A5101984464- Remote-Sensing Image Classification
- Ion Channels and Receptors
- Remote Sensing and Land Use
- Atherosclerosis and Cardiovascular Diseases
- Advanced Image Fusion Techniques
- Toxin Mechanisms and Immunotoxins
- Land Use and Ecosystem Services
- Advanced Image and Video Retrieval Techniques
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Sodium Intake and Health
- Herpesvirus Infections and Treatments
- Inertial Sensor and Navigation
- Biochemical Analysis and Sensing Techniques
- Remote Sensing in Agriculture
- Advanced Vision and Imaging
- Phytochemicals and Antioxidant Activities
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Bioinformatics and Genomic Networks
- Breast Cancer Treatment Studies
- Remote Sensing and LiDAR Applications
- Hydrocarbon exploration and reservoir analysis
- Gene expression and cancer classification
- Robotics and Sensor-Based Localization
Jiangnan University
2012-2024
Hohai University
2024
University of Alberta
2019
Harbin Engineering University
2019
Chinese Academy of Sciences
2012-2018
Institute of Remote Sensing and Digital Earth
2014-2018
Shengli Oilfield Central Hospital
2015-2017
Cereal Research (Hungary)
2014-2016
Dongfang Electric Corporation (China)
2016
Wuxi Institute of Technology
2014
Significance A critical challenge for chemotherapy is development of chemoresistance, but underlying molecular mechanisms remain unclear. In this study, we found that drug-resistant adriamycin-resistant human breast cancer cells possessed numerous transient receptor potential channel 5 (TrpC5) -containing extracellular vesicles (EVs) on the cell surface. Suppressing TrpC5 expression diminished formation EVs. Incubation drug-sensitive recipient with EVs endowed recipients properties. both...
An attractive strategy to overcome multidrug resistance in cancer chemotherapy is suppress P-glycoprotein (P-gp), which a pump overproduced cells remove cytotoxic drugs from cells. In the present study, Ca 2+ -permeable channel TRPC5 was found be together with P-gp adriamycin-resistant breast cell line MCF-7/ADM. Suppressing activity/expression reduced induction and caused remarkable reversal of adriamycin an athymic nude mouse model human tumor, suppressing decreased growth tumor...
To investigate the role of microRNAs in development chemoresistance and related epithelial–mesenchymal transition (EMT), we examined effect miR‐489 adriamycin (ADM)‐resistant human breast cancer cells (MCF‐7/ADM). MiR‐489 was significantly suppressed MCF‐7/ADM compared with chemosensitive parental control MCF‐7/WT cells. Forced‐expression reversed chemoresistance. Furthermore, Smad3 identified as target is highly expressed Forced expression both inhibited EMT properties. Finally,...
A satellite image time series (SITS) contains a significant amount of temporal information. By analysing this type data, the pattern changes in object concern can be explored. The natural change Earth’s surface is relatively slow and exhibits pronounced pattern. Some events (for example, fires, floods, plant diseases, insect pests) human activities deforestation urbanisation) will disturb cause profound on surface. These are usually referred to as disturbances. However, disturbances...
Dysregulation of microRNA is strongly implicated in the chemoresistance cancer. In this study, we found that miR-149 was downregulated and involved adriamycin (ADM)-resistant human breast cancer cells (MCF-7/ADM). Downregulation related to hypermethylation its 5'-UTR; methylation also affected expression glypican 1 gene, which both host target gene miR-149. Furthermore, modulated through targeting GlcNAc N-deacetylase/N-sulfotransferase-1 (NDST1). With miR-149, NDST1 increased chemoresistant...
BACKGROUND AND PURPOSE Transient receptor potential vanilloid 4 (TRPV4) is a Ca 2+ ‐permeable channel with multiple modes of activation. Apigenin plant‐derived flavone, which has preventive effects on the development cardiovascular disease. We set out to explore apigenin TRPV4 activity and its role in vasodilatation. EXPERIMENTAL APPROACH The (0.01–30 µM) TPRV4 channels were investigated HEK293 cells over‐expressing TRPV4, rat primary cultured mesenteric artery endothelial (MAECs) isolated...
We previously demonstrated that the overexpression of transient receptor potential channel C5 (TRPC5) and nuclear factor activated T-cells isoform c3 (NFATC3) are essential for cancer chemoresistance, but how TRPC5 NFATC3 regulated was still unclear. In this study, microRNA 320a (miR-320a) found to be down-regulated in chemoresistant cells. MiR-320a directly targeted NFATC3, down-regulation miR-320a triggered overexpression. cells, associated with regulation by methylation, which implicated...
