Despoina Koulenti
A5019333952- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Renal function and acid-base balance
- Emergency and Acute Care Studies
- Fungal Infections and Studies
- Urinary Tract Infections Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Central Venous Catheters and Hemodialysis
- Vibrio bacteria research studies
- Mechanical Circulatory Support Devices
- Pleural and Pulmonary Diseases
- Patient Safety and Medication Errors
- Infectious Diseases and Mycology
- Clostridium difficile and Clostridium perfringens research
- Healthcare Decision-Making and Restraints
The University of Queensland
2016-2025
King's College Hospital NHS Foundation Trust
2024-2025
University General Hospital Attikon
2015-2024
University of Osijek
2015-2023
European Society of Intensive Care Medicine
2013-2023
European Society of Clinical Microbiology and Infectious Diseases
2019-2023
National and Kapodistrian University of Athens
2007-2022
Sağlık Bilimleri Üniversitesi
2022
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2022
University of Alberta
2022
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in achieves concentrations associated maximal activity affect patient outcome.This was prospective, multinational pharmacokinetic point-prevalence study including 8 antibiotics. Two blood samples were taken from each during single interval. The primary pharmacokinetic/pharmacodynamic targets free above the minimum inhibitory...
To describe the epidemiology of intra-abdominal infection in an international cohort ICU patients according to a new system that classifies cases setting acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized diffuse peritonitis), severity disease expression (infection, sepsis, septic shock). We performed multicenter (n = 309), observational, epidemiological study including adult diagnosed...
Objectives: Information on clinical practice regarding the diagnosis of pneumonia in European intensive care units is limited. The aim this study was to describe spectrum actual diagnostic practices a large sample units. Design: Prospective, observational, multicenter study. Setting: Twenty-seven nine countries. Patients: Consecutive patients requiring invasive mechanical ventilation for an admission or receiving >48 hrs irrespective diagnosis. Interventions: None. Measurements and Main...
We investigated the epidemiology of ventilator-associated pneumonia in elderly ICU patients. More precisely, we assessed prevalence, risk factors, signs and symptoms, causative bacterial pathogens, associated outcomes.Secondary analysis a multicenter prospective cohort (EU-VAP project).Twenty-seven European ICUs.Patients who were mechanically ventilated for greater than or equal to 48 hours. compared middle-aged (45-64 yr; n = 670), old (65-74 549), very patients (≥ 75 n=...
We utilized the database of Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion intermittent-bolus dosing piperacillin/tazobactam meropenem critically ill using inclusion criteria similar those used previous prospective studies. This was a post hoc analysis prospective, multicentre pharmacokinetic point-prevalence (DALI), which recruited large cohort from 68 ICUs...
Abstract Introduction The objective of the study was to describe pharmacokinetics (PK) fluconazole, anidulafungin, and caspofungin in critically ill patients compare with previously published data. We also sought determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets this cohort intensive care unit patients. Methods Defining Antibiotic Levels Intensive (DALI) a prospective, multicenter point-prevalence PK study. Sixty-eight units across Europe...
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...
The objectives of this study were to investigate the incidence candidemia, as well factors associated with Candida species distribution and fluconazole resistance, among patients admitted intensive care unit (ICU) during COVID-19 pandemic, compared two pre-pandemic periods. All ICU due from March 2020 October 2021, periods (2005-2008 2012-2015), who developed included. During period, candidemia was 10.2%, significantly higher 3.2% 4.2% in periods, respectively. proportion non-albicans...
The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and conditions; however, data have suggested that patterns of these differ between other pneumonitides. This secondary analysis aimed explore co-infection intensive unit-acquired infections (ICU-AI) the relationship use corticosteroids in large, international cohort critically ill patients.
Abstract Introduction Since positive blood cultures are uncommon in patients with nosocomial pneumonia (NP), the responsible pathogens usually isolated from respiratory samples. Studies on bacteremia associated hospital-acquired (HAP) have reported fatality rates of up to 50%. The purpose study is compare risk factors, and outcomes between bacteremic (B-NP) nonbacteremic (NB-NP) episodes. Methods This a prospective, observational multicenter (27 intensive care units nine European countries)....
Abstract Introduction The objective of this study was to describe the pharmacokinetics vancomycin in ICU patients and examine whether contemporary antibiotic dosing results concentrations that have been associated with favourable response. Methods Defining Antibiotic Levels Intensive Care (DALI) a prospective, multicentre pharmacokinetic point-prevalence study. as per treating clinician either by intermittent bolus or continuous infusion. Target trough concentration defined ≥15 mg/L target...