A5103168490- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Muscle Physiology and Disorders
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
- Animal Genetics and Reproduction
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- COVID-19 diagnosis using AI
- Inflammation biomarkers and pathways
- Advanced biosensing and bioanalysis techniques
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Clinical Nutrition and Gastroenterology
- Barrier Structure and Function Studies
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Plant and Fungal Interactions Research
Northwest A&F University
2022-2025
Ministry of Agriculture and Rural Affairs
2018-2024
Huazhong Agricultural University
2016-2024
First Affiliated Hospital of Zhengzhou University
2020-2022
First Affiliated Hospital of Henan University of Science and Technology
2018
IFOM
2017
European Institute of Oncology
2017
ETH Zurich
2017
University of Milan
2017
Uppsala University
2017
Significance While numerous long noncoding RNAs (lncRNAs) have been identified in muscle, most of their roles myogenesis remain unclear, and many more lncRNAs yet to be identified. In this study, we an intronic lncRNA, SYISL ( SYNPO2 intron sense-overlapping lncRNA), which is highly expressed muscle interacts directly with polycomb repressive complex 2 (PRC2) repress development. The results reveal that acts as a regulatory RNA PRC2-mediated myogenesis.
Neat1 is widely expressed in many tissues and cells exerts pro-proliferation effects on cancer cells. However, little known about the function of myogenesis. Here we characterized roles muscle cell formation regeneration. Gain- or loss-of-function studies C2C12 demonstrated that accelerates myoblast proliferation but suppresses differentiation fusion. Further, knockdown vivo increased cross-sectional area fibers impaired Mechanically, physically interacted with Ezh2 mainly through core...
The mechanistic foundation of vascular maturation is still largely unknown. Several human pathologies are characterized by deregulated angiogenesis and unstable blood vessels. Solid tumors, for instance, get their nourishment from newly formed structurally abnormal vessels which present wide irregular interendothelial junctions. Expression clustering the main endothelial-specific adherens junction protein, VEC (vascular endothelial cadherin), upregulate genes with key roles in...
Abstract Background Long non‐coding RNAs (lncRNAs) play critical regulatory roles in diverse biological processes and diseases. While a large number of lncRNAs have been identified skeletal muscles until now, their function underlying mechanisms myogenesis remain largely unclear. Methods We characterized novel functional lncRNA designated lncMGPF (lncRNA muscle growth promoting factor) using RACE, Northern blot, fluorescence situ hybridization quantitative real‐time PCR. Its was determined...
Eicosapentaenoic acid regulates glucose uptake in skeletal muscle and significantly affects whole-body energy metabolism. However, the underlying molecular mechanism remains unclear. Here we report that eicosapentaenoic activates phosphoglycerate mutase 2, which mediates conversion of 2-phosphoglycerate into 3-phosphoglycerate. This enzyme plays a pivotal role glycerol degradation, thereby facilitating proliferation differentiation satellite cells muscle. Interestingly, 2 inhibits...
Skeletal muscle is the major tissue for metabolic activity in body and performs a variety of physiological functions. Among these, fiber types are decisive function meat quality. Numerous studies have shown that natural products can affect development skeletal muscle, regulate formation fibers, impact under or pathological conditions. Baicalin, flavonoid compound mainly derived from dried roots Scutellaria baicalensis, has been reported to glucose metabolism insulin resistance muscle....
Abstract Background and Aim: The high expression of the galectin‐1 predicts poor patient outcome in several tumors. aim this study was to investigate its prognostic value patients with hepatocellular carcinoma (HCC) after resection. Methods: Galectin‐1 tumor‐infiltrating FoxP3 + regulatory T cells (Tregs) were validated by tissue microarrays from HCC ( n = 386) statistically assessed for correlations clinical profiles prognosis patients. Results: We found that galectin‐1, which prevalently...
