A5089075056- Bipolar Disorder and Treatment
- Pneumonia and Respiratory Infections
- Schizophrenia research and treatment
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Electroconvulsive Therapy Studies
- Antibiotics Pharmacokinetics and Efficacy
- Head and Neck Cancer Studies
- Mental Health Treatment and Access
- Pharmacological Effects and Toxicity Studies
- Malaria Research and Control
- Urticaria and Related Conditions
- Antimicrobial Peptides and Activities
- Sepsis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Surgical site infection prevention
- vaccines and immunoinformatics approaches
- Child and Adolescent Psychosocial and Emotional Development
- Bacterial Identification and Susceptibility Testing
- Infection Control and Ventilation
- Immune Response and Inflammation
- Neuroscience and Music Perception
- Evolution and Genetic Dynamics
- Treatment of Major Depression
New York University
2024
GlaxoSmithKline (United States)
2024
Universities at Shady Grove
2024
University Medical Center Utrecht
2020-2023
Utrecht University
2020-2023
Johns Hopkins University
2023
AstraZeneca (United States)
2019-2022
University of Oxford
2022
Centre for Human Genetics
2022
King Fahad Hospital Jeddah
2022
Article AbstractBackground: We compared the prophylactic efficacy of lithium, carbamazepine, and combination identified possible clinical markers response. Method: Fifty-two outpatients who met DSM-III-R criteria for bipolar illness were randomly assigned in a double-blind design an intended 1 year treatment with lithium or crossover to opposite drug second year, then third on combination. Patients received monthly detailed evaluations, daily life chart ratings degree functional incapacity...
We explored the role of lyrics and melodies in conveying emotions songs. Participants rated intensity four types instrumental music or same paired with lyrics. Melodies conveyed intended emotion Experiments 1 3 but were mismatched 2 4. The major findings that detracted from happy calm (positive emotions), enhanced sad angry (negative emotions). In all cases, songs more dominant than eliciting emotions. addition, 4, appeared to transfer, simply by association, pictures common objects arbitrarily
Malaria transmission requires the production of male and female gametocytes in human host followed by fertilization sporogonic development mosquito midgut. Although essential for spread malaria through population, little is known about initiation gametocytogenesis vitro or vivo. Using a gametocyte-defective parasite line genetic complementation, we show that Plasmodium falciparum gametocyte 1 gene (Pfgdv1), encoding peri-nuclear protein, critical early sexual differentiation. Transcriptional...
MEDI3902 is a bivalent, bispecific human immunoglobulin G1κ monoclonal antibody that binds to both the Pseudomonas aeruginosa PcrV protein involved in host cell cytotoxicity and Psl exopolysaccharide P. colonization tissue adherence. being developed for prevention of nosocomial pneumonia high-risk patients.This phase 1 dose-escalation study (NCT02255760) evaluated safety, pharmacokinetics, antidrug (ADA) responses ex vivo anticytotoxicity opsonophagocytic killing activities after single...
Abstract It is well established that antibiotic treatment selects for resistance, but the dynamics of this process during infections are poorly understood. Here we map responses Pseudomonas aeruginosa to in high definition a lung infection single ICU patient. Host immunity and therapy with meropenem suppressed P. , second wave emerged due growth oprD wbpM resistant mutants evolved situ. Selection then led loss resistance by decreasing prevalence low fitness mutants, increasing frequency...
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...
Abstract Objectives To determine the susceptibility profiles and resistome of Pseudomonas aeruginosa isolates from European ICUs during a prospective cohort study (ASPIRE-ICU). Methods 723 respiratory samples or perianal swabs 402 patients 29 sites in 11 countries were studied. MICs 12 antibiotics determined by broth microdilution. Horizontally acquired β-lactamases analysed through phenotypic genetic assays. The first 105 providing such WGS, including analysis previously defined genotypic...
We evaluated MEDI8852, a human IgG1 monoclonal antibody that binds highly conserved influenza A hemagglutinin stalk epitope, in outpatients with uncomplicated infection. total of 126 subjects aged 18 to 65 years were enrolled during the 2015 2016 Northern and Southern Hemisphere seasons.
Speech-related changes in regional cerebral blood flow (rCBF) were measured using H(2)(15)O positron-emission tomography 9 adults with adductor spasmodic dysphonia (ADSD) before and after botulinum toxin (BTX) injection 10 age- gender-matched volunteers without neurological disorders. Scans acquired at rest during production of continuous narrative speech whispered speech. Speech was recorded scan acquisition for offline quantification voice breaks, pitch percentage aperiodicity to assess...
