A5015078046- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acupuncture Treatment Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Healthcare and Venom Research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Blood properties and coagulation
- Drug Transport and Resistance Mechanisms
- Proteoglycans and glycosaminoglycans research
- Pancreatic function and diabetes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Retinal and Optic Conditions
- Diabetes and associated disorders
Inserm
2009-2025
Université Sorbonne Paris Nord
2019-2025
Université Paris Cité
2006-2025
Anhui University of Traditional Chinese Medicine
2008-2025
Shenyang Agricultural University
2023-2025
Air Force Medical University
2024
Xuzhou Medical College
2023-2024
Nanjing Drum Tower Hospital
2009-2024
Soochow University
2023-2024
University of South China
2023-2024
Detection Transformer (DETR) and Deformable DETR have been proposed to eliminate the need for many hand-designed components in object detection while demonstrating good performance as previous complex hand-crafted detectors. However, their on Video Object (VOD) has not well explored. In this paper, we present TransVOD, first end-to-end video system based simple yet effective spatial-temporal architectures. The goal of paper is streamline pipeline current VOD, effectively removing feature...
Overexpression of RhoA or RhoC in breast cancer indicates a poor prognosis, due to increased tumor cell proliferation and invasion tumor-dependent angiogenesis. Until now, the strategy blockage Rho-signaling pathway has used either GGTI HMG-CoA reductase inhibitors, but they are not specific inhibition. In this study, new approach with anti-RhoA anti-RhoC siRNAs was inhibit specifically synthesis. Two transfections siRNA (8.5 nM) into MDA-MB-231 human cells HMEC-1 endothelial induced...
The antitumoral effects that follow the local delivery of N-terminal fragment human plasminogen (angiostatin K3) have been studied in two xenograft murine models. Angiostatin was achieved by a defective adenovirus expressing secretable angiostatin K3 molecule from cytomegalovirus promoter (AdK3). In vitro studies, AdK3 selectively inhibited endothelial cell proliferation and disrupted G 2 /M transition induced M-phase-promoting factors. AdK3-infected cells showed marked mitosis arrest...
Angiogenesis is essential for tumor growth and metastasis. In the process of angiogenesis, interaction between adhesive proteins endothelial cells extracellular matrix components plays an important role by mediating cell attachment, which indispensable their motility, transmitting regulatory signals locomotion proliferation. this study, we examined hypothesis that CD44 expressed on surface involved in angiogenesis process. The experiments using calf pulmonary artery (CPAE) a human...
HYPB is a human histone H3 lysine 36 (H3K36)-specific methyltransferase and acts as the ortholog of yeast Set2. This study explored physiological function mammalian using knockout mice. Homozygous disruption Hypb impaired H3K36 trimethylation but not mono- or dimethylation, resulted in embryonic lethality at E10.5-E11.5. Severe vascular defects were observed Hypb(-/-) embryo, yolk sac, placenta. The abnormally dilated capillaries mutant embryos sacs could be remodeled into large blood...
Recently, DETR and Deformable have been proposed to eliminate the need for many hand-designed components in object detection while demonstrating good performance as previous complex hand-crafted detectors. However, their on Video Object Detection (VOD) has not well explored. In this paper, we present TransVOD, an end-to-end video model based a spatial-temporal Transformer architecture. The goal of paper is streamline pipeline VOD, effectively removing feature aggregation, e.g., optical flow,...
Abstract Aim The association between composite dietary antioxidant index (CDAI) and diabetes remains unknown. Our study was to investigate the of CDAI with diabetes. Methods A total 11,956 participants were enrolled from National Health Nutrition Examination Surveys (NHANES). calculated intake six antioxidants. Multivariable logistic regressions performed explore associations prevalence glycemic index. Non-linear explored using restricted cubic splines. Results In multivariate regression...
Rho GTPases are involved in cellular functions relevant to cancer. The roles of RhoA and Rac1 have already been established. However, the role Rac3 cancer aggressiveness is less well understood. This work was conducted analyze implication two breast cell lines, MDA-MB-231 MCF-7: both express Rac3, but expresses more activated RhoA. effect cells also compared with its on non-tumorigenic mammary epithelial MCF-10A. We analyzed consequences depletion by anti-Rac3 siRNA. Firstly, we effects...
Background/Aims: Pancreatic cancer (PC) is an aggressive malignancy with a poor survival rate. Despite advances in the treatment of PC, efficacy therapy limited by development chemoresistance. Here, we examined role microRNA-29c (miR-29c) and involvement autophagy apoptosis chemoresistance PC cells vivo vitro. Methods: We employed qRT-PCR, western blot immunofluorescence to examine expression level miR-29c, USP22 relative protein. In addition, used MTT assay detect cell proliferation...
