A5101509100- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- stochastic dynamics and bifurcation
- Gastrointestinal motility and disorders
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Neural Networks and Applications
- Neuroscience, Education and Cognitive Function
- Gastrointestinal disorders and treatments
- Neurobiology and Insect Physiology Research
- Mental Health Research Topics
- Esophageal and GI Pathology
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Nonlinear Dynamics and Pattern Formation
- Helicobacter pylori-related gastroenterology studies
- Intestinal Malrotation and Obstruction Disorders
New York University
2016-2025
Shandong University
2014-2025
Mayo Clinic in Arizona
2018-2024
Mayo Clinic in Florida
2019-2024
University of Connecticut
2013-2024
WinnMed
2018-2024
North China University of Science and Technology
2024
Mayo Clinic
2018-2023
Guizhou University
2023
Hunan University of Technology
2023
Fast neuronal oscillations (gamma, 20–80 Hz) have been observed in the neocortex and hippocampus during behavioral arousal. Using computer simulations, we investigated hypothesis that such rhythmic activity can emerge a random network of interconnected GABAergic fast-spiking interneurons. Specific conditions for population synchronization, on properties single cells circuit, were identified. These include following: (1) amplitude spike afterhyperpolarization be above GABA A synaptic reversal...
Recent physiological studies using behaving monkeys revealed that, in a two-alternative forced-choice visual motion discrimination task, reaction time was correlated with ramping of spike activity lateral intraparietal cortical neurons. The appears to reflect temporal accumulation, on timescale hundreds milliseconds, sensory evidence before decision is reached. To elucidate the cellular and circuit basis such integration times, we developed investigated simplified two-variable version...
When the local field potential of a cortical network displays coherent fast oscillations ( approximately 40-Hz gamma or 200-Hz sharp-wave ripples), spike trains constituent neurons are typically irregular and sparse. The dichotomy between rhythmic stochastic presents challenge to theory brain rhythms in framework coupled oscillators. Previous studies have shown that when noise is large recurrent inhibition strong, rhythm can be generated while single fire intermittently at low rates compared...
Delay-period activity of prefrontal cortical cells, the neural hallmark working memory, is generally assumed to be sustained by reverberating synaptic excitation in circuit. Previous model studies memory emphasized high efficacy recurrent synapses, but did not investigate role temporal dynamics. In this theoretical work, I show that biophysical properties transmission are important generation and stabilization a network persistent state. This especially case when negative feedback mechanisms...
We study pacemaker rhythms generated by two nonoscillatory model cells that are coupled inhibitory synapses. A minimal ionic exhibits postinhibitory rebound (PIR) is presented. When the post-synaptic conductance depends instantaneously on presynaptic potential classical alternating rhythm obtained. Using phase-plane analysis we identify underlying mechanisms, “release” and “escape,” for out-of-phase oscillation. postsynaptic not instantaneous but decays slowly, can oscillate synchronously...
Theta frequency field oscillation reflects synchronized synaptic potentials that entrain the discharge of neuronal populations within ≈100–200 ms range. The cellular-synaptic generation theta activity in hippocampus was investigated by intracellular recordings from somata and dendrites CA1 pyramidal cells urethane-anesthetized rats. recorded neurons were verified injection biocytin. Transition non-theta to state characterized a large decrease input resistance neuron (39% soma), tonic somatic...
Slow oscillatory activity (<1 Hz) is observed in vivo the cortex during slow-wave sleep or under anesthesia and vitro when bath solution chosen to more closely mimic cerebrospinal fluid. Here we present a biophysical network model for slow oscillations that reproduces single neuron behaviors collective firing patterns control as well pharmacological manipulations. The membrane potential of oscillates slowly (at <1 between down state an up state; maintained by strong recurrent...