A5052604578- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- MicroRNA in disease regulation
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Telomeres, Telomerase, and Senescence
- Occupational exposure and asthma
- Vitamin D Research Studies
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Gout, Hyperuricemia, Uric Acid
- Diabetes and associated disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Fibrosis and Remodeling
- Congenital Heart Disease Studies
- Topic Modeling
- Endoplasmic Reticulum Stress and Disease
- Advanced Algorithms and Applications
- Chronic Myeloid Leukemia Treatments
- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
First Hospital of Jilin University
2018-2025
Jilin University
2018-2025
Third Xiangya Hospital
2025
Central South University
2025
East China Normal University
2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Southeast University
2010-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
BACKGROUND Autoimmune hemolytic anemia (AIHA) is a characterized by autoantibodies against red blood cells. Patients with AIHA can have 4 subtypes of IgG-type cell antibodies: IgG1, IgG2, IgG3, and IgG4. The development this disease closely related to IgG 1 3, the combination high IgG4 rare. A patient autoimmune who had poor response steroid combined immunosuppressive regimen (methylprednisolone cyclophosphamide) received sessions protein immunosorbent therapy good results still under...
Quercetin exerts anti-inflammatory, anti-oxidant and other protective effects. Previous studies have shown that senescent cells, such as fibroblasts type II airway epithelial are strongly implicated in the development of pulmonary fibrosis pathology. However, role macrophages during silicosis remains unclear. We investigated effects quercetin on macrophage senescence fibrosis, explored underlying mechanisms. Mice were randomized to six model groups. Vitro was also established by culturing...
Bilobalide, a unique Ginkgo biloba constituent has attracted significant interest as novel therapeutic option for neuronal protection. However, there is paucity of data on its effect colitis. This work sought to evaluate the bilobalide macrophage polarization in vitro and dextran sulfate sodium (DSS) induced colitis vivo. Through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) annexin V/PI assay, it was shown that no toxicity macrophage. Lipopolysaccharide (LPS)...
Panax ginseng C. A. Meyer (Araliaceae) is a famous Asian medicine. Ginsenoside Rc component isolated from ginseng.This study evaluates the effect of ginsenoside on myocardial ischaemic injury.Male Swiss mice were subcutaneously injected with 50 mg/kg isoproterenol once day for three days. (10, 20, or 40 mg/kg) was intragastrically administered 1 h after injection. The in control group normal saline and given 0.5% CMC-Na. CK-MB troponin T assayed. Histopathological examination myocardium...
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, specific mechanism glycolysis silicosis still not clear. In this study, silicotic models and silica-induced macrophage were used to elucidate induced by silica. Expression levels key enzymes activation indicators analyzed Western blot, qRT-PCR, IHC, IF analyses, using a lactate assay kit. We found that silica promotes expression HK2, PKM2, LDHA, factors iNOS, TNF-α, Arg-1, IL-10,...
Early growth response 1 (EGR1) is a crucial transcription factor composed of zinc finger structures, inhibitory and activating regulatory regions. We identified the biological effect molecular mechanisms EGR1 in breast cancer (BC).
New-onset atrial fibrillation (NOAF) is associated with increased morbidity and mortality. Despite identifying numerous factors contributing to NOAF, the underlying mechanisms remain uncertain. This study introduces triglyceride-glucose index (TyG index) as a predictive indicator establishes clinical model. We included 551 patients acute myocardial infarction (AMI) without history of (AF). These were divided into two groups based on occurrence postoperative NOAF during hospitalization: group...
Social media has rapidly intervened in the interaction between urban consumers and commercial space, further reshaping structure of space. This study employed social, spatial, subjective dimensions geographies consumption as theoretical framework. Based on data from five social platforms, including Douyin, REDnote, Weibo, Dianping, Baidu Index, we constructed a multi-level evaluation method “attention level–activity degree–experience quality” applied it to measure dynamics shopping malls...
