A5100633410- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Nuclear Structure and Function
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- FOXO transcription factor regulation
- NF-κB Signaling Pathways
- Phytoestrogen effects and research
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- Curcumin's Biomedical Applications
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Developmental Biology and Gene Regulation
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- PARP inhibition in cancer therapy
- Cancer Mechanisms and Therapy
First Affiliated Hospital of Zhengzhou University
2024-2025
Zhengzhou University
2024-2025
Fudan University
2007-2025
Wuhan University
2022-2025
Wayne State University
2015-2024
The Barbara Ann Karmanos Cancer Institute
2014-2024
Ningxia Medical University
2024
University of Georgia
2023
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2022
United States Food and Drug Administration
2022
To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection.CD3+, CD4+, CD8+, Foxp3-positive, and granzyme B-positive TILs were assessed by immunohistochemistry tissue microarrays containing HCC from 302 patients. Prognostic effects low- or high-density TIL subsets evaluated Cox regression Kaplan-Meier analysis using median values as cutoff.CD3+, CD8+ associated with neither...
Abstract Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, part, de novo and acquired chemoresistance radioresistance. Gemcitabine alone or combination with other conventional therapeutics is standard care for treatment advanced PC without any significant improvement overall survival patients diagnosed this deadly disease. Previous studies have shown that cells are gemcitabine-resistant (GR) epithelial-mesenchymal...
The aggressive course of pancreatic cancer is believed to reflect its unusually invasive and metastatic nature, which associated with epidermal growth factor receptor (EGFR) overexpression NF-kappaB activation. MicroRNAs (miRNA) have been implicated in the regulation various pathobiological processes cancer, including metastasis other human malignancies. In this study, we report lower expression miR-146a cells compared normal duct epithelial cells. Reexpression inhibited capacity concomitant...
Abstract Cancer chemotherapeutic strategies commonly require multiple agents. However, use of agents contributes to added toxicity resulting in poor treatment outcome. Thus, combination chemotherapy must be optimized increase tumor response and at the same time lower its toxicity. Chemotherapeutic are known induce nuclear factor κB (NF-κB) activity cells, cell killing drug resistance. In contrast, genistein has been shown inhibit NF-κB growth various cancer cells without causing systemic We...
Abstract Pancreatic cancer is the fourth leading cause of cancer-related deaths in United States, which is, part, due to intrinsic (de novo) and extrinsic (acquired) resistance conventional therapeutics, suggesting that innovative treatment strategies are required for overcoming therapeutic improve overall survival patients. Oral administration metformin patients with diabetes mellitus has been reported be associated reduced risk pancreatic kill stem cells (CSC); however, exact molecular...
Abstract MicroRNAs have been implicated in tumor progression. Recent studies shown that the miR-200 family regulates epithelial–mesenchymal transition (EMT) by targeting zinc-finger E-box binding homeobox 1 (ZEB1) and ZEB2. Emerging evidence from our laboratory others suggests processes of EMT can be triggered various growth factors, such as transforming factor β platelet-derived factor-D (PDGF-D). Moreover, we recently reported overexpression PDGF-D prostate cancer cells (PC3 cells) leads...
Abstract The histone methyltransferase EZH2 is a central epigenetic regulator of cell survival, proliferation, and cancer stem (CSC) function. expression increased in various human cancers, including highly aggressive pancreatic but the mechanisms underlying for its biologic effects are not yet well understood. In this study, we probed function using diflourinated-curcumin (CDF), novel analogue turmeric spice component curcumin that has antioxidant properties. CDF decreased clonogenicity,...
Abstract Pancreatic cancer remains the fourth most common cause of cancer-related death in United States. Notch signaling plays a critical role maintaining balance among cell proliferation, differentiation, and apoptosis, thereby may contribute to development pancreatic cancer. To characterize pathway function cells, we explored consequences down-regulation Notch-1 BxPC-3, HPAC, PANC-1 cells. Using multiple cellular molecular approaches such as...
Abstract Notch signaling plays a critical role in the pathogenesis and progression of human malignancies but precise mechanism Notch-1 for tumor invasion remains unclear. In our earlier report, we showed that down-regulation reduced nuclear factor-κB (NF-κB) DNA-binding activity matrix metalloproteinase-9 (MMP-9) expression. Because NF-κB, VEGF, MMPs are critically involved processes cell metastasis, investigated mechanism(s) by which (using molecular approaches) may lead to vascular...
Abstract BACKGROUND Notch signaling plays a critical role in maintaining the balance between cell proliferation, differentiation, and apoptosis, thereby may contribute to development of pancreatic cancer. Therefore, down‐regulation be novel approach for cancer therapy. It has been reported that curcumin down‐regulates many genes are known promote survival also up‐regulates promoters apoptosis cells vitro. there is cross‐talk Notch‐1 another major growth apoptotic regulatory pathway, nuclear...
Abstract The Forkhead Box M1 (FoxM1) transcription factor has been shown to play important roles in regulating the expression of genes involved cell proliferation, differentiation, and transformation. Overexpression FoxM1 found a variety aggressive human carcinomas including pancreatic cancer. However, precise role molecular mechanism action cancer remain unclear. To elucidate cellular function FoxM1, we tested consequences down-regulation up-regulation cells, respectively. Using multiple...