A5035379938- Diabetes Treatment and Management
- Respiratory viral infections research
- Schizophrenia research and treatment
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Diet and metabolism studies
- Mental Health and Psychiatry
- Cardiac, Anesthesia and Surgical Outcomes
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 detection and testing
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Assays
- Mental Health Treatment and Access
- Gastrointestinal motility and disorders
- Folate and B Vitamins Research
- Cardiovascular Function and Risk Factors
- Family and Patient Care in Intensive Care Units
- Cardiac and Coronary Surgery Techniques
- Pharmacology and Obesity Treatment
- Lymphoma Diagnosis and Treatment
- Retinal Imaging and Analysis
- Cultural Competency in Health Care
University of Southampton
2020-2025
GlaxoSmithKline (India)
2024
Regeneron (United States)
2024
Cayman Chemical (United States)
2024
GlaxoSmithKline (Germany)
2024
AstraZeneca (Brazil)
2024
Novartis (Switzerland)
2024
Boehringer Ingelheim (China)
2024
Sanofi (France)
2024
GlaxoSmithKline (China)
2024
Not all patients with type 2 diabetes develop renal dysfunction. Identifying those at risk is problematic because even microalbuminuria, often used clinically as an indicator of future dysfunction, does not always precede worsening function. We sought to identify clinical factors diagnosis associated later development Of 5,102 U.K. Prospective Diabetes Study (UKPDS) participants, prospective analyses were undertaken in without albuminuria (n = 4,031) or normal plasma creatinine (n=5,032)...
Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control suboptimal, though evidence supporting specific regimens limited.In an open-label, controlled, multicenter trial, we randomly assigned 708 patients with a suboptimal glycated hemoglobin level (7.0 10.0%) who were receiving maximally tolerated doses of metformin and sulfonylurea receive biphasic aspart twice daily, prandial three times or basal detemir once daily (twice if required). Outcome measures...
Abstract Objectives AGILE is a Phase Ib/IIa platform for rapidly evaluating COVID-19 treatments. In this trial (NCT04746183) we evaluated the safety and optimal dose of molnupiravir in participants with early symptomatic infection. Methods We undertook dose-escalating, open-label, randomized-controlled (standard-of-care) Bayesian adaptive I at Royal Liverpool Broadgreen Clinical Research Facility. Participants (adult outpatients PCR-confirmed SARS-CoV-2 infection within 5 days symptom onset)...
To investigate the feasibility and acceptability of using liraglutide 3.0 mg daily in management overweight obesity people with schizophrenia, schizoaffective disorder first episode psychosis.A double-blind, randomized, placebo-controlled pilot trial took place mental health centres primary care within Southern Health NHS Foundation Trust. The participants were adults or first-episode psychosis prescribed antipsychotic medication who obese. intervention was once-daily subcutaneous placebo,...
Abstract Background People with severe mental illness (SMI) are two to three times more likely be overweight and obese than the general population this is associated significant morbidity premature mortality. Although lifestyle interventions can support people SMI lose weight, some unable make necessary changes or, despite making changes, continue gain weight. Objective To assess feasibility acceptability of delivering a full-scale trial evaluating whether liraglutide 3.0 mg, once-daily...
Background Respiratory viral infections (RVIs) are a significant cause of morbidity and hospital admission worldwide. However, the management most infection-associated diseases remains primarily supportive. The recent COVID-19 pandemic has underscored urgent need for deeper understanding RVIs to improve patient outcomes develop effective treatment strategies. Understanding Infection, Viral Exacerbation Symptoms at Admission-Longitudinal Study is an observational study which addresses this by...
The aim of this study was to inform thinking around the terminology for 'schizophrenia' in different countries.The objective investigate: (1) whether medical students view alternative (psychosis subgroups), derived from vulnerability-stress models schizophrenia, as acceptable and less stigmatising than term schizophrenia; (2) if there are differences attitudes across countries with cultures (3) clinical training has an impact reducing stigma.This is a cross-sectional survey that examined...
Background: Although many acute exacerbations of COPD (AECOPD) are triggered by non-bacterial causes, they often treated with antibiotics. Preliminary research suggests that the Chinese herbal medicine "Shufeng Jiedu" (SFJD), may improve recovery and therefore reduce antibiotic use in patients AECOPD. Aims: To assess feasibility conducting a randomised placebo-controlled clinical trial SFJD for AECOPD UK primary care. Methods: GPs opportunistically recruited experiencing an Participants were...
Introduction Cardiothoracic surgical outcomes are poorer in people with diabetes compared those without diabetes. There two important uncertainties the management of undergoing major surgery: (1) how to improve weeks leading up an elective procedure and (2) whether that improved leads better postoperative outcomes. We previously demonstrated feasibility delivering Optimising Cardiac Surgery ouTcOmes People diabeteS (OCTOPuS) intervention, outpatient intervention delivered by healthcare...
Abstract Background AGILE is a phase Ib/IIa platform for rapidly evaluating COVID-19 treatments. In this trial ( NCT04746183 ) we evaluated the safety and optimal dose of molnupiravir in participants with early symptomatic infection. Methods We undertook dose-escalating, open-label, randomised-controlled (standard-of-care) Bayesian adaptive I at Royal Liverpool Broadgreen Clinical Research Facility. Participants (adult outpatients PCR-confirmed SARS-CoV-2 infection within 5 days symptom...
Objectives To evaluate whether a newly developed care pathway, Treatment and Recovery In PsycHosis (TRIumPH), is feasible, acceptable effective in meeting National Institute of Health Care Excellence (NICE) quality standards timely manner. Methods This pragmatic, non-randomised, prospective, mixed methods study comparing an implementation (TRIumPH) comparator site (not implementing TRIumPH) across three cohorts to assess feasibility, acceptability effectiveness the integrated pathway....
To determine current practice regarding the diabetes management of people undergoing cardiac surgery in UK.We conducted an online survey UK cardiothoracic surgeons. All surgeons listed Society Cardiothoracic Surgery membership directory were invited to participate. The survey, compiled using SurveyMonkey software, comprised 15 closed and open-ended questions about with pre- peri-operatively.Sixty-two from all 33 centres completed survey. Of these, 44% responded that they routinely measure...
Cardiothoracic surgical outcomes are poorer in people with diabetes compared those without diabetes. There two important uncertainties the management of undergoing major surgery: (1) how to improve weeks leading up an elective procedure and (2) whether that improved leads postoperative outcomes. The aim this study was develop pilot a specialist team-led intervention Open feasibility SETTING: Diabetes cardiothoracic surgery departments, University Hospital Southampton NHS Foundation Trust...
Abstract Background Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major reason for consultations in primary care, hospital admissions, deterioration function, and mortality. Despite the majority not being caused by bacteria, as many 70% patients who present UK care with AECOPD prescribed antibiotics part standard care. However, finding effective non-antibiotic treatments COPD is priority to reduce antibiotic use. The Chinese herbal medicine Shufeng Jiedu® (SFJD)...
Culture influences models of mental illness, help-seeking behaviours and outcomes interventions. Cultural competency training has been developed to improve clinician practice in addressing these issues. The study aims identify what extent culturally competent informed interactions are used by clinicians England how patients experience interaction. Clinicians non-white western were recruited complete a questionnaire on adapted 25 areas England. much more likely rate their as clinically...