Abstract Despite the widespread adoption of emergency coronary reperfusion therapy, reperfusion‐induced myocardial injury remains a challenging issue in clinical practice. Following reperfusion, S100A8/A9 molecules are considered pivotal initiating and regulating tissue inflammatory damage. Effectively reducing level ischemic holds significant therapeutic value salvaging damaged myocardium. In this study, HA (hemagglutinin)‐ RAGE (receptor for advanced glycation end products)‐ comodified...
Abstract —Neovascularization of the atherosclerotic plaque is responsible for its weakening and consequently complications vascular disease. Macrophages are a source growth factors that can modulate angiogenesis. In this study, we analyzed effect oncostatin M (OSM) on angiogenesis, as it could be involved in development atherosclerosis. The OSM was compared with those leukemia inhibitory factor (LIF) interleukin-6 (IL-6). On human dermal microvasculature endothelial cells (HMEC-1s), (22.5 to...
The objective of the present study was to evaluate antitumor effect a defective adenovirus expressing secretable angiostatin-like molecule (AdK3) in combination with radiotherapy rat C6 gliomas s.c. preestablished into athymic mice. In vitro , regimen significantly ( P < 0.001) more cytotoxic for human microcapillary endothelial cells than either treatment alone, whereas survival glioma not affected conditions used. Radiotherapy and AdK3 gene delivery then studied on well established...
Abstract Apigenin is a widely distributed plant flavonoid and was proposed as an antitumor agent. In this study, we investigated the apigenin effects on protease-mediated invasiveness in estrogen-insensitive breast tumor cell line MDA-MB231. The results show that at 22.8-45.5 μM (2.5-10 μg/ml) strongly inhibited, dose-dependent manner, invasion through Matrigel, migration, proliferation. We treatment from 22.8 (2.5 led to partial decrease urokinase-plasminogen activator expression total...
Abstract Type IV collagenases are secreted as latent 92 and 72 kDa proenzymes which then activated extracellularly. The mechanisms by they in vivo not clear. We have studied the activation of porcine endothelial cell type tissue plasma kallikrein, found that kallikrein was a very efficient activator collagenase. Enzyme cleavage observed at concentrations low 0.1 μg/ml. Plasma had no effect. By comparison, plasmin, has been proposed to be physiological interstitial collagenase stromelysin,...
Abstract Metargidin, a transmembrane protein of the adamalysin family, and integrins, e.g., α5β1 αv, are preferentially expressed on endothelial cells angiogenesis. Furthermore, metargidin interacts with these integrins via its disintegrin domain. In this study, recombinant human domain (RDD) was produced in Escherichia coli by subcloning cDNA into pGEX-2T vector, effect purified RDD different steps angiogenesis evaluated. At concentrations 2–10 μg/ml, exhibited inhibitory activities variety...
Abstract Background Tissue factor (TF), an initiator of blood coagulation, participates in cancer progression and metastasis. We recently found that inhibition MAPK/ERK upregulated both full length TF (flTF) soluble isoform (asTF) gene expression cell-associated activity breast MDA-MB-231 cells. explored the possible mechanisms, especially interaction with EGFR PI3K/Akt pathways. Methods A plasmid containing promoter −2174 ~ +128 plus luciferase reporter was introduced into cells to evaluate...
The aim of this study was to elucidate the regulatory effect long non-coding RNA (lncRNA) ADAMTS9-AS2 on Tamoxifen (TAM) resistance in breast cancer (BC), and explore its underlying mechanism.TAM-resistant BC cell lines were first verified. Subsequently, proliferation apoptosis detected using counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU) assay flow cytometry, respectively. Protein levels ABCB1, ABCC1, ABCG2 TAM-treated MCF-7 MCF-7R cells determined by Western blot. expression...
Phase III multi-country studies (ZOE-50/70) demonstrated that the adjuvanted recombinant zoster vaccine (RZV) was well tolerated and prevented herpes (HZ) in healthy ≥ 50-year-olds, with a efficacy (VE) > 90% across age groups. These pivotal trials did not enroll participants from mainland China where RZV is licensed, therefore similar clinical data are missing for this population. In phase IV observer-blind study (NCT04869982) conducted between 2021 2023 China, immunocompetent medically...
TIMP-2 is a natural matrix metalloproteinase (MMP) inhibitor that prevents the degradation of extracellular proteins. It abolishes hydrolytic activity all activated members family and in particular MT1-MMP, MMP-2, MMP-9, which are selective for type IV collagenolysis. Since MMPs have been implicated both cancer progression angiogenesis, we generated recombinant adenovirus to deliver human (AdTIMP-2) evaluated its anticancer efficiency three murine models. Our results demonstrated...