Abstract Background Skeletal muscle is composed of fibers with different physiological characteristics, which plays an important role in regulating skeletal metabolism, movement and body homeostasis. The type fiber directly affects meat quality. However, the transcriptome gene interactions between types are not well understood. Results In this paper, we selected 180-days-old Large White pigs found that longissimus dorsi (LD) was dominated by fast-fermenting myofibrils soleus (SOL)...
Pigs are vital for meat production, and their intramuscular fat content significantly impacts pork quality flavor. Using single-cell RNA sequencing (scRNA-seq) on porcine fat, we found that adipose progenitor cells express highly inflammatory genes, including IL-1α, during adipogenic differentiation. a pro-inflammatory cytokine present in various cell types, can translocate to the nucleus via its nuclear localization sequence (NLS), yet function remains unclear. By constructing an...
Abstract Background and Aim Regulatory T cells ( reg) play a vital role in immunosuppressive crosstalk; however, regs from different locations lead to clinical outcomes. Our aim was, therefore, compare the prevalences suppressive phenotypes of peripheral blood, peritumor, intratumor patients with hepatocellular carcinoma HCC ). Methods The frequencies CD 4 + 25 127 low/− 49d − Tregs periphery, 78 12 healthy controls were evaluated by flow cytometry. reg‐cell activity was determined using an...
Abstract Background Skeletal muscle is the largest tissue in body, and it affects motion, metabolism homeostasis. development comprises myoblast proliferation, fusion differentiation to form myotubes, which subsequently mature fibres. This process strictly regulated by a series of molecular networks. Increasing evidence has shown that noncoding RNAs, especially microRNAs (miRNAs), play vital roles regulating skeletal growth. Here, we showed miR-668-3p highly expressed muscle. Methods...
Skeletal muscle, a vital and intricate organ, plays pivotal role in maintaining overall body metabolism, facilitating movement, supporting normal daily activities. An accumulating of evidence suggests that microRNA (miRNA) holds crucial orchestrating skeletal muscle growth. Therefore, the primary aim this study was to investigate influence miR-103-3p on myogenesis. In our study, overexpression found stimulate proliferation while suppressing differentiation C2C12 myoblasts. Conversely,...
<b><i>Background:</i></b> Intraoperative amino acid infusion can attenuate the decrease in core temperature, but metabolic effects are uncertain. <b><i>Methods:</i></b> Thirty-six healthy mongrel dogs undergoing ileectomy under general anesthesia were infused intraoperatively with normal saline or 18 compound acids at 6, 12, and 24 kJ·kg<sup>–1</sup>·h<sup>–1</sup> (NS, 6-, 12-, 24-kJ groups) studied until h after...
Abstract Glutathione-S-transferases mu 2 ( GSTM2 ), a kind of important Phase II antioxidant enzyme eukaryotes, is degraded by nonsense mediated mRNA decay due to C27T substitution in the fifth exon pigs. As reproductive performance-related gene, involved embryo implantation, whereas, functional deficiency induces pre- or post-natal death piglets potentially. To have some insight into role development, high throughput RNA sequencing performed using swine testis cells (ST) with deletion ....
MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules about 22 nucleotides in length and encoded by endogenous genes, involved the regulation post-transcriptional gene expression animals plants. Many studies have shown that microRNAs regulate development skeletal muscle, mainly manifested activation muscle satellite cells biological processes such as proliferation, differentiation, formation tubes. In this study, miRNA sequencing screening longissimus dorsi (LD,...
Cyp4a14 is a member of cytochrome P450 (Cyp450) enzyme superfamily that possesses NADPH monooxygenase activity, which catalyzes omega-hydroxylation medium-chain fatty acids and arachidonic acid. Study suggests down-regulation has an anti-inflammatory response in intestine. The present study was to test the function dextran sulfate sodium (DSS)-induced colitis.Female Cyp4a14-knockout (KO) wild-type (WT) mice were treated with DSS for 6 days induce colitis. colon histologically observed by...