A5083960636- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Liver physiology and pathology
- Viral gastroenteritis research and epidemiology
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Atrial Fibrillation Management and Outcomes
- Hepatitis C virus research
- HER2/EGFR in Cancer Research
- Cardiac Imaging and Diagnostics
- Hepatitis B Virus Studies
- Folate and B Vitamins Research
- Cancer-related gene regulation
- Reproductive Biology and Fertility
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
Capital Medical University
2010-2025
Chinese University of Hong Kong, Shenzhen
2023
University of Chinese Academy of Sciences
2023
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
University of Maryland, College Park
2023
Second Affiliated Hospital of Zhengzhou University
2023
Shanghai Public Health Clinical Center
2020-2022
Guangxi Medical University
2021
Shenyang Pharmaceutical University
2020
Chongqing Three Gorges Central Hospital
2020
Amplification of 1q is one the most frequent chromosomal alterations in human hepatocellular carcinoma (HCC). In this study we identified and characterized a novel oncogene, Maelstrom ( MAEL ), at 1q24. overexpression was frequently detected HCCs significantly associated with HCC recurrence P = 0.031) poor outcome 0.001). Functional demonstrated that promoted cell growth, migration, tumor formation nude mice, all which were effectively inhibited when silenced short hairpin RNA (shRNAs)....
To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC).In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240 mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3), or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue progression-free survival (PFS) as primary for 1/2.A...
HEV ORF2 antigen (Ag) in serum has become a tool for diagnosing current infection. Particularly, urinary shedding of Ag been gaining increasing interest. We aim to uncover the origin, antigenicity, diagnostic performance, and significance urine infection.Clinical samples from patients with acute chronic infection were analyzed their levels. was by biochemical proteomic approaches. The origin kinetics during investigated mouse rabbit models, respectively. found that both level sensitivity...
Reprogramming impairment of DNA methylation may be partly responsible for the low efficiency in somatic cell nuclear transfer. In this study, bovine fibroblast cells were transfected with enhancer green fluorescence protein (eGFP), and then treated a histone-deacetylase inhibitor, trichostatin A (TSA). The results showed that effect TSA on was dose dependent. When concentration over 5 ng/ml, proliferation significantly inhibited. majority died when reached 100 ng/ml (P < 0.01). number S...
Minimally invasive pulmonary vein isolation was developed as a treatment of lone atrial fibrillation. Until recently, electrophysiological studies in patients with recurrent arrhythmias had not been described.One hundred thirty underwent mini-maze isolation. We performed catheter ablation guided by CARTO mapping 8 (mean 61.8 + or - 12.7 years old; male:female ratio, 5:3) 5.0 14 months after the original surgical procedure.Recurrent fibrillation occurred 4 patients, tachycardia 1 patient, and...
Previous studies have presented conflicting results on the correlation between metabolic syndrome (MetS) and subclinical atherosclerosis. However, binary MetS definition cannot reflect severity of disorders continuously dynamically. The present study calculated score explored association A total 840 participants were included in this observational, cross-sectional study; 66.55% men, median age was 61.00 years (53.00, 67.00). Brachial-ankle pulse wave velocity (baPWV) brachial flow-mediated...
The pathogenicity of each hepatitis E virus (HEV) genotypes/subtypes may be different. This study aimed to investigate the infectivity and different HEV from mammalian sources especially human in rabbits, assess whether rabbits are an appropriate animal model genotypes/subtypes. Thirty-seven were randomly divided into nine groups inoculated with eight strains, including human-derived HEV3b (hHEV-3b), hHEV-4a, hHEV-4d hHEV-4h, swine-derived HEV4d (sHEV-4d) sHEV-4h, rabbit-derived HEV3...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that level BDNF in follicular fluid marker for oocyte quality and infertility. Here, we intend to further investigate function its signaling pathway regulation endometrial cells proliferation. We found critical cells. Activation signal transducer activator transcription 3 required BNDF-regulated cell Furthermore, an effector estrogen Finally, investigated different role...
<h3>Objective</h3> To determine the relationship of high-sensitive C-reactive protein (hsCRP) and efficacy safety dual antiplatelet therapy in patients with without intracranial arterial stenosis (ICAS) Clopidogrel High-Risk Patients Acute Non-disabling Cerebrovascular Events (CHANCE) trial. <h3>Methods</h3> A subgroup 807 both magnetic resonance angiography images hsCRP measurement was analyzed. Cox proportional hazards models were used to assess interaction levels effects single therapy....
We investigated the left atrial myocardial deformation in patients with