Semantic-level land-use scene classification is a challenging problem, in which deep learning methods, e.g., convolutional neural networks (CNNs), have shown remarkable capacity. However, lack of sufficient labeled images has proved hindrance to increasing the accuracy CNNs. Aiming at this paper proposes CNN pre-training method under guidance human visual attention mechanism. Specifically, computational model used automatically extract salient regions unlabeled images. Then, sparse filters...
The currently available antihypertensive agents have undesirable adverse effects due to systemically altering target activity including receptors, channels, and enzymes. These effects, such as loss of potassium ions induced by diuretics, bronchospasm beta-blockers, constipation Ca2+ channel blockers, dry cough ACEI, lead non-compliance with therapies (Moser, 1990). Here, based on new hypertension mechanisms, we explored a approach. We report that transient receptor potential vanilloid 4...
The aorta, with ascending, arch, thoracic and abdominal segments, responds to the heartbeat, senses metabolites distributes blood all parts of body. However, heterogeneity across aortic segments how metabolic pathologies change it are not known. Here, a total 216 612 individual cells from ascending mouse aortas under normal conditions or high glucose levels, dietary salt, fat intake were profiled using single-cell RNA sequencing. We generated compendium 10 distinct cell types, mainly...
Transient receptor potential channel 5 (TrpC5) is a member of the TrpC subgroup, and it forms receptor-activated, non-selective Ca2+ channel. The architecture TrpC5 poorly understood. In present study, we report that key factor in regulating differentiation colorectal cancer (CRC). Through study specimens from large cohort patients with CRC, found was highly expressed its cellular level correlated tumour grade. We showed further up-regulated caused robust rise intracellular calcium...
TRPC1 channel facilitates virus infection.
Reduced NO levels and activity are signs of endothelial dysfunction, which is important in mediating BP changes. Previously, we demonstrated that transient receptor potential channel V4 (TRPV4) could form a functional complex with other proteins to mediate vasodilation cells (ECs). But how TRPV4 interacts the pathway larger arteries requires further exploration.We used single-cell RNA-sequencing find CD106+ TRPV4high NOS3high ECs. The TRPV4-eNOS interaction was verified by...
In this paper, we propose a novel method to continuously monitor land cover change using satellite image time series, which can extract comprehensive information including time, location, and “from-to” information. This is based on hidden Markov model (HMM) trained for each class. Assuming pixel’s initial class has been obtained, likelihoods of the corresponding are calculated incoming series extracted with temporal sliding window. By observing likelihood over windows, be precisely detected...
// Dong-Xu He 1, * , Guo-Hong Li 2, Xiao-Ting Gu Liang Zhang 1 Ai-Qin Mao Juan Wei De-Quan Liu 3 Gui-Yang Shi Xin Ma School of Pharmaceutical Sciences National Engineering, and Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China 2 Conservation Utilization Bio-Resources, Key Microbial Resources The Ministry Education, Yunnan Kunming 650091, Department Breast Surgery, Third Affiliated Hospital, Medical 650031, These authors have contributed equally to this...
High-fat diet (HFD) induces dysregulated pathways in coronary artery endothelial cells (CAECs), which leads to altered regulation of vascular tone, tissue perfusion and increases the risk diseases. Ca2+ -activated K+ (KCa ) channels are known be associated with transient receptor potential (TRP) channels, important for regulating function. But how TRPV4 interacts KCa tone HFD mice requires further exploration.TRPV4 channel activity was assessed by fluorescent imaging. Interactions between...
Single-cell RNA-Seq analysis can determine the heterogeneity of cells between different tissues at a single-cell level. Coronary artery endothelial (ECs) are important to coronary blood flow. However, little is known about ECs, and cellular identity responses Identifying subpopulations will contribute precise localization vascular subpopulations, thus enabling precision injury treatment.
A sponge city is an established urban stormwater management approach that effectively reduces runoff and pollutant discharges. In order to plan design, estimate costs, evaluate the performance of systems, it essential calculate storage scale. this context, a scale calculation method based on multifactor spatial overlay was designed, utilising starting area Dafeng Hi-tech Development Zone in Yancheng City, China, as illustrative example. The indicators for assessing impact systems river plain...