A5054673367- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Motor Control and Adaptation
- Advanced Memory and Neural Computing
- Neurotransmitter Receptor Influence on Behavior
- Muscle activation and electromyography studies
- Decision-Making and Behavioral Economics
- Neuroscience, Education and Cognitive Function
- Neural Networks and Reservoir Computing
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Cognitive Science and Mapping
- Creativity in Education and Neuroscience
- Gender Diversity and Inequality
- Complex Systems and Time Series Analysis
- Horticultural and Viticultural Research
- Primate Behavior and Ecology
- Cognitive and developmental aspects of mathematical skills
- Diversity and Career in Medicine
University of California, Berkeley
2016-2025
Neuroscience Institute
2019
Bridge University
2012
University of Cambridge
2001-2012
Massachusetts Institute of Technology
2001-2003
Abstract An important function of the prefrontal cortex (PFC) is control goal‐directed behaviour. This requires information as to whether actions were successful in obtaining desired outcomes such rewards. While lesion studies implicate a particular PFC region, orbitofrontal (OFC), reward processing, neurons encoding have been reported both OFC and dorsolateral (DLPFC). To compare contrast their roles, we recorded simultaneously from areas while two rhesus monkeys ( Macaca mulatta )...
A central question in behavioral science is how we select among choice alternatives to obtain consistently the most beneficial outcomes. Three variables are particularly important when making a decision: potential payoff, probability of success, and cost terms time effort. key brain region decision frontal cortex as damage here impairs ability make optimal choices across range types. We simultaneously recorded activity multiple single neurons while subjects made involving three...
Hebb proposed that neuronal cell assemblies are critical for effective perception, cognition, and action. However, evidence brain mechanisms coordinate multiple coactive remains lacking. Neuronal oscillations have been suggested as one possible mechanism assembly coordination. Prior studies shown spike timing depends upon local field potential (LFP) phase proximal to the body, but few examined dependence of spiking on distal LFP phases in other areas far from neuron or influence LFP-LFP...
Behavior is often governed by abstract rules or instructions for behavior that can be abstracted from one context and applied to another. Prefrontal cortex (PFC) thought important representing rules, although the contributions of ventrolateral (VLPFC) dorsolateral (DLPFC) regions remain under-specified. In present study, event-related fMRI was used examine rule representation in humans. Prior scanning, subjects learned associate unfamiliar shapes nonwords with particular rules. During each...
The ability to use abstract rules or principles allows behavior generalize from specific circumstances (e.g., learned in a restaurant can subsequently be applied any dining experience). Neurons the prefrontal cortex (PFC) encode such rules. However, guide behavior, must linked motor responses. We investigated neuronal mechanisms underlying this process by recording PFC and premotor (PMC) of monkeys trained two rules: "same" "different." had either hold release lever, depending on whether...
Abstract Damage to the frontal lobe can cause severe decision‐making impairments. A mechanism that may underlie this is neurons in cortex encode many variables contribute valuation of a choice, such as its costs, benefits and probability success. However, optimal requires one considers these variables, not only when faced with but also evaluating outcome order adapt future behaviour appropriately. To examine role encoding value different choice outcomes, we simultaneously recorded activity...
The ability to use abstract rules or principles allows behavior generalize from specific circumstances. We have previously shown that such are encoded in the lateral prefrontal cortex (PFC) and premotor (PMC). Here, we extend these investigations two other areas directly connected with PFC PMC, inferior temporal (ITC) dorsal striatum (STR). Monkeys were trained rules: "same" "different". They had either hold release a lever, depending on whether successively presented pictures same...
A fundamental organizational principle of the primate motor system is cortical control contralateral limb movements. Motor areas also appear to play a role in ipsilateral Several studies monkeys have shown that individual neurons primary cortex (M1) may represent, on average, direction movements arm. Given increasing body evidence demonstrating neural ensembles can reliably represent information with high temporal resolution, here we characterize distributed representation upper kinematics...
Abstract Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons or dynamic (time-varying) across a neural population. Here, we compare these hypotheses four regions of prefrontal cortex (PFC) an oculomotor-delayed-response task, where intervening cue indicated the reward available for correct saccade. WM representations were strongest ventrolateral PFC with higher intrinsic temporal stability (time-constant). At population-level,...