A5100449992- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Microbial Metabolites in Food Biotechnology
- Ion Channels and Receptors
- Food composition and properties
- Cancer-related Molecular Pathways
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Neurobiology and Insect Physiology Research
- Hypothalamic control of reproductive hormones
- Trace Elements in Health
- MicroRNA in disease regulation
- Nicotinic Acetylcholine Receptors Study
- Biofuel production and bioconversion
- Metabolomics and Mass Spectrometry Studies
- Genetic Neurodegenerative Diseases
- Genomics and Phylogenetic Studies
Jiangnan University
2019-2025
Southeast University
2024
Kunming Children's Hospital
2024
Luoyang Institute of Science and Technology
2024
Northwest A&F University
2024
Guizhou University
2024
Wuhan University
2019-2024
Henan University of Science and Technology
2024
The University of Texas at San Antonio
2023
Chinese PLA General Hospital
2020-2022
Abstract Pancreatic cancer is the fourth leading cause of cancer-related deaths in United States, which is, part, due to intrinsic (de novo) and extrinsic (acquired) resistance conventional therapeutics, suggesting that innovative treatment strategies are required for overcoming therapeutic improve overall survival patients. Oral administration metformin patients with diabetes mellitus has been reported be associated reduced risk pancreatic kill stem cells (CSC); however, exact molecular...
We have recently shown that Neuropeptide S (NPS) can promote arousal and induce anxiolytic-like effects after central administration in rodents. Another study reported a number of natural polymorphisms the human NPS receptor gene. Some these were associated with increased risk asthma possibly other forms atopic diseases, but physiological consequences mutations remain unclear. One produces an Asn-Ile exchange first extracellular loop protein, C-terminal splice variant was found overexpressed...
Endothelial dysfunction, characterized by a decline in endothelial physiological functions, is significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), key member Ca
Key points Melanin‐concentrating hormone (MCH) neurons express histamine‐3 receptor (H3R) mRNA but not histamine‐1 (H1R) or histamine‐2 (H2R) mRNA. Histamine inhibits MCH by activating postsynaptic H3R. This effect is mediated through G protein‐dependent inwardly rectifying potassium (GIRK) channels. may function to silence during wakefulness. Abstract (MCH)‐producing are known regulate a wide variety of physiological functions such as feeding, metabolism, anxiety and depression, reward....
Puerarin derived from<italic>Pueraria</italic>induces mesenteric endothelium-dependent vasodilation involving the TRPV4-IK<sub>Ca</sub>/SK<sub>Ca</sub>pathway, exhibiting antihypertensive activity against high-salt-induced hypertension.
Abstract Hydroxycarboxylic acids are crucial metabolic intermediates involved in various physiological and pathological processes, some of which recognized by specific hydroxycarboxylic acid receptors (HCARs). HCAR2 is one such receptor, activated endogenous β-hydroxybutyrate (3-HB) butyrate, the target for Niacin. Interest has been driven its potential as a therapeutic cardiovascular neuroinflammatory diseases. However, limited understanding how ligands bind to this receptor hindered...
In the study, gas chromatography/time-of-flight mass spectrometry (GC/TOFMS) techniques coupled with principal components analysis (PCA) were used to investigate metabolite perturbations in serum of rats exposed 0.75, 3 or 8 Gy gamma rays. Male standard deviation gamma-irradiated at doses and (1.9 min(-1)) sham-irradiated. Serum samples collected over first 24 h under exposure irradiation order analyse by GC/TOFMS. And multivariate data analysed PCA. The composition metabolites yielded...
Paeonia suffruticosa Andr. (tree peony) and lactiflora Pall. (herbaceous are traditional Chinese flowers with great ornamental value. To maintain the aesthetic value show characteristics of these species, preserved named ‘germplasm display balls’ were developed. Firstly, dried obtained by vacuum freeze-drying. Secondly, to embed develop germplasm balls, highly transparent crystal glue (in wrapped balls type 1 drop-type 2) silicone gel 3) used. Finally, first pass yield (FPY), labor...
BACKGROUND: Vascular calcification contributes to increased cardiovascular morbidity and mortality in patients with chronic kidney disease, diabetes, atherosclerosis. Currently, there are no effective therapeutic strategies prevent or reverse vascular calcification. TRPV4 (transient receptor potential channel V4), a key Ca 2+ -permeable channel, plays an important role various diseases. However, the mechanism of have not yet been elucidated. METHODS: The effects on were explored vitro vivo....
Cytosine base editors (CBEs) show promise for multiplex gene knockout applications, but impure edits, indels and off-targets still frequently occur. We describe here QBEmax, which exhibits high efficiency, low indel product purity with up to 99.8% of edits comprised C-to-T. Through molecular dynamic modeling, QBEmax presents as a compact stable editor that shields protected bases from undesired repair processes.
Abstract In the rat, neuropeptide B/neuropeptide W (NPB/NPW) system is composed of two ligands, B (NPB) and (NPW), one receptor, GPR7. Although preliminary analyses show roles in feeding, hormone secretion, analgesia, lack a detailed anatomical map impairs our understanding NPB/NPW system. We demonstrate this report expression patterns GPR7, NPB, NPW precursor messenger ribonucleic acid (mRNA) rat brain by using situ hybridization binding experiments. The amygdala expresses highest levels...
MicroRNAs (miRNAs) play a prominent role in post-transcriptional gene expression regulation and have been involved various biological metabolic processes to regulate expression. For Brassica napus, improving seed-weight oil-content is the main breeding goal. In order better understand mechanism of miRNAs during formation accumulation B. this study, high-throughput sequencing technology was used profile napus immature seeds from one six weeks after flowering. A total 1,276 miRNAs, including...
Reduced NO levels and activity are signs of endothelial dysfunction, which is important in mediating BP changes. Previously, we demonstrated that transient receptor potential channel V4 (TRPV4) could form a functional complex with other proteins to mediate vasodilation cells (ECs). But how TRPV4 interacts the pathway larger arteries requires further exploration.We used single-cell RNA-sequencing find CD106+ TRPV4high NOS3high ECs. The TRPV4-eNOS interaction was verified by...