A5115594217- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Karst Systems and Hydrogeology
- Pulmonary Hypertension Research and Treatments
- Biomarkers in Disease Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Pain Mechanisms and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- GDF15 and Related Biomarkers
Peking University
2021-2025
State Power Investment Corporation (China)
2025
Beijing Sport University
2024
Union Hospital
2015-2024
Jilin University
2015-2024
Nantong University
2024
Westlake University
2024
Huazhong University of Science and Technology
2024
Wuhan Union Hospital
2024
Nanjing Drum Tower Hospital
2024
To assess the frequency of cardiovascular and venous thromboembolic events in clinical studies baricitinib, an oral, selective JAK1 JAK2 inhibitor approved more than 50 countries for treatment moderately-to-severely active rheumatoid arthritis (RA).Data were pooled from 9 RA studies. Placebo comparison up to 24 weeks included data 6 Randomized dose between baricitinib doses 2 mg 4 used associated long-term extension study. The analysis set designated "All-bari-RA" all exposures at any...
Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of oral Janus kinase (JAK)1/JAK2 inhibitor, baricitinib, in 18 patients with Mendelian interferonopathies who are enrolled a compassionate use program. Patients received doses between 0.1 17 mg per day. Covariates weight and renal function significantly influenced volume-of-distribution clearance, respectively. The half-life baricitinib less than 40 kg substantially shorter adult populations, requiring need...
Background Systemic lupus erythematosus (SLE) is a multi-organ chronic autoimmune disease. Inflammatory bowel disease (IBD) common inflammatory of the gastrointestinal tract. Previous studies have shown that SLE and IBD share pathogenic pathways genetic susceptibility, but specific mechanisms remain unclear. Methods The datasets were downloaded from Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) identified using Limma package. Weighted gene coexpression network analysis...
B cell-activating factor of the tumor necrosis family (BAFF/BLys) plays a critical role in cell survival and immune responses through its three receptors: BAFF receptor (BAFF-R/BR3), transmembrane activator calcium modulator cyclophilin ligand interactor (TACI) maturation antigen (BCMA). Using specific antibodies, we have investigated expression BAFF-R on human tonsillar cells their functional roles naive germinal center (GC) differentiation. Our studies show that is dominant cells. However,...
Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors. Patients with mutations HOIL1 (RBCK1) present amylopectinosis-associated myopathy without hyper-inflammation and immunodeficiency. We report that barrier-raised HOIL-1-deficient mice exhibit amylopectin-like deposits myocardium but show minimal signs hyper-inflammation. However, they immunodeficiency upon acute infection Listeria monocytogenes, Toxoplasma gondii Citrobacter...
This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, demonstrated remarkable capabilities, often achieving human-level or superior in areas ranging from coding challenges to scientific processing creative problem-solving. Key findings include: -83.3%...
Abstract Objective Osteopontin (OPN) that is aberrantly produced in rheumatoid synovium thought to play an important role arthritis (RA). This study was undertaken investigate the of OPN differentiation and accumulation Th17 cells synovium. Methods Peripheral blood mononuclear purified CD4+ T derived from patients with RA or healthy controls were used test effect vitro. Cytokine expression determined by enzyme‐linked immunosorbent assay quantitative polymerase chain reaction. Intracellular...
Cardiac fibrosis is a biological process that increases with age and contributes to myocardial dysfunction. Humanin (HN) an endogenous mitochondria-derived peptide has cytoprotective effects reduces oxidative stress. The present study aimed test the hypothesis chronic supplementation of exogenous HN in middle-aged mice could prevent reverse cardiac apoptosis aging heart. Female C57BL/6N at 18 mo received 14-mo intraperitoneal injections vehicle (old group; n = 6) or analog (HNG; 4 mg/kg 2...
Coating superparamagnetic iron oxide (SPIO) with dextran increases the stability of magnetic nanoparticles during blood circulation, yet this is accompanied by an increase in particle size and vascular permeability efficiency SPIO into joints decreases. In our study, thickness coated onto (dex-SPIO) was optimized without affecting quality adding a suitable amount glucose crystal growth process. To further improve signal enhancement effect (glu-dex-SPIO) for detection inflammatory site...
Abstract Ankylosing spondylitis (AS) is a chronic axial spondyloarthritis (SpA) resulting in back pain and progressive spinal ankyloses. Currently, there are no effective therapeutics targeting AS largely due to elusive pathogenesis mechanisms, even as potential candidates such HLA-B27 autoantigen have been identified. Herein, we employed proteoglycan (PG)-induced mouse model together with clinical specimens, found that the complement system was substantially activated bone marrow,...
The initial interaction between B cells and follicular dendritic (FDCs) appears to be essential for germinal center (GC) formation. To identify molecules regulating this interaction, we generated FDC-staining monoclonal antibodies (mAbs) screened them their ability block FDC-mediated costimulation of growth differentiation CD40-stimulated cells. Using one the inhibitory mAbs, 8D6, expression cloned cDNA encoding 8D6 antigen (Ag) from a human FDC line, HK. Ag is novel protein 282 amino acids...
Introduction Despite proven benefits, patients with coronary heart disease (CHD) typically fail to participate in sufficient physical activity (PA). Effective interventions should be implemented help maintain a healthy lifestyle and modify their present behavior. Gamification is the use of game design features (such as points, leaderboards, progress bars) improve motivation engagement. It shows potential for encouraging engage PA. However, empirical evidence on efficacy such among CHD still...
Synopsis for table of contents An exceptional number synchronous MTC/PTC in the same thyroid gland is presented. This may be most numerous case series reported literature. Synchronous PTC/MTC were classified into 4 subtypes and clinical pathological aspects as well results are Background objectives The occurrence multiple neoplastic processes unusual. We investigated clinicopathological features 30 medullary carcinomas (MTC) association with papillary (PTC). Method Retrospective analysis...
Abstract Innate immunity has recently gained renewed interest in its ability to regulate adaptive immunity. Among the innate immune signals, CpG DNA revealed potential as a vaccine adjuvant. However, cellular mechanism for effect of on humoral response is not well understood. Here, we investigated effects human B cell differentiation using highly purified subsets: naive, germinal center (GC), and memory cells. In vitro culture system that mimics primary or secondary vivo, markedly augmented...
Biophysical cues play a crucial role in T cell biology, yet their implications adoptive therapy (ACT) remain largely unknown. Here, we investigate the effect of electrical stimuli on CD8+ cells using charged substrate composed electroactive nanocomposites with tunable surface charge intensities. Electrical enhance persistence and tumor-suppressive efficacy transferred cells, effects dependent charge. Single-cell RNA-sequencing analysis unveils decrease virtual memory (Tvm) an increase...
<title>Abstract</title> <italic><bold>Background:</bold></italic><bold> </bold>Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin subtype in adult patients, with an annual incidence rate ranging from 25.0% to 40.0% worldwide. Nevertheless, prognosis forthe disease remains poor. <italic><bold>Objective:</bold></italic> There a pressing need for new, reliable biomarkers prediction. <italic><bold>Methods: </bold></italic>Using 449 DLBCL samples Gene Expression Omnibus dataset,...
Torrefaction is a promising pretreatment method to enhance the physical and chemical properties of corn straw for bioenergy applications. In this study, torrefaction experiments were conducted in continuous screw reactor under varying temperatures feed rates. The quality resulting biochar was assessed using color difference analysis, with defined threshold determine product qualification (i.e., compliance rate). Results showed that rate dropped from 78% 61% as increased 0.5 kg/h 1.5 kg/h. To...