A5016404962- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Crystallization and Solubility Studies
- Surface Modification and Superhydrophobicity
- Medicinal Plant Pharmacodynamics Research
- X-ray Diffraction in Crystallography
- Immune cells in cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer Cells and Metastasis
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Advanced Sensor and Energy Harvesting Materials
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Chemical Synthesis and Reactions
Zhejiang Sci-Tech University
2023-2025
China Pharmaceutical University
2021-2025
Chengdu Medical College
2018-2025
Shenyang Pharmaceutical University
2014-2024
First Affiliated Hospital of Hebei Medical University
2024
ShanghaiTech University
2024
Fujian Medical University
2023
Huazhong Agricultural University
2022
Xiamen Medical College
2022
Eastern Hepatobiliary Surgery Hospital
2016-2021
To compare the survival outcomes of neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy with alone in patients hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT).A randomized, multicenter controlled study was conducted from January 2016 to December 2017 resectable HCC PVTT. Patients were randomly assigned receive RT (n = 82) or 82). The modified Response Evaluation Criteria Solid Tumors (mRECIST) guidelines used evaluate therapeutic effects RT....
Androgen receptor (AR) belongs to the steroid hormone nuclear superfamily. It functions as an androgen-dependent transcriptional factor that regulates genes for cell proliferation and differentiation. Caveolin is a principal component of caveolae membranes serving scaffold protein many signal transduction pathways. Recent results correlate caveolin-1 expression with androgen sensitivity in murine prostate cancer. Furthermore, immunohistochemical staining patient specimens suggests caveolin...
ULK1 is identified as a target in TNBC; thus small-molecule agonist discovered by targeting ULK1-modulated cell death, associated with autophagy and apoptosis.
Background: Achieving a balance between stable drug loading/delivery and on-demand activation/release at the target sites remains significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on design of molecules, offer promising strategy to optimize both delivery efficiency controlled release profiles. Methods: A library doxorubicin (DOX) prodrugs was created by linking DOX fatty alcohols varying chain lengths via tumor-responsive disulfide bond. In vitro...
Poly (ADP-ribose) polymerase-1 (PARP1) is a highly conserved enzyme focused on the self-repair of cellular DNA damage. Until now, numbers PARP inhibitors have been reported and used for breast cancer therapy in recent years, especially TNBC. However, developing new type inhibitor with distinctive skeleton alternatively promising strategy TNBC therapy. In this study, based co-crystallization studies pharmacophore-docking-based virtual screening, we discovered series dihydrodibenzo[b,e]-oxepin...
The inability of many therapeutic molecules to cross the blood-brain barrier (BBB) combined with poor penetration into tumor tissue leads difficult challenges for treatment brain tumors. In order settle these hurdles, we developed a novel multifunctional targeting carrier which enables drugs transport across BBB and targets tissues.In liposomes, natural compound resveratrol (RES) was incorporated lipid bilayer membranes while p-aminophenyl-α-D-manno-pyranoside (MAN) wheat germ agglutinin...
The aim of this study was to explore the autophagy-related protein 4B(ATG4B) and its targeted candidate agonist in triple-negative breast cancer (TNBC) therapy.
Vascular invasion, including microvascular invasion (MVI) and portal vein tumor thrombus (PVTT), is associated with the postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to investigate potential impact hepatitis B virus (HBV) activity on development vascular invasion. Patients HBV tumor-related factors HCC who had undergone hepatectomy were retrospectively enrolled analyzed identify risk for developing A total 486 patients included in this study. The overall proportion MVI...
Abstract Cancerous cells exhibit overexpression of multiple enzymes in various cellular compartments. These are often undruggable, yet display unique advantages regulating intracellular self‐assembly and dis‐assembly small molecules for cancer targeting. Herein, a self‐assembling molecule (LND‐1p‐ES) carrier‐free delivery lonidamine specifically to cancerous is designed, where LND‐1p‐ES executes as both drug carrier with combined benefits thereof. Under the precise regulation phosphatase...
Abstract Photodynamic therapy (PDT) is an effective approach for treating melanoma. However, the photosensitizers employed in PDT can accumulate healthy tissues, potentially causing harm to normal cells and resulting side effects such as heightened photosensitivity. To address this, activatable photosensitizer (PSD) by linking PpIX with a fluorescence quencher using disulfide bond designed. PSD responded endogenous GSH, showing high selectivity A375 cells. enhance PSD's bioavailability...
Abstract α‐Olefins are valued and abundant building blocks from fossil resources. They widely used to provide small‐molecule or polymeric products. Despite numerous advantages of radical polymerization, it has been well‐documented as textbook knowledge that α‐olefins their functionalized derivatives cannot be radically homopolymerized because the degradative chain transfer side reactions. Herein, we report our studies on homopolymerization thiocyanate enabled by 1,4‐cyano group migration...
Abstract BACKGROUND The advent of the prostate‐specific antigen (PSA) test has had a profound impact on diagnosis and treatment prostate carcinoma. However, use PSA levels alone for screening carcinoma was compromised by variations in amount produced benign prostatic tissue specimens. Proteins were involved various pathways that determine behavior cell. Therefore, information regarding proteins may reveal drug targets and/or markers early detection. METHODS authors used surface‐enhanced...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Although much known about both cellular changes that lead to HCC and etiological agents responsible for majority cases, molecule pathogenesis still not well understood. We aimed determine effect c-Myc gene expression on proliferative, invasive, migrative capabilities hepatocellular HepG2 cells.A plasmid- based polymerase III promoter system was used deliver express short interfering RNA targeting reduce its in cells....
In the present study, we investigated role of lipid composition camptothecin (CPT)-loaded liposomes (CPT-Lips) to adjust their residence time, drug distribution, and therefore toxicities antitumor activity. The CPT was loaded into using a click loading method, which utilized preloaded with GSH then exposed CPT-maleimide. method produced CPT-Lips high encapsulation efficiency (>95%) sustained release. It is shown that times in body were highly dependent on compositions an order non-PEGylated...
Various industries generate a large amount of wastewater, which contains soluble organic compounds that can seriously jeopardize the environment and human health. Therefore, new photocatalytic materials with function efficiently degrading pollutants have become research hotspot. In this research, bimetallic metal-organic frameworks (MOFs) core-satellite structure were prepared through simple one-pot method in presence polyvinylpyrrolidone structure-directing agent crystal size. Also, synergy...
Noninvasive monitoring of chymotrypsin-like (ChT-L) activity proteasomes is great significance for the diagnosis and prognosis various cancers. However, commercially available proteasome probes usually lack adequate cancer-cell selectivity. To noninvasively monitor ChT-L in living cells, we rationally designed a cascade-activated AIEgen-peptide probe (abbreviated as TPE-1p), which self-assembled aqueous solution to exhibit bright fluorescence response sequential treatment alkaline...