A5037135286- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Luminescence and Fluorescent Materials
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- Molecular Sensors and Ion Detection
- Digestive system and related health
- Cancer, Lipids, and Metabolism
- S100 Proteins and Annexins
- Advanced Fiber Optic Sensors
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
Xiamen University
2025
Kunming Children's Hospital
2021-2025
Second Affiliated Hospital of Harbin Medical University
2015-2024
Harbin Medical University
2015-2024
Jilin University
2008-2024
Donghua University
2024
Jilin Province Science and Technology Department
2024
Ningxia Medical University
2024
West China Medical Center of Sichuan University
2024
University of Calgary
2008-2023
MS4A4A is a member of the membrane‐spanning, four domain family, subfamily A (MS4A) that includes CD20 (MS4A1), FcRβ (MS4A2) and Htm4 (MS4A3). Like first three members this transcription appears to be limited hematopoietic cells. To evaluate expression protein in cell lineages subsets we generated monoclonal antibodies against extracellular epitopes for use flow cytometry. In human peripheral blood found expressed at plasma membrane monocytes but not granulocytes or lymphocytes. vitro...
Increasing evidence has shown that cancer stem cells or tumor initiating are the 'root cause' of malignant cancers. However, exact origin still remains obscure in thyroid research. EMT been implicated initiation and conversion early-stage tumors into invasive malignancies is associated with stemness cells. Based on these facts, a new hypothesis was suggested induces cell generation progression human vitro. In present study, FTC133 identified as EMT-negative were used for induction by HIF‑1α...
Abstract Previous studies indicated that circular RNAs (circRNA) played vital roles in the development of non–small cell lung cancer (NSCLC). Although hsa_circ_0014130 might be a potential NSCLC biomarker, its function remains unknown. Thus, this study aimed to investigate role progression NSCLC. The levels tissues and adjacent normal were determined by qRT-PCR. In addition, expressions Bcl-2 cleaved caspase-3 A549 cells detected with Western blot analysis. Meanwhile, dual luciferase...
Abstract Homogeneous crosslinked networks can achieve a balance between the strength and toughness of various biological materials, yet continuous synthesis such remains challenging. Here, strategy involving microcrystal dispersed growth to continuously fabricate hydrogel fibers with homogeneous network through wet spinning is reported. Rapid phase separation induced by solvent exchange under dense entanglement results in uniform microcrystalline network. Salting‐out crystal within densified...
The MS4A gene family in humans includes CD20 and at least 15 other genes. exists as homo-oligomers the plasma membrane, however different proteins expressed same cell may hetero-oligomerize. Given importance of B-cell function a therapeutic target, we sought to explore potential for hetero-oligomerization with proteins. We investigated expression primary human B-cells four genes previously shown be lines (MS4A4A, MS4A6A, MS4A7, MS4A8B), well two comprising closely related TMEM176 family,...
Abstract Background Glioblastoma (GBM) is the most aggressive malignant central nervous system tumor with a poor prognosis.The transformation of glioma cells via epithelial-mesenchymal transition (EMT) has been observed as main obstacle for glioblastoma treatment. Epithelial membrane protein 3 ( EMP3 ) significantly associated malignancy GBM and prognosis patients. Therefore, exploring possible mechanisms by which promotes growth important implications treatment GBM. Methods We performed...
Constructing heterojunction photocatalysts are widely applied to boost the photocatalytic activity of materials. Here, a novel covalent organic framework (COF) material with heptazine units was developed and hybridized TiO
This study was designed to detect miR‐575 expression and function in non‐small cell lung cancer (NSCLC). A higher of NSCLC tissues observed compared with adjacent non‐neoplastic tissues. Furthermore, re‐introduction significantly promoted proliferation, migration, invasion the line. Moreover, we showed that BLID is negatively regulated by at posttranscriptional level, via a specific target site within 3′UTR. Overexpression counteracted miR‐575‐induced proliferation cells. The frequently...
Tumor metastasis profoundly reduces the survival of breast cancer patients, but mechanisms underlying invasiveness and are incompletely understood. Here, we report that E3 ubiquitin ligase Smurf2 acts in a sumoylation-dependent manner to suppress invasive behavior MDA-MB-231 human cell-derived organoids. We also find SUMO PIAS3 inhibits growth In mechanistic studies, maintains organoids non-invasive state via sumoylation Smurf2. Importantly, activity is required for sumoylated cancer-cell...
