A5072765154- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Curcumin's Biomedical Applications
- Histone Deacetylase Inhibitors Research
- FOXO transcription factor regulation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Hedgehog Signaling Pathway Studies
- Prostate Cancer Treatment and Research
- Synthesis and biological activity
- Tea Polyphenols and Effects
- Metabolism, Diabetes, and Cancer
- Renal and related cancers
Hamad Medical Corporation
2021-2025
Northwestern University
2025
Wright State University
2025
Integral University
2023-2024
University of New Mexico
2024
The Barbara Ann Karmanos Cancer Institute
2010-2023
Wayne State University
2011-2023
University of Alabama at Birmingham
2019-2023
University of Alabama
2023
Hayatabad Medical Complex
2022
Abstract Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, part, de novo and acquired chemoresistance radioresistance. Gemcitabine alone or combination with other conventional therapeutics is standard care for treatment advanced PC without any significant improvement overall survival patients diagnosed this deadly disease. Previous studies have shown that cells are gemcitabine-resistant (GR) epithelial-mesenchymal...
Curcumin induces cancer cell growth arrest and apoptosis in vitro, but its poor bioavailability vivo limits antitumor efficacy. We have previously evaluated the of novel analogues curcumin compared with curcumin, we found that analogue CDF exhibited greater systemic pancreatic tissue bioavailability. In this study, effects or alone combination gemcitabine on viability gemcitabine-sensitive gemcitabine-resistant (PC) lines. Mechanistic investigations revealed a significant reduction...
Background Current management of patients diagnosed with prostate cancer (PCa) is very effective; however, tumor recurrence Castrate Resistant Prostate Cancer (CRPC) and subsequent metastasis lead to poor survival outcome, suggesting that there a dire need for novel mechanistic understanding recurrence, which would be critical designing therapies. The the PCa are tightly linked biology stem cells or cancer-initiating reminiscent acquisition Epithelial Mesenchymal Transition (EMT) phenotype....
Abstract Pancreatic cancer is the fourth leading cause of cancer-related deaths in United States, which is, part, due to intrinsic (de novo) and extrinsic (acquired) resistance conventional therapeutics, suggesting that innovative treatment strategies are required for overcoming therapeutic improve overall survival patients. Oral administration metformin patients with diabetes mellitus has been reported be associated reduced risk pancreatic kill stem cells (CSC); however, exact molecular...
Abstract MicroRNAs have been implicated in tumor progression. Recent studies shown that the miR-200 family regulates epithelial–mesenchymal transition (EMT) by targeting zinc-finger E-box binding homeobox 1 (ZEB1) and ZEB2. Emerging evidence from our laboratory others suggests processes of EMT can be triggered various growth factors, such as transforming factor β platelet-derived factor-D (PDGF-D). Moreover, we recently reported overexpression PDGF-D prostate cancer cells (PC3 cells) leads...
Abstract The histone methyltransferase EZH2 is a central epigenetic regulator of cell survival, proliferation, and cancer stem (CSC) function. expression increased in various human cancers, including highly aggressive pancreatic but the mechanisms underlying for its biologic effects are not yet well understood. In this study, we probed function using diflourinated-curcumin (CDF), novel analogue turmeric spice component curcumin that has antioxidant properties. CDF decreased clonogenicity,...
FoxM1 is known to play important role in the development and progression of many malignancies including pancreatic cancer. Studies have shown that acquisition epithelial-to-mesenchymal transition (EMT) phenotype induction cancer stem cell (CSC) or stem-like phenotypes are highly inter-related, contributes drug resistance, tumor recurrence, metastasis. The molecular mechanism(s) by which EMT CSC self-renewal capacity poorly understood. Therefore, we established over-expressing (AsPC-1) cells,...
Abstract Notch signaling is involved in a variety of cellular processes, such as cell fate specification, differentiation, proliferation, and survival. Notch‐1 over‐expression has been reported prostate cancer metastases. Likewise, ligand Jagged‐1 was found to be over‐expressed metastatic compared localized or benign prostatic tissues, suggesting the biological significance progression. However, mechanistic role consequence its down‐regulation have not fully elucidated. Using multiple...
Abstract Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) plays an important role in glycolysis and gluconeogenesis is associated with invasion metastasis of cancer cells. We have previously shown its the induction epithelial-mesenchymal transition (EMT) breast cells, which led to increased aggressiveness; however, molecular mechanism by PGI/AMF regulates EMT not known. Here we show, for first time, that overexpression increase DNA-binding activity NF-κB, which, turn, expression...