Intranasal drug delivery via nanocarriers has long been a research focus for enhancing concentration in the brain. However, strategy of exploiting blood-brain barrier (BBB) alterations atherosclerotic mouse models to enhance nanoparticle-mediated bromocriptine hypothalamus treatment prolactinomas with hyperprolactinemia not yet reported. This study reveals that patients complicated by arteriosclerosis, therapy more effectively attenuates postoperative elevations prolactin levels. In model,...
Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung macrophages bone osteoclasts after silica inhalation in rats.Wistar rats NR8383 RAW 264.7 cell lines were used study. receptor activator nuclear factor kappa-B ligand (RANKL) toll-like 4 (TLR4) signaling pathways measured tissue or NR8383/RAW cells exposed...
Glycolysis and ER stress have been considered important drivers of pulmonary fibrosis. However, it is not clear whether glycolysis are interconnected if those interconnections regulate the development Our previous studies found that expression LDHA, a key enzyme involved in glycolysis, was increased silica-induced macrophages silicotic models, closely related to silicosis fibrosis by participating inflammatory response. pharmacological inhibition LDHA beneficial amelioration remains unclear....
Abstract Background Interleukin 1 beta (IL-1β) contributes to the development of inflammatory bowel disease (IBD) and is correlated with severity intestinal inflammation. However, precise source IL-1β producing cells in DSS colitis currently not known. Methods To determine activity during inflammation real time, an transgenic mouse has been generated by incorporating firefly luciferase gene driven a 4.5-kb fragment human promoter (named cHS4I-hIL-1βP-Luc mice). Dextran sodium sulfate (DSS)...
Abstract Background There are only a few studies on sex hormones in females of different ages suffering from depression, and their conclusions not uniform until now. This study aimed to investigate the correlation between severity depression factors such as differences hormone levels ages, exploring variations after treatment. Methods A total 169 with were selected divided into first-episode (91 cases) recurrent (78 groups. Then, basis age, patients young (48 cases, age < 45 years),...
The role and mechanisms of integrated stress response inhibitor (ISRIB) on silicosis are still not well defined. In the present study, effects ISRIB cellular senescence pulmonary fibrosis in were evaluated by RNA sequencing, micro-computed tomography, function assessment, histological examination, Western blot analysis. results showed that significantly reduced degree mice with expression type I collagen, fibronectin, α-smooth muscle actin, transforming growth factor-β1. Both vivo vitro...
Silicosis is the most prevalent occupational disease in China. It a form of pulmonary fibrosis caused by inhalation silicon particles. As there no cure for potentially lethal and progressive condition, treatment silicotic an important difficult problem to address. Thalidomide, drug with anti-inflammatory immunoregulatory properties, has been reported have lung-protective effects. The purpose this study was observe therapeutic effect thalidomide on mice determine protective mechanism. By...
Cellular senescence has been considered an important driver of many chronic lung diseases. However, the specific mechanism cellular in silicosis is still unknown. In present study, silicotic rats and osteoclast stimulatory transmembrane protein ( Ocstamp ) overexpression MLE‐12 cells were used to explore OC‐STAMP alveolar epithelial cell type II (AEC2). We found increasing level AEC2 rats. Overexpression promoted epithelial‐mesenchymal transition (EMT), endoplasmic reticulum (ER) stress,...
Mechanisms of silicosis have yet to be clarified, and pathological conditions are inaccurately described in some experimental studies on silicosis. This study was aimed at describing initial lesions silicosis, as observed rats with silica exposure via inhalation, major histopathologic alterations. Male Wistar were exposed for 24 weeks. Hematoxylin eosin staining indicated the presence "cellular nodule+ macrophage alveolitis" from 2-16 weeks time points "fibrotic cellular + nodule" inhalation...
Mechanisms of silicosis, caused by the inhalation silica are still unclear, and effect sex on silicosis has rarely been reported. The purpose this study was to investigate whether affects silicotic lesions progressive fibrotic responses in silicosis. Our showed that had no significant area silicon nodules collagen deposition after a one-time bronchial perfusion silica. Immunohistochemical staining CD68 transforming growth factor-β1 (TGF-β1) were positive male female mice. In addition,...