A5038922000- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Allergic Rhinitis and Sensitization
- Pulmonary Hypertension Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Influenza Virus Research Studies
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- HIV/AIDS Research and Interventions
- Neonatal Respiratory Health Research
- Exercise and Physiological Responses
University Hospital Southampton NHS Foundation Trust
2018-2025
University of Southampton
2018-2025
NIHR Southampton Biomedical Research Centre
2019-2025
National Institute for Health Research
2020-2024
Southampton General Hospital
2013-2024
Quest University Canada
2023
National Health Service
2023
NIHR Southampton Respiratory Biomedical Research Unit
2021-2023
King's College London
2010-2014
Asthma UK
2011-2014
Abstract Background The COVID-19 pandemic has led to more than 760,000 deaths worldwide (correct as of 16th August 2020). Studies suggest a hyperinflammatory response is major cause disease severity and death. Identitfying patients with hyperinflammation may identify subgroups who could benefit from targeted immunomodulatory treatments. Analysis cytokine levels at the point diagnosis SARS-CoV-2 infection can risk deterioration. Methods We used multiplex assay measure serum IL-6, IL-8, TNF,...
Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma chronic obstructive pulmonary disease (COPD). IFN-β is a key component the innate immune response to viral infection. To date, studies inhaled treatment have not demonstrated significant effect on exacerbations.Objectives: The dynamics exogenous activity were investigated inform future indications for this potential antiviral therapy.Methods: Monocyte-derived macrophages (MDMs),...
Abstract Background Blood eosinophil measurement is essential for the phenotypic characterization of patients with difficult asthma and in determining eligibility anti‐IL‐5/IL‐5Rα biological therapies. However, assessing such measures over limited time spans may not reveal true underlying eosinophilic phenotype, as treatment, including daily oral corticosteroid therapy, suppresses inflammation intrinsically variable. Methods We interrogated electronic healthcare records Wessex AsThma CoHort...
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, caused emphysema and small airways (SAD). Computed tomography (CT) coupled with image analysis enables the quantification of these abnormalities; however, optimum method for doing so has not been determined.Objectives: This study aims to compare two CT quantitative techniques, probability measure (DPM) parametric response mapping (PRM), assess their relationship specific physiological measures...
Omalizumab and Mepolizumab are biologic drugs with proven efficacy in clinical trials. However, a better understanding of their real-world effectiveness severe asthma management is needed.To understand the Mepolizumab, elucidate phenotypes patients treated these drugs, identify baseline characteristics associated response assess spectrum responses to medications.Using data, we retrospectively phenotyped naïve from Wessex AsThma CoHort difficult (N = 478) commenced on 105) or 62) compared not...
Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of number biological targets and development various novel therapies. Despite this, asthma still represents significant health economic burden worldwide. Why some individuals should continue suffer remains unclear. Wessex Cohort Difficult (WATCH) an ongoing 'real-life', prospective study patients in University Hospital Southampton Foundation Trust (UHSFT) service. Research data...
Abstract Background Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus (COVID-19). Early data suggest elevated Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) receptor angiotensin converting enzyme (ACE2) expression, but relationships to phenotype and downstream regulators inflammation in the Renin-Angiotensin system (RAS) unknown. We aimed determine relationship between RAS gene expression relevant SARS-CoV-2 infection lung with...
Abstract Background The long-term consequences of COVID-19 remain unclear. There is concern a proportion patients will progress to develop pulmonary fibrosis. We aimed assess the temporal change in CXR infiltrates cohort following hospitalisation for COVID-19. Methods conducted single-centre prospective study admitted University Hospital Southampton with confirmed SARS-CoV2 infection between 20th March and 3rd June 2020. Patients were approached standard-of-care follow-up 12-weeks after...
BackgroundAsthma is conventionally stratified as type 2 inflammation (T2)-high or T2-low disease. Identifying T2 status has therapeutic implications for patient management, but a real-world understanding of this paradigm in difficult-to-treat and severe asthma remains limited.ObjectivesTo identify the prevalence T2-high patients using multicomponent definition compare clinical pathophysiologic characteristics between classified T2-low.MethodsWe evaluated 388 biologic-naive from Wessex Asthma...
Abstract Background Exercise is recommended in guidelines for asthma management and has beneficial effects on symptom control, inflammation lung function patients with sub-optimally controlled asthma. Despite this, physical activity levels difficult are often impaired. Understanding the barriers to exercise people crucial increasing their activity, implementing successful, disease modifying, holistic approaches improve health. Methods 62 Patients within WATCH Difficult Asthma Cohort...
Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory antipathogenic functions. Previous studies demonstrated dysregulation of some individual components in COPD. We investigated relationships between COPD disease measures gain new insights into potential mechanisms.Bronchoalveolar lavage proteome lipidome were characterised ex-smoking mild/moderate subjects (n=26) healthy (n=20) never-smoking...
Background. Very little is known about older adults accessing HIV care in sub-Saharan Africa. Materials and Methods. Data were obtained from 18,839 HIV-positive at 10 treatment programs Burundi, Cameroon, the Democratic Republic of Congo. We compared characteristics those aged 50+ with 18-49 using chi-square tests. Logistic regression was used to determine if age associated medication adherence. Results. 15% years. Those more evenly distributed between women men (56% versus 44%) as (71% 29%)...
Difficult asthma describes in which comorbidities, inadequate treatment, suboptimal inhaler technique and/or poor adherence impede good control. The association of anxiety and depression with difficult outcomes (exacerbations, hospital admissions, control, etc.) is unclear. This study assessed the clinical associations patients a specialist diagnosis asthma. Using real-world data, we retrospectively phenotyped from Wessex Asthma Cohort (N = 441) using diagnoses against those without or...
Redox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms reduce inflammation patients, but the underlying mechanisms remain unclear. We hypothesized that a personalised exercise intervention would control by reducing lung through modulation of local systemic reactive species interactions, thereby increasing antioxidant capacity. combined deep redox metabolomic profiling with clinical assessment an exploratory cohort six...
<h3>Abstract</h3> <b>Objective</b> To establish whether acutely unwell patients admitted to hospital wish participate in discussions about resuscitation. <b>Design</b> Prospective, cross sectional study of a successive cohort patients. <b>Setting</b> Admission through the emergency department. <b>Participants</b> 374 adult <b>Main outcome measure</b> Whether wished <b>Results</b> Of total sample, 74 consented take part and provide full data. remaining patients, 189 could not be approached...