A5103979539- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Trace Elements in Health
- Parkinson's Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Neonatal Health and Biochemistry
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Graphene and Nanomaterials Applications
- ATP Synthase and ATPases Research
- Bladder and Urothelial Cancer Treatments
- Retinopathy of Prematurity Studies
- AI in cancer detection
- Sulfur Compounds in Biology
- Abdominal Surgery and Complications
- Mast cells and histamine
- Cancer, Stress, Anesthesia, and Immune Response
- Cellular transport and secretion
- Photodynamic Therapy Research Studies
- Carbon Nanotubes in Composites
- HIV/AIDS drug development and treatment
Wenzhou Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
Tianjin First Center Hospital
2022
Tianjin Medical University
2022
University of Chinese Academy of Sciences
2019-2021
Institute of High Energy Physics
2015-2021
Chinese Academy of Sciences
2013-2021
Centre for Multi-disciplinary Development Research
2017-2021
Chengdu Medical College
2021
In-Q-Tel
2015-2019
Nanocarriers-derived anticancer therapeutics typically suffers from poor tumor penetration and suboptimal antitumor efficacy. Although PEGylation improves the stability of nanoparticles prolongs drug circulation, it further increases size adversely affects penetration. Here, we developed a light-triggered PEGylation/dePEGylation strategy, whereby near-infrared (NIR)-/pH- dual responsive dePEGylation activates iRGD for targeting. The embedded up-conversion (UCNPs) could efficiently convert...
Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature mitochondria, a well-tuned thermoresponsive nanocarrier was developed specifically delivering anticancer drug, paclitaxel (PTX), to mitochondria in cells. The temperature-dependent delivery drugs represents novel strategy.
Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted delivery has been suggested to mitigate cancer. To overcome the intrinsic limitations conventional mitochondrial targeting strategies, we develop temperature-responsive reverse doxorubicin (DOX) lung Results demonstrate that thermoresponsive nanocarrier can prevent DOX efflux and facilitate accumulation DOX-resistant tumors. As consequence, enhances cytotoxicity reverses tumor-bearing mice....
Multidrug resistance (MDR) remains an unmet challenge in chemotherapy. Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(β-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery drug resistant breast cancer MCF-7/ADR cells. DOX-loaded PHP micelles showed rapid cell-internalization and lysosomal escape The cytotoxicity assays relatively higher cell inhibition of than that free DOX...
Abstract Background The introduction of multiparameter MRI and novel biomarkers has greatly improved the prediction clinically significant prostate cancer (csPCa). However, decision-making regarding biopsy prebiopsy examinations is still difficult. We aimed to establish a quick economic tool improve detection csPCa based on routinely performed clinical through an automated machine learning platform (AutoML). Methods This study included multicenter retrospective cohort two prospective cohorts...
Glucose-6-phosphate dehydrogenase (G6PD) has been implicated in the regulation of cellular antioxidative mechanisms. Tumor cells often lose balance oxidation and antioxidation, but role G6PD such an imbalance is still largely unknown. To investigate related function tumor cells, we established a stable line A375 human melanoma with gene knockdown by shRNA lentiviral cloning expression system. The A375-G6PDΔ displayed GFP coexpression after repeated freezethaw cycles multiple passages,...
Highly epitaxial LaBaCo2O5.5+δ (LBCO) thin films were grown on different miscut (001) SrTiO3 substrates (miscut angle of 0.5°, 3.0°, and 5.0°) to study the substrate surface step terrace effect in-plane electrical transport properties. The microstructure studies by X-ray diffraction transmission electron microscopy indicate that as-grown are A-site disordered cubic perovskite structures with c-axis highly oriented along film growth direction. four-probe scanning tunneling (STM) show LBCO...
Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. Here we sought to examine effect chemo-photothermal therapy on an orthotopic mouse model superficial Doxorubicin (DOX) was encapsulated CS/PNIPAAm@SWCNTs nanoparticles. The biodistribution antitumor DOX-loaded nanoparticles were analyzed. accumulated tumor cells upon near-infrared (NIR) irradiation exhibited strong activity mice bearing tumors. In addition,...
Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. However, the application of phototherapy is often compromised by its low efficiency. Herein, we developed novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rPAA@SWCNTs) with photosensitizer, indocyanine green (ICG), for phototherapy. The as-prepared nanoparticles exhibited excellent mitochondria targeting due synergistic properties highly positive charges from polycations...
Herein, we designed near-infrared (NIR)/pH dual-sensitive nanocarriers and evaluated its application to intracellular drug delivery. The were prepared based on amphiphilic poly(β-amino ester) (PBAE) containing o-nitrobenzyl moieties in the backbones upconversion nanoparticles (UCNPs). UCNPs can convert NIR UV that subsequently removes PEG segments from PBAE copolymers, which could enhance protonation of endo/lysosomes facilitate escape lysosomes. In addition, found colocalization with...
Validation of recent findings hot mitochondria in cancer cells is critically needed, since a single fluorescent probe cannot rule out the possibility varied cellular uptake efficiencies. Here we developed ratiometric nanoprobe, named mitochondria-targeted thermoresponsive-gold nanoparticle (MTT-AuNP), for analyzing mitochondrial temperatures. Results confirmed relatively high temperature murine bladder MB49 cells. High temperatures might have far-reaching implications developing therapeutics.
Low cargo-loading capacity and inadequate stability have severely retarded the clinical translation of micellar nanomedicines. Herein, we present a nanosystem prepared by self-assembly doxorubicin (DOX) Fe2+ with drug-metal coordination interactions, followed surface decoration multiarmed PEG-dipyridine. The nanoparticles possessed high drug-loading capability in physiological conditions. Results showed that facilitated intracellular codelivery DOX. Moreover, overload significantly enhanced...
The disulfide bond (SS) has been widely used in prodrugs for the redox-responsive drug release, but its release mechanism and rate were seldom compared different thiol agents. Herein, self-assembling nanoaggregates (NAs) formed by camptothecin (CPT)-oleic acid (OA) linked two frequently SS linkers (ETCSS ACSS) such comparative investigation. It is found that cleavage of ETCSS was directly coupled with CPT whereas breakage ACSS resulted generation intermediates, chemical stability which...
Tumor cells with genetic amplifications or mutations in the fibroblast growth factor receptor (FGFR) family are often addicted to FGFR and heavily dependent on its signaling survive. Although it is critical understand which pathway downstream of plays an essential role guide research development inhibitors, has remained unclear partly because tool compounds used literature also hit many other kinases, making results difficult interpret. With a potent FGFR-specific inhibitor, BGJ398, we now...
Small-molecule ligands for stabilizing the G-quadruplex in telomeres are promising chemotherapeutic agents. Despite extensive research, few G-quadruplex-stabilizing have been clinically approved to date. We hypothesized that metal ions may be able interfere with ligand-mediated stabilization of G-quadruplex. Here we found several could Na(+)-induced conformation even presence a ligand. The destabilizing effects not negligible as most them essential elements organisms. In contrast, Ba(2+) was...
Abstract Environmental factors may play a critical role in the etiology and pathogenesis of Parkinson's disease (PD). However, association PD with specific chemical species remains largely unknown. Here we prepared three kinds iron oxide nanoparticles examined their cytotoxicity cellular model PD. We found that lysosome-targeted showed significant SH-SY5Y cells. Inhibition AMPK could aggravate neurotoxicity as well mitochondrion-targeted nanoparticles. Alteration mitochondrial membrane...