Metastasis is the ultimate cause of breast cancer related mortality. Epithelial-mesenchymal transition (EMT) thought to play a crucial role in metastatic potential cancer. Growing evidence has implicated SUMO E3 ligase PIAS1 regulation EMT mammary epithelial cells and metastasis. However, relevance human mechanisms by which might regulate metastasis remain be elucidated. Using tissue-microarray analysis (TMA), we report that protein abundance subcellular localization correlate with disease...
Metastasis is the major cause of cancer-related morbidity and mortality. The ability cancer cells to become invasive migratory contribute significantly metastatic growth, which necessitates identification novel anti-migratory anti-invasive therapeutic approaches. Proteoglycan 4 (PRG4), a mucin-like glycoprotein, contributes joint synovial homeostasis through its friction-reducing anti-adhesive properties. Adhesion surrounding extracellular matrix (ECM) components critical for invade ECM...
Epithelial-mesenchymal transition (EMT) is critical for carcinoma invasiveness and metastasis. To investigate the role of membrane-type-2 matrix metalloproteinase (MT2-MMP) in EMT, we generated lentiviral constructs wild-type (WT) an inactive Glu260Ala (E260A) mutant MT2-MMP derived stably transfected HCT116 A549 cell lines. WT-transfected cells appeared mesenchymal-like, whereas with E260A were epithelial-like, as treated MMP inhibitor (GM6001). Expression E-cadherin, β-catenin, zonula...
Extraction of micro-vibration information from a single-shot speckle image is realized base on the row-by-row exposure mechanism rolling shutter camera and high intensity laser speckle. Normalized cross correlation cubic spline interpolation algorithm firstly used between nonoverlapping gray scales adjacent rows to infer micro-displacement information. With number set as 342, wide frequency range 300 Hz 20 kHz sinusoid signals are recovered with relative errors smaller than 2%. For low 40...
Pulmonary sequestration (PS) is a rare congenital lung developmental anomaly characterized by abnormal tissue that receives its blood supply from the aorta. Among various types, mixed PSrepresents distinct subtype. Currently, there lack of definitive reports regarding specific management this condition in infants and young children. We report case 1-year-old patient with PS treated endovascular occlusion under digital subtraction angiography (DSA). Given patient's age complexity vascular...
Objective Coronary artery lesions (CAL) represent the most severe complication of Kawasaki disease (KD). Currently, there is no standardized method for predicting CAL in KD, and predictive effectiveness varies among different KD patients. Therefore, our study aims to establish distinct models complications based on characteristics clusters. Methods We employed principal component clustering analysis categorize 1,795 patients into clustered subgroups. summarized each cluster compared...
Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with a significant global burden. This study evaluates global, regional, and national trends in prevalence, mortality, disability-adjusted life years (DALYs) of childhood ALL from 1990 to 2021, providing insights into disparities progress across different socio-demographic geographic contexts. Methods Data were sourced Global Burden Disease study. Trends DALYs analyzed by index (SDI) regions, areas, countries....
Background Previous estimates of congenital heart disease (CHD) have been constrained by limited data sources, narrow geographic focus, and a lack specific assessment infants younger than 1 year. As part the Global Burden Diseases (GBD), Injuries, Risk Factors Study 2021, this research provides comprehensive mortality, prevalence, disability attributable to CHD in under The study encompasses from 204 countries territories, covering period 1990 2021. Methods This cross-sectional analysis...
Kawasaki disease is an acute immune vasculitis that often has a poor prognosis when complicated by coronary artery lesions. Our study aims to construct risk model for lesions and validate it in different clinical characteristic subgroups, optimizing personalized precise management of improve patient outcomes. First, we compared each factor between the groups with without damage. We then used LASSO analysis further filter factors were more significant predicting The selected model. was...
Turner syndrome (TS), a chromosomal disorder (45, X) affecting approximately 1 in 2,000 female births, results multisystem morbidity. This study aims to report global trends the prevalence and disability-adjusted life years (DALYs) of childhood TS from 1990 2021. analyzed DALYs children aged 0-14 using data Global Burden Disease (GBD) database. Prevalence were calculated per 100,000 population with 95% uncertainty intervals (UI). A log-transformed linear regression model was applied estimate...