A5100373339- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- IL-33, ST2, and ILC Pathways
- Lung Cancer Treatments and Mutations
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Pregnancy and preeclampsia studies
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Diabetic Foot Ulcer Assessment and Management
- Autoimmune and Inflammatory Disorders Research
- Animal Virus Infections Studies
- Ovarian function and disorders
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA Interference and Gene Delivery
- Microplastics and Plastic Pollution
- SARS-CoV-2 detection and testing
- Herpesvirus Infections and Treatments
- Coronary Artery Anomalies
Kunming Children's Hospital
2022-2025
China Medical University
2023-2024
Jinzhou Medical University
2011-2024
Logistics University of People's Armed Police Force
2024
Chinese People's Armed Police Force
2024
Weatherford College
2024
Affiliated Hospital of Qingdao University
2007-2023
Xiaomi (China)
2023
Qingdao University
2007-2023
First Affiliated Hospital of Xinxiang Medical University
2019-2023
A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and coordination complex zinc metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes healing traumatic skin defect burn injury promoting cell proliferation, angiogenesis, collagen formation. Furthermore, find ZnMet could inhibit reactive oxygen species (ROS) production through activation autophagy, thereby protecting from oxidative stress induced...
Abstract Background Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties and simultaneously lack the ability to illicit immune responses. Hence, MSCs have emerged as a promising candidate for cellular therapeutics inflammatory diseases. Within context of this study, we investigated whether human umbilical cord-derived mesenchymal (UC-MSCs) could ameliorate lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in rat model. Methods ALI was via injection LPS. Rats were...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people globally. Virus infection requires the receptor-binding domain (RBD) spike protein. Although studies have demonstrated anti-spike and -RBD antibodies to be protective in animal models, convalescent plasma as a promising therapeutic option, little is known about immunoglobulin isotypes capable blocking infection.We studied spike- RBD-specific plasma/serum samples using multiplex bead assay. We also...
Abstract SARS-CoV-2 has infected millions of people and is on a trajectory to kill more than one million globally. Virus entry depends the receptor-binding domain (RBD) spike protein. Although previous studies demonstrated anti-spike –RBD antibodies as essential for protection convalescent plasma promising therapeutic option, little known about immunoglobulin (Ig) isotypes capable blocking virus entry. Here, we studied spike- RBD-specific Ig in plasma/sera from two acutely 29 individuals....
Autophagy is a common biological phenomenon in eukaryotes that has evolved and reshaped to maintain cellular homeostasis. Under the pressure of starvation, hypoxia, immune damage, autophagy provides energy nutrients cells, which benefits cell survival. In mammals, an early embryonic nutrient supply system involved development, implantation, pregnancy maintenance. Recent studies have found imbalance placental tissue plays key role occurrence development complications, such as gestational...
Tri-ortho-cresyl phosphate (TOCP) has been widely used as plasticizers, plastic softeners, and flame retardants in industry reported to have a deleterious effect on the male reproductive system animals besides delayed neurotoxicity. Our preliminary results found that TOCP could disrupt seminiferous epithelium testis inhibit spermatogenesis, but precise mechanism is yet be elucidated. This study shows inhibited viability of rat spermatogonial stem cells dose-dependent manner. not lead cell...
As a plasticizer, plastic softener, and flame-retardant, tri-ortho-cresyl phosphate (TOCP) is has been widely used in industry reported to have toxic effect on the male reproductive system animals besides neurotoxicity immunotoxicity. We that TOCP inhibits spermatogenesis induces autophagy of rat spermatogonial stem cells, but it still unknown whether mouse Leydig cells its potential mechanism.Cell viability was observed by MTT assay. Level testosterone measured radioimmunoassay. Apoptosis...
UV-induced photodegradation posed greater cytotoxicity, as clearly evidenced by the impaired cell viability, stronger oxidative stress, serious membrane damage, intensive mitochondrial dysfunction, and altered transcriptome responses.
Antibodies (Abs) are essential for the host immune response against SARS-CoV-2, and all vaccines developed so far have been designed to induce Abs targeting SARS-CoV-2 spike. Many studies examined Ab responses in blood from vaccinated infected individuals. However, since is a respiratory virus, it also critical understand mucosal at sites of initial virus exposure. Here, we plasma versus saliva convalescent patients. Although levels were significantly lower, strong correlation was observed...
The obesity-asthma phenotype is characterized by increased asthma severity and decreased glucocorticoid responsiveness. To date, the mechanism underlying association between obesity remain to be fully elucidated. present study investigated correlation oxidative stress nuclear factor (NF)-κB pathway in obese asthmatic mice. animals were divided into following groups: Control (n=8), comprising C57BL/6J mice without exposure a high-fat diet; non-obese group of normal weight subjected induction...
Kawasaki disease is an acute immune vasculitis that often has a poor prognosis when complicated by coronary artery lesions. Our study aims to construct risk model for lesions and validate it in different clinical characteristic subgroups, optimizing personalized precise management of improve patient outcomes. First, we compared each factor between the groups with without damage. We then used LASSO analysis further filter factors were more significant predicting The selected model. was...
Cystic fibrosis (CF) is caused by CFTR gene mutations. Its diagnosis mainly depends on genetic and sweat chloride tests, but the complexity of these mutations challenges diagnosis. This paper reports a new case Chinese child with cough wheezing, suspected having CF. Trio whole-exome sequencing for pedigree was carried out to detect Five tools, namely Mutation Taster, PolyPhen-2, SIFT, FATHMM, PROVEAN, were used predict impacts protein function. AlphaFold employed structures, GROMACS software...
Objective This study aimed to implement shared medical appointment multidisciplinary interventions for non-organic feeding disorders in infants and young children evaluate their effects. Methods A total of 52 aged 6–24 months respective feeders were included the study. Of them, 26 classified into intervention group, control group. Routine child health care measures applied The combined with interventions, including 3 collective follow-up, Data concerning physical growth indicators, Montreal...
Purpose: To investigate the antitumor activity and mechanism of chloroquine (CQ) in combination with cisplatin (DDP) nude mice xenografted gastric cancer SGC7901 cells.Materials Methods: 35 cases patients malignant ascites were enrolled intraperitoneal injection was performed.Ascites collected before 5 days after perfusion for assessment autophagy levels cells.In addition, 24 tumor-bearing randomly divided into control, DDP, CQ + DDP groups.Results: In 54.3% (19/35) treatment therapeutically...
Asthma is a serious chronic inflammatory disease affecting 300 million people worldwide. This aim of this study to investigate the anti-inflammatory and anti-asthmatic effects Laminaria japonica extract in ovalbumin (OVA)-induced mouse asthma model. A model was established SPF Kunming mice by OVA-sensitization followed inhalation aerosol allergen for two weeks. polysaccharides (LJPS) were given gavage feeding at 50 mg/kg/day during OVA challenge period, their effect on compared with standard...
Objective Although Kawasaki disease (KD) is commonly regarded as a single entity, clinical subgroups have recently been described. We aimed to validate previous research on and establish KD subgroup differentiation model specific China. Methods analysed data of 1682 patients diagnosed with at the Kunming Children’s Hospital from December 2014 2022. performed principal component analysis hierarchical clustering 13 continuous variables. Then, we grouped based optimal number clusters...
Asthma is a common chronic inflammatory respiratory disease characterised by airway inflammation and hyperresponsiveness. The present study was designed to clarify the effect of intranasal miR‑410 administration in an ovalbumin (OVA)‑induced murine model asthma. It found that expression significantly decreased lungs OVA‑induced asthmatic mice (P<0.05) overexpressed via instillation. Bioinformatics indicated 3'‑untranslated regions interleukin (IL)‑4 IL‑13 messenger RNAs (mRNAs) contain...
The purpose of this study was to analyze the growth status and identify risk factors that influence catch-up preterm infants after discharge provide evidence for feeding strategies need further research. A descriptive correlational analysis applied. sample consisted 309 their caregivers selected from June August 2017 five women's children's hospitals. Self-designed questionnaires based on knowledge, attitude practice Health Belief Model (HBM) were used measure discharge. Logistic regression...