Phase III multi-country studies (ZOE-50/70) demonstrated that the adjuvanted recombinant zoster vaccine (RZV) was well tolerated and prevented herpes (HZ) in healthy ≥ 50-year-olds, with a efficacy (VE) > 90% across age groups. These pivotal trials did not enroll participants from mainland China where RZV is licensed, therefore similar clinical data are missing for this population. In phase IV observer-blind study (NCT04869982) conducted between 2021 2023 China, immunocompetent medically...
The adjuvanted recombinant zoster vaccine (RZV; Shingrix®, GSK) is a subunit that has been approved for the prevention of herpes in adults. Co-administration two vaccines single visit strategy to improve overall coverage. This review aims consolidate available clinical data on RZV co-administration, providing an overview safety, reactogenicity and immunogenicity. co-administration were obtained from five randomised, open-label, phase III trials with similar study designs. co-administered...
This investigation evaluated the relationship between changes in thyroid indices and mood stability during lithium carbamazepine prophylaxis for bipolar disorder.In first 2 years, 30 patients with disorder were randomly assigned to 1 year of then carbamazepine, or vice versa; third year, they received plus carbamazepine. By stepwise regression analysis, degree timing lithium- carbamazepine-induced their subsequent long-term evaluated.During phase, there was a significant inverse morbidity...
WE REPLICATED PREVIOUS FINDINGS AND DEMONSTRATED that familiarity with musical stimuli increased 'liking' or 'preference' for the stimuli. We also demonstrated intensity of emotional responses to music, but only when were made highly familiar through en masse repetitions (Experiment 3) rather than interspersed 1). In addition, ratings higher participants asked judge emotion conveyed by music they elicited same (Experiments 2 and 3). Finally, positive emotions (i.e., happy calm) rated...
<h3>Importance</h3> Carriage of<i>Staphylococcus aureus</i>is associated with<i>S aureus</i>infection. However, associations between<i>S aureus</i>carriage and the development of<i>S aureus</i>intensive care unit (ICU) pneumonia (SAIP) have not been quantified accurately, interpretation of available data is hampered because variations in definitions. <h3>Objective</h3> To quantify patient-related contextual factors, including<i>S aureus</i>colonization status, with occurrence SAIP....
The authors studied the efficacy of valproate plus lithium and triple therapy with lithium, carbamazepine, in refractory bipolar illness.The subjects were 24 outpatients who had completed an intended 3-year crossover study comparing their combination. Patients entered a 1-year phase because inadequate response or major side effects, patients responses offered additional year treatment all three mood-stabilizing drugs.Six (33%) 18 evaluable moderate to marked lithium; four these six not...
This study investigated the assets of daily prospective National Institute Mental Health Life-Chart Method (NIMH-LCM-p or LCM-p) for use in clinical trials bipolar disorder. Fifty-two outpatients, who met DSM-III-R criteria disorder, were randomly assigned a double-blind design to an intended 1 year treatment with lithium carbamazepine, crossover opposite drug second year, and then combination both agents third year. For each patient, LCM-p was initiated upon admission continued on basis....
This CME activity is expired. For more activities, visit CMEInstitute.com. Find articles on this and other psychiatry CNS topics: The Journal of Clinical Psychiatry Primary Care Companion for Disorders Article AbstractBackground: Development manic symptoms antidepressant discontinuation has primarily been reported in unipolar patients. case series presents preliminary evidence a similar phenomenon bipolar Method: Prospectively obtained life chart ratings 73 patients at the National Institute...
Objective To describe 2 cases of encephalitis with neuropsychiatric symptoms including catatonia, compounded by neuroleptic use for delirious agitation culminating in malignant catatonia responsive to electroconvulsive therapy (ECT). Background Neuropsychiatric can be manifestations limbic and encephalitides unidentified etiology, lethargica. Catatonic features are often difficult appraise this context. This easily lead the neuroleptics, which may precipitate worsening catatonia. Method...
The Plasmodium falciparum and P. berghei genomes each contain three dipeptidyl aminopeptidase (dpap) homologs. dpap1 -3 are critical for asexual growth, but the role of dpap2, gametocyte-specific homolog, has not been tested. If DPAPs essential transmission as well then a DPAP inhibitor could be used treatment to block transmission. To directly analyze DPAP2, dpap2-minus (Pbdpap2Δ) line was generated. Pbdpap2Δ parasites grew normally, differentiated into gametocytes, generated sporozoites...