Sanjoy K. Paul
A5075417158- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Health and Mental Health
- Pharmacology and Obesity Treatment
- Diabetes Management and Education
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Health and Risk Factors
- Diabetes and associated disorders
- Diet and metabolism studies
- Antibiotic Use and Resistance
- Pancreatic function and diabetes
- Statistical Methods in Clinical Trials
- Bariatric Surgery and Outcomes
- Heart Failure Treatment and Management
- Health Promotion and Cardiovascular Prevention
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
- Obesity and Health Practices
- Potassium and Related Disorders
Melbourne Health
2017-2024
The University of Melbourne
2016-2024
The Royal Melbourne Hospital
2016-2023
Victoria Park
2022
AstraZeneca (United Kingdom)
2022
RMIT University
2021
Australian and New Zealand Intensive Care Society
2020
Epicentre (South Africa)
2019
QIMR Berghofer Medical Research Institute
2013-2018
Royal Brisbane and Women's Hospital
2016
During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of microvascular complications than did those receiving conventional dietary therapy. We conducted post-trial monitoring to determine whether this improved control persisted and such long-term effect on macrovascular outcomes.Of 5102 newly diagnosed diabetes, 4209 were randomly assigned receive either (dietary restriction) or (either...
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in achieves concentrations associated maximal activity affect patient outcome.This was prospective, multinational pharmacokinetic point-prevalence study including 8 antibiotics. Two blood samples were taken from each during single interval. The primary pharmacokinetic/pharmacodynamic targets free above the minimum inhibitory...
Post-trial monitoring of patients in the United Kingdom Prospective Diabetes Study (UKPDS) examined whether risk reductions for microvascular and macrovascular disease, achieved with use improved blood-pressure control during trial, would be sustained.Among 5102 UKPDS newly diagnosed type 2 diabetes mellitus, we randomly assigned, over a 4-year period beginning 1987, 1148 hypertension to tight or less-tight regimens. The 884 who underwent post-trial were asked attend annual clinics first 5...
Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control suboptimal, though evidence supporting specific regimens limited.In an open-label, controlled, multicenter trial, we randomly assigned 708 patients with a suboptimal glycated hemoglobin level (7.0 10.0%) who were receiving maximally tolerated doses of metformin and sulfonylurea receive biphasic aspart twice daily, prandial three times or basal detemir once daily (twice if required). Outcome measures...
Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited.In this 3-year open-label, multicenter trial, we evaluated 708 who had suboptimal glycated hemoglobin levels while taking metformin and sulfonylurea therapy. Patients were randomly assigned receive biphasic aspart twice daily, prandial three times or basal detemir once daily (twice if required). Sulfonylurea was replaced by a second hyperglycemia became...
In animals, immunomodulatory dendritic cells (DCs) exposed to autoantigen can suppress experimental arthritis in an antigen-specific manner. rheumatoid (RA), disease-specific anti-citrullinated peptide autoantibodies (ACPA or anti-CCP) are found the serum of about 70% RA patients and strongly associated with HLA-DRB1 risk alleles. This study aimed explore safety biological clinical effects autologous DCs modified a nuclear factor κB (NF-κB) inhibitor four citrullinated antigens, designated...
OBJECTIVE Hypoglycemia has been associated with an increased risk of cardiovascular (CV) events and all-cause mortality. This study assessed whether, in a nationally representative population, there is association between hypoglycemia, the CV events, mortality among insulin-treated people type 1 diabetes or 2 diabetes. RESEARCH DESIGN AND METHODS retrospective cohort used data from Clinical Practice Research Datalink database included all patients (≥30 years age) diagnosis RESULTS In who...
The aim of the study was to evaluate effect delay in treatment intensification (IT; clinical inertia) conjunction with glycaemic burden on risk macrovascular events (CVE) type 2 diabetes (T2DM) patients. A retrospective cohort carried out using United Kingdom Clinical Practice Research Datalink, including T2DM patients diagnosed from 1990 follow-up data available until 2012. In 105,477 mean HbA1c 8.1% (65 mmol/mol) at diagnosis, 11% had a history cardiovascular disease, and 7.1% experienced...
Aim To investigate whether clinical inertia, the failure to intensify treatment regimens when required, exists in people with type 2 diabetes treated basal insulin. Methods This was a retrospective cohort study involving patients UK Clinical Practice Research Datalink database between January 2004 and December 2011, follow-up until 2013. Results A total of 11 696 were included analysis. Among all patients, 36.5% had their intensified during period; these, 50.0, 42.5 7.4% bolus or premix...
Continuous infusion of β-lactam antibiotics may improve outcomes because time-dependent antibacterial activity compared with intermittent dosing.To evaluate the efficacy continuous versus in patients severe sepsis.We conducted a randomized controlled trial 25 intensive care units (ICUs). Participants commenced on piperacillin-tazobactam, ticarcillin-clavulanate, or meropenem were to receive prescribed antibiotic via 30-minute for remainder treatment course until ICU discharge. The primary...
To explore temporal trends in antidiabetes drug (ADD) prescribing and intensification patterns, along with glycemic levels comorbidities, possible benefits of novel ADDs delaying the need for insulin initiation patients diagnosed type 2 diabetes.Patients diabetes aged 18-80 years, who initiated any ADD, were selected (n = 1,023,340) from U.S. Centricity Electronic Medical Records. Those second-line ADD after first-line metformin identified (subcohort 1, n 357,482); third-line therapy choices...
Abstract Background The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability RRT techniques and antibiotic relate observed trough concentrations to targets. Methods We performed a prospective, observational, multinational, pharmacokinetic study 29 intensive care units from 14 countries. collected demographic, clinical, data. measured meropenem, piperacillin-tazobactam, vancomycin related...
Background Treatment of diabetes mellitus with Traditional Chinese Medicine has a long history. The aim this study is to establish the safety and efficacy traditional medicine combined glibenclamide treat type 2 mellitus. Methods In controlled, double blind, multicentre non-inferiority trial, 800 patients unsatisfactory glycemic control (fasting glucose 7–13 mmol/L HbA1c 7–11%) were randomly assigned receive Xiaoke Pill, compound herbs glibenclamide, or Glibenclamide in two groups – drug...
Gram-negative bacteria such as Escherichia coli or Klebsiella spp. frequently cause bloodstream infections. There has been a worldwide increase in resistance these species to antibiotics third generation cephalosporins, largely driven by the acquisition of extended-spectrum beta-lactamase plasmid-mediated AmpC enzymes. Carbapenems have considered most effective therapy for serious infections caused resistant bacteria; however, increased use creates selection pressure carbapenem resistance,...
The aim of this study was to evaluate the temporal pattern amputations in patients with type 2 diabetes mellitus (T2DM), risk by new and older anti-diabetic drugs (ADDs), interplay peripheral artery disease (PAD) therapy amputation risk.Using Centricity Electronic Medical Records from USA, 3 293 983 T2DM were identified: 169 739 received sodium-glucose cotransporter type-2 inhibitors (SGLT-2i; no exposure incretins); 149 826 glucagon-like peptide 1 receptor agonists [GLP-1RA, SGLT-2i or...
<h3>Aims:</h3> To evaluate the effect of a disease management programme for patients with coronary heart (CHD) and chronic failure (CHF) in primary care. <h3>Methods:</h3> A cluster randomised controlled trial 1316 CHD CHF from 20 care practices UK was carried out. Care intervention delivered by specialist nurses trained CHF. Usual healthcare team control practices. <h3>Results:</h3> At follow up, significantly more history myocardial infarction group were prescribed beta-blocker compared to...