A5067242425- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Parkinson's Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- ATP Synthase and ATPases Research
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Phagocytosis and Immune Regulation
- Genomics and Chromatin Dynamics
- Graphene and Nanomaterials Applications
- Trace Elements in Health
- CRISPR and Genetic Engineering
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Antimicrobial agents and applications
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
Institute of High Energy Physics
2016-2025
Chinese Academy of Sciences
2014-2025
University of Chinese Academy of Sciences
2012-2025
Tianjin Medical University General Hospital
2023-2025
Fudan University
2011-2024
Huashan Hospital
2024
Jimei University
2024
Changchun Institute of Optics, Fine Mechanics and Physics
2023
Second Military Medical University
2023
Shanghai Changzheng Hospital
2023
ABT-737 is a novel and potent Bcl-2 antagonist with single-agent activity against small-cell lung cancer (SCLC) cell lines. Here, we evaluated the contribution of family members to in vitro cellular response several SCLC lines ABT-737. Relatively higher levels Bcl-2, Bcl-X(L), Bim Noxa, lower Mcl-1 characterized naïve that were sensitive Conversely, progressive decrease relative Noxa increase increased resistance H146 cells following chronic exposure Knockdown small interfering RNA...
This study develops novel pH and reduction dual-sensitive micelles for the anticancer drug doxorubicin (DOX) delivery owing to fact that tumor tissues show low high environment. These sub-100 nm present a core-shell structure under physiological conditions, but quickly release loaded drugs responding acidic reductive stimuli. With disulfide bonds in each repeat unit of poly(β-amino ester)s, copolymer was synthesized via Michael addition polymerization from 2,2'-dithiodiethanol diacrylate,...
A single-phase white light phosphor, Gd 2 Sr 3 B 4 O 12 :Ce 3+ ,Tb ,Sm , with balanced and preferable comprehensive performances has been developed by energy transfer, suggesting its potential value in the applications of WLEDs.
Abstract: Using in situ DNA polymerase I‐mediated biotin‐dATP nick‐translation (PANT) and terminal deoxynucleotidyl‐transferase‐mediated dUTP nick end‐labeling (TUNEL), we investigated the evolution of strand breaks, a marker damage, rat brain after 1 h middle cerebral artery occlusion various durations reperfusion. single‐strand breaks (SSBs) detected by PANT were present neurons as little min Numbers containing an SSB increased progressively ischemic core but decreased penumbra...
Deactivation of voltage-gated potassium (K+) channels can slow or prevent the recovery from block by charged organic compounds, a phenomenon attributed to trapping compound within inner vestibule closure activation gate. Unbinding and exit channel positively should be favored membrane hyperpolarization if not impeded closed MK-499, methanesulfonanilide compound, is potent blocker (IC50 = 32 nM) HERG K+ channels. This bulky (7 × 20 Å) at physiological pH. Recovery MK-499 other...
Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function cardiomyocytes in vitro. Here we demonstrated a paradigm construct ECTs for cardiac repair using nanomaterials. Single walled (SWNTs) were incorporated into gelatin hydrogel scaffolds three-dimensional ECTs. We found that SWNTs could provide cellular microenvironment vitro favorable contraction expression electrochemical associated proteins. Upon implantation...
The blood-brain barrier (BBB), which is formed by the brain capillary wall, greatly hinders development of new drugs for brain. Over past decades, among various receptor-mediated endogenous BBB transport systems, strategy using transferrin or anti-transferrin receptor antibodies to facilitate drug delivery system particular interest. However, application large proteins still suffers from drawbacks including synthesis procedure, stability, and immunological response. Here, we explored a B6...
Treatment of glioblastoma (GBM) remains to be the most formidable challenge because hindrance blood-brain barrier (BBB) along with poor drug penetration into glioma parenchyma. Nanoparticulate delivery systems (DDS) utilizing transferrin (Tf) as targeting ligand target glioma-associated receptor (TfR) had met problem loss specificity in biological environment due high level endogenous Tf. Here we conjugated CRT peptide, an iron-mimicry moiety whole complex Tf/TfR, poly(ethylene...
Nanocarriers-derived anticancer therapeutics typically suffers from poor tumor penetration and suboptimal antitumor efficacy. Although PEGylation improves the stability of nanoparticles prolongs drug circulation, it further increases size adversely affects penetration. Here, we developed a light-triggered PEGylation/dePEGylation strategy, whereby near-infrared (NIR)-/pH- dual responsive dePEGylation activates iRGD for targeting. The embedded up-conversion (UCNPs) could efficiently convert...
A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) functional peptide-coated gold (GNPs). MSNs are first functionalized acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped positively charged GNPs that decorated oligo-lysine-containing peptide. The resulting hybrid exhibits endo/lysosomal pH triggered release, the incorporation of RGD peptide facilitates targeting αvβ3...
A series of reducible hyperbranched poly(amido amine)s (RHB) with high transfection efficiency were designed and synthesized as nonviral gene delivery vectors. The polycations by Michael addition copolymerization N,N-dimethylaminodipropylenetriamine (DMDPTA) two bisacrylamide monomers N,N′-hexamethylene (HMBA) N,N′-cystamine (CBA). density disulfide linkages in the polymers was tuned varying feed molar ratio monomers. results demonstrate that content RHB controls molecular weight polycation...
A brain drug delivery system for glioma chemotherapy based on transferrin-conjugated biodegradable polymersomes, Tf-PO−DOX, was made and evaluated with doxorubicin (DOX) as a model drug. Biodegradable polymersomes (PO) loaded were prepared by the nanoprecipitation method (PO−DOX) then conjugated transferrin (Tf) to yield Tf-PO−DOX an average diameter of 107 nm surface Tf molecule number per polymersome approximately 35. Compared PO−DOX free DOX, demonstrated strongest cytotoxicity against C6...