A5100636824- Click Chemistry and Applications
- Carbon dioxide utilization in catalysis
- Biotin and Related Studies
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Nutritional Studies and Diet
- RNA Interference and Gene Delivery
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Chemistry and Chemical Engineering
- Catalytic C–H Functionalization Methods
- Vanadium and Halogenation Chemistry
- Diet and metabolism studies
- Peer-to-Peer Network Technologies
- biodegradable polymer synthesis and properties
- Caching and Content Delivery
- Sodium Intake and Health
- Genomics and Phylogenetic Studies
- Advanced Photocatalysis Techniques
- Asymmetric Hydrogenation and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Radiopharmaceutical Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
Peking University
2017-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Center for Life Sciences
2024-2025
Chinese Academy of Sciences
2025
Macau University of Science and Technology
2025
Lanzhou University
2025
Beijing National Laboratory for Molecular Sciences
2021-2024
Nanjing Tech University
2023-2024
Liaocheng University
2024
Jilin Agricultural University
2024
Abstract Vanadium mining activities can cause contamination of the surrounding geological environment. may exist in multiple matrices due to its migration and transformation, forming interactive relationships; however, connection between vanadium distributions microbial community responses remains largely unknown. is a redox‐sensitive metal that be microbiologically reduced immobilized. To date, bioremediation vanadium‐contaminated environments by indigenous microorganisms has rarely been...
Abstract In situ profiling of subcellular proteomics in primary living systems, such as native tissues or clinic samples, is crucial for understanding life processes and diseases, yet challenging due to methodological obstacles. Here we report CAT-S, a bioorthogonal photocatalytic chemistry-enabled proximity labeling method, that expands wide range samples mitochondrial proteomes. Powered by our thioQM warhead development targeted chemistry, CAT-S enables the proteins cells with high...
Spatiotemporally resolved dissection of subcellular proteome is crucial to our understanding cellular functions in health and disease. We herein report a bioorthogonal photocatalytic decaging-enabled proximity labeling strategy (CAT-Prox) for spatiotemporally mitochondrial profiling living cells. Our systematic survey the photocatalysts has led identification Ir(ppy)2bpy as mitochondria-targeting catalyst that allowed photocontrolled, rapid rescue azidobenzyl-caged quinone methide highly...
Abstract Utilization of electro‐responsive biomaterials with antibacterial properties is advantageous for facilitating septic wound healing and tissue regeneration. However, the dose‐response effects electrical stimuli from these materials against bacteria are not rigorously characterized, achieving synergy bactericidal pro‐regenerative remains a major challenge. Here, graded series flexible BaTiO 3 /P(VDF‐TrFE) electroactive nanocomposite membranes (EMs) developed varying surface charge...
A series of 2-arylbenzothiazoles and their derivatives were prepared in high yields by visible light-induced intramolecular cyclization under mild conditions using TAPT-TP-COF as a photocatalyst.
The soluble dietary fiber (SDF) was made from separate and co-fermented okara utilizing Lactic acid bacteria (LAB) Kluyveromyces marxianus C21, the physicochemical functional properties of SDF were assessed both before after modification. results showed that compared with non-fermented okara, content LAB K. C21 increased by 16.9%, 19.5%, 21.6%, respectively. Scanning electron microscopy studies to had most excellent porous surface, loosest structure, a greater specific surface area. ratios...
Effective antitumor immunity hinges on the specific engagement between tumor and cytotoxic immune cells, especially T cells. Although investigating these intercellular interactions is crucial for characterizing responses guiding immunotherapeutic applications, direct quantitative detection of tumor–T cell within a live-cell context remains challenging. We herein report photocatalytic interaction labeling strategy (CAT-Cell) relying bioorthogonal decaging quinone methide moieties sensitive...
Few studies have evaluated the intake trends of fatty acids in China. The present study aimed to describe profile longitudinal dietary fat and acid intakes their related food sources Chinese adults.A using data from China Health Nutrition Survey (1997-2011) was conducted. Dietary estimated 24 h recalls combined with a inventory for three consecutive days. Linear mixed models were used calculate adjusted mean values.Urban rural communities nine provinces (autonomous regions), China.Adults (n...
Abstract Cancerous cells exhibit overexpression of multiple enzymes in various cellular compartments. These are often undruggable, yet display unique advantages regulating intracellular self‐assembly and dis‐assembly small molecules for cancer targeting. Herein, a self‐assembling molecule (LND‐1p‐ES) carrier‐free delivery lonidamine specifically to cancerous is designed, where LND‐1p‐ES executes as both drug carrier with combined benefits thereof. Under the precise regulation phosphatase...
Abstract The development of visual and multifunctional sensors, further the fabrication portable sensing devices is great importance. Herein, two dinuclear lanthanide clusters are designed, their accurate molecules determined to be [Ln 2 (DFBA) 6 (dmp) (H O) ] (Ln 3+ = Eu ( 1‐Eu ) or Tb 1‐Tb ), HDFBA 3,4‐difluorobenzoic acid, dmp 4,7‐dimethyl‐1,10‐phenanthroline), by single‐crystal X‐ray diffraction. Interestingly, shows rapid detection ferrous ions (Fe 2+ acetylacetone (acac), with limit...
γ-Aminobutyric acid (GABA) has been shown to have many beneficial functions and received widespread attention. To broaden the application of GABA-rich fermentation supernatant, this study investigated lipid-lowering capacity supernatant from fermented okara (FOS-G) in vitro. The results showed that FOS-G improved oxidative stress OA-induced HepG2 cells by reducing content reactive oxygen species (ROS) malondialdehyde (MDA). Furthermore, lipid accumulation total cholesterol (TC) triglyceride...
A phosphine-catalyzed tandem cyclization reaction has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives, which contain three consecutive asymmetric centers. The good yield, excellent stereoselectivity, and Z/E selectivity. new method is simple, requires only mild conditions, shows tolerance for various functional groups. Similarly, this can be catalyzed by chiral phosphine catalyst achieve synthesis.
Zwitterionic catalytic model for ring-opening polymerization (ROP) was unveiled. Among the designed quaternary ammonium carboxylate zwitterionic catalysts, carnitine, a natural product zwitterion, showed optimal performance in ROPs of cyclic esters.
This study aimed to investigate the effects of different defatting methods black soldier fly (Hermetia illucens) larvae meal (BSFM) on metabolic energy and nutrient digestibility in laying hens. Sixty young hens (Hy-Line W-36) aged 63 days were randomly divided into two groups (G1 G2), each with five replicates six housed individual cages. Group G1 was fed 25% pressed (BSFMp) 75% basal diet, G2 extracted (BSFMe) a diet. Both diets included 5 g/kg chromium oxide as an external marker. A 7-day...
Abstract Herein, the development of a visible‐light‐induced catalytic system to achieve decarboxylative acylation pyridine N ‐oxides with α‐oxocarboxylic acids, at room temperature and using organic dye fluorescein dimethylammonium as new type photocatalyst, is reported. A series 2‐arylacylpyridine were selectively synthesized in moderate good yields by controlling polarity reaction solvent. The developed strategy was successfully applied synthesis an important intermediate drug,...
Biophysical cues play a crucial role in T cell biology, yet their implications adoptive therapy (ACT) remain largely unknown. Here, we investigate the effect of electrical stimuli on CD8+ cells using charged substrate composed electroactive nanocomposites with tunable surface charge intensities. Electrical enhance persistence and tumor-suppressive efficacy transferred cells, effects dependent charge. Single-cell RNA-sequencing analysis unveils decrease virtual memory (Tvm) an increase...
Obesity has emerged as a global health issue with its prevalence continuously increasing and being associated multiple comorbidities. Although existing medications are effective, they often come significant side effects, making dietary therapy an advantageous alternative. Hawthorn leaves their active component, vitexin, have shown potential in regulating lipid metabolism improving gut microbiota imbalance. This study utilized high-fat diet-induced obese mouse model, administering different...
Rationale: Effective delivery of small interfering RNA (siRNA) remains a significant challenge in treating hypercholesterolemia due to biocompatibility, cellular uptake, and endosomal escape issues. Rational regulation carrier surface charge contributes efficient siRNA vivo. Methods: This study introduces zwitterionic lipid nanoparticles (ZwiLNPs) as novel solution these challenges. By leveraging the unique properties polymers, we achieved robust encapsulation targeted delivery. The design...