AKI), and there no effective therapy. Microenvironmental acidification generally observed in ischemic tissues. Acid-sensing ion channel 1a (ASIC1a) can be activated by a decrease extracellular pH which mediates neuronal IRI. Our previous study demonstrated that, ASIC1a inhibition alleviates renal However, underlying mechanisms have not been fully elucidated. In this study, we determined that tubule-specific deletion mice...
Abstract Background Researches have used intra-compartmental infusion and ballon tourniquest to create high pressure in animal models of Acute Compartment Syndrome (ACS). However, due the large differences modeling methods evaluation criteria ACS, further researches its pathophysiology pathogenesis are hindered. Currently, there is no ideal model for ACS this study aimed establish a reproducible, clinically relevant model. Methods Blunt trauma fracture were caused by free falling weights...
Significance As a ligand-activated transcription factor, farnesoid X receptor (FXR) is abundantly expressed in the liver and small intestine, where it plays an important role maintenance of bile acid, lipid, glucose homeostasis. Increasing evidence emerging that FXR may be critical regulatory factor renal physiology pathophysiology. The present study demonstrates essential promoting cell survival medullary collecting duct cells under hypertonic stress identifies FXR-induced TonEBP expression...
Abstract Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play an important role in several pathogenic processes of the kidney. However, functions lncRNAs ischemic acute kidney injury (AKI) remain undefined. In this study, global lncRNA profiling indicated many transcripts were deregulated after ischemia reperfusion (IR). Among them, we identified IRAR (ischemia- r eperfusion a ssociated R NA) as potential candidate, which was mostly expressed by tubular epithelial cells...
Lipopolysaccharide (LPS)-induced septic acute kidney injury (AKI) is determined as a devastating organ dysfunction elicited by an inappropriate response to infection with high morbidity and mortality rates. Previous evidence has illustrated indispensable role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) in the pathogenesis sepsis-induced multiorgan abnormalities. Specifically, this study investigated potential ALDH2 AKI. After LPS administration, we observed significant decline renal...
Abstract The delicate balance between bone formation by osteoblasts and resorption osteoclasts maintains homeostasis. Nuclear receptors (NRs) are now understood to be crucial in physiology pathology. However, the function of Farnesoid X receptor (FXR), a member NR family, regulating homeostasis remains incompletely understood. In this study, vitro vivo models revealed delayed development an osteoporosis phenotype mice lacking FXR marrow mesenchymal stem cells (BMSCs) due impaired osteoblast...
Aristolochic acid nephropathy (AAN) is a type of drug-induced and correlated with potentially progression kidney fibrosis. However, whether miR-382 implicated in macrophage activation AA-induced fibrosis remains elusive. Here, cell-sorting experiments defined significant enrichment renal after AAN 14 days. Then, we found that treatment AA induced switch the phenotype both vivo vitro . Furthermore, knockout (KO) mice -/- bone marrow-derived (BMDM) were subjected to induction. We systemic KO...
Myocardial ischemia/reperfusion injury (MI/RI) is involved in a variety of pathological states for which there no effective treatment exists. Shuangshen Ningxin (SSNX) capsule developed by Xiyuan Hospital, Chinese Academy Traditional Medicine has been demonstrated to alleviate MI/RI, but its mechanism remains be further elucidated.The MI/RI miniature pigs model was constructed assess the pharmacodynamics SSNX blocking proximal blood flow left anterior descending branch cardiac coronary...
Dendritic cells (DCs) play an important role in the pathophysiology of renal ischemia-reperfusion injury (IRI). The mechanisms underlying DCs phenotypic modulation and their function are not fully understood. In this study, we examined effect miR-21 on vitro vivo, further investigated impact miR-21-overexpression DC or miR-21-deficient IRI. We found that treatment with hypoxia/reoxygenation (H/R) suppressed expression bone marrow-derived dendritic (BMDCs), significantly increased percentage...
Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, specific mechanism aldosterone-induced injury in progress CKD requires elucidation. Emerging evidence has demonstrated that absent melanoma 2 (AIM2)-mediated inflammasome activation endoplasmic reticulum stress (ERS) play a pivotal role fibrosis. Here, we investigated whether overexpression or deficiency AIM2 affects ERS aldosterone-infused injury. Interestingly, found was markedly expressed...
ObjectivesCumulative fluid overload may influence acute kidney injury (AKI) diagnosis due to the dilution effect. The authors hypothesized a small increase of early postoperative serum creatinine (SCr) adjusted for balance might have superior discrimination ability in subsequent AKI prediction.DesignRetrospective analyses.SettingA single-center study university hospital.ParticipantsThe comprised 1,016 adult patients who underwent elective isolated or combined valve surgery...
Research have shown that sleep is associated with renal function. However, the potential effects of duration or quality on kidney function in middle-aged and older Chinese adults normal has rarely been studied. Our study aimed to investigate association adults. Four thousand eighty six participants an eGFR ≥60 ml/min/1.73 m 2 at baseline were enrolled between 2011 2015 from China Health Retirement Longitudinal Study. Survey questionnaire data collected conducted interviews 2011. The was...
Cisplatin is an anticancer agent marred by nephrotoxicity. Limiting this adverse effect may allow the use of higher doses to improve its efficacy. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis and repair renal diseases. BIO, small molecule agonist pathway, exerted protective adriamycin nephropathy promoted nephrogenesis. aim study, therefore, was investigate whether BIO could protect against cisplatin-induced nephrotoxicity vivo vitro, as well possible mechanism....
Renal ischemia-reperfusion (I/R) can induce oxidative stress and injury via the generation of reactive oxygen species (ROS). proximal tubular cells are susceptible to stress, dysregulation renal cellular homeostasis damage apoptotic pathways. A recent study showed that ROS increase perilipin 2 (Plin2) expression in HepG2 cells. Some evidence has also demonstrated association between Plin2 tumors. However, underlying mechanism I/R-induced acute kidney (AKI) remains elusive. Here, using a...
Abstract Acute kidney injury (AKI) is a common clinical dysfunction with complicated pathophysiology and limited therapeutic methods. Renal tubular the following regeneration process play vital role in course of AKI, but underlining molecular mechanism remains unclear. In this study, network-based analysis online transcriptional data human found that KLF10 was closely related to renal function, various diseases. Three classical mouse models confirmed downregulation AKI its correlation...
We aimed to investigate the relationship between perioperative hemodynamic parameters and occurrence of cardiac surgery-associated acute kidney injury.A retrospective study was performed in patients who underwent surgery at a tertiary referral teaching hospital. Acute injury determined according KDIGO criteria. investigated association identify independent predictors for injury. Subgroup analysis further with chronic hypertension.Among 300 patients, 29.3% developed during postoperative...
Abstract Background Fluid overload is related to the development and prognosis of cardiac surgery-associated acute kidney injury (CSA-AKI). The study investigate influence serum creatinine (SCr) corrected by fluid balance on patients with surgery. Methods A retrospective was conducted in 1334 who underwent elective surgery from January 1 December 31, 2015. Kidney Disease: Improving Global Outcomes (KDIGO) criteria for AKI were applied identify CSA-AKI. SCr measured every 24 h during ICU...
Background: Acute kidney injury (AKI) is a common clinical syndrome with limited methods of treatment and diagnosis. Although several molecules associated AKI have been discovered, molecular mechanisms underlying still remain unclear. Weighted gene co-expression network analysis (WGCNA) novel method to uncover the relationship between genes traits at system level. Methods: First, by employing WGCNA in transcriptional data on 30 patients well/poor functioning graft, we identified two modules...
Background: Dendritic cells (DCs) play an important role in the pathophysiology of immune-mediated kidney diseases, including renal ischemia reperfusion injury (IRI). The phenotypic modulation DCs and their function ischemia-induced acute (AKI) are not fully understood.Methods: Bone marrow-derived dendritic (BMDCs) isolated from mice were treated with hypoxia/reoxygenation (H/R). In vivo, subjected to IRI. DC phenotype pro-inflammatory cytokines expression analyzed. To examined effect miR-21...