A5003582426- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiac Health and Mental Health
- Berberine and alkaloids research
- Plant Gene Expression Analysis
- Mobile Health and mHealth Applications
- RNA Research and Splicing
- Physical Activity and Health
- Pulmonary Hypertension Research and Treatments
- Alkaloids: synthesis and pharmacology
- Mechanical Circulatory Support Devices
- Pancreatic and Hepatic Oncology Research
- Vascular anomalies and interventions
- RNA modifications and cancer
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Risk Factors
- Congenital Heart Disease Studies
- Nuclear Receptors and Signaling
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
National Institutes for Food and Drug Control
2025
China Banking Regulatory Commission
2025
Xuzhou Children Hospital
2024
First Bethune Hospital of Jilin University
2022-2024
University of Chinese Academy of Sciences
2020-2024
Zhejiang Hospital
2018-2024
Weatherford College
2024
Huazhong Agricultural University
2012-2024
Herein, we define the role of ferroptosis in pathogenesis diabetic cardiomyopathy (DCM) by examining expression key regulators mice with DCM and a new ex vivo model. Advanced glycation end-products (AGEs), an important pathogenic factor DCM, were found to induce engineered cardiac tissues (ECTs), as reflected through increased levels Ptgs2 lipid peroxides decreased ferritin SLC7A11 levels. Typical morphological changes cardiomyocytes observed using transmission electron microscopy....
Abstract The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is rate-limiting enzyme that hydroxylates and generates levodopa ( l -dopa) with tetrahydrobiopterin (BH 4 ) as a coenzyme. Here, we show oral berberine (BBR) might supply H • through dihydroberberine (reduced BBR produced by bacterial nitroreductase) promote production of BH from dihydrobiopterin; increased enhances TH activity, which accelerates -dopa gut...
Abstract Trimethylamine- N -oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in and treat atherosclerosis. Effects of BBR on microbiota, as well plaque development atherosclerosis were investigated culture animal intestinal bacterial, HFD-fed animals atherosclerotic patients, respectively. We found that oral lowers biosynthesis intestine through interacting with enzyme/co-enzyme...
Nitroreductases (NRs) are bacterial enzymes that reduce nitro-containing compounds.We have previously reported NR of intestinal bacteria is a key factor promoting berberine (BBR) absorption.We show here feeding hamsters with high fat diet (HFD) caused an increase in blood lipids and activity the intestine.The elevation fecal by HFD was due to either fraction NR-producing or their intestine.When given orally, BBR bioavailability HFD-fed higher than those fed normal chow (by +72%, *P<0.05).BBR...
Inhibition of total histone deacetylases (HDACs) was phenomenally associated with the prevention diabetic cardiomyopathy (DCM). However, which specific HDAC plays key role in DCM remains unclear. The present study designed to determine whether can be prevented by inhibition HDAC3 and elucidate mechanisms prevents DCM. Type 1 diabetes OVE26 age-matched wild-type (WT) mice were given selective inhibitor RGFP966 or vehicle for 3 months. These then killed immediately months later cardiac...
The treatment of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation remains challenging in current clinical practice.
Long noncoding RNAs (lncRNAs) play important roles in the spatial and temporal regulation of muscle development regeneration. Nevertheless, determination their biological functions mechanisms underlying regeneration remains challenging. Here, we identified a lncRNA named lncMREF (lncRNA enhancement factor) as conserved positive regulator among mice, pigs humans. Functional studies demonstrated that lncMREF, which is mainly expressed differentiated satellite cells, promotes myogenic...
Diabetic cardiomyopathy (DCM) is highly prevalent in type 2 diabetes (T2DM) patients. Zinc an important essential trace metal, whose deficiency associated with various chronic ailments, including vascular diseases. We assessed T2DM B6.BKS(D)-Leprdb/J (db/db) mice fed for six months on a normal diet containing three zinc levels (deficient, adequate, and supplemented), to explore the role of DCM development progression. Cardiac function, reflected by ejection fraction, was significantly...
The present study aimed to determine the mediating effects of depression and anxiety on association between life satisfaction quality life. We used Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), EuroQol Five Dimensions (EQ-5D) measure depression, anxiety, life, respectively. A single question was participants. Life significantly related with ( r = −0.17), −0.18), 0.19). Depression were also had full (β −0.274; β −0.208) For those poor satisfaction, people...
Late embryogenesis abundant (LEA) proteins comprise a large family that plays important roles in the regulation of abiotic stress, however, no in-depth analysis LEA genes has been performed grapevine to date. In this study, we analyzed total 52 putative at genomic and transcriptomic level, compiled expression profiles four selected (V. amurensis) VamLEA under cold osmotic stresses, studied potential function V. amurensis DEHYDRIN3 (VamDHN3) gene callus. The were classified into seven...
Abstract Hypertension is a global health issue, and reduced exercise capacity unavoidable for older people. According to recent clinical studies, the intestinal microbiota play crucial role in pathogenesis of many human diseases. We investigated whether specific alterations gut contribute elderly patients with hypertension. This study enrolled 56 subjects, all performed cardiopulmonary test underwent fecal bacteria sequencing (16 s ribosomal RNA V4 region). peak oxygen uptake values, were...
Introduction Despite proven benefits, patients with coronary heart disease (CHD) typically fail to participate in sufficient physical activity (PA). Effective interventions should be implemented help maintain a healthy lifestyle and modify their present behavior. Gamification is the use of game design features (such as points, leaderboards, progress bars) improve motivation engagement. It shows potential for encouraging engage PA. However, empirical evidence on efficacy such among CHD still...
Helicobacter pylori (H ) infection was common worldwide and previous researches on the correlation between H metabolic abnormality provided inconsistent conclusions. We assessed acute prevalence relationship with in general Chinese population. Participants attending for physical examination underwent a carbon-13 urea breath test. For individual, following data were collected: age, gender, body mass index (BMI), systolic blood pressure, diastolic total protein, albumin, globulin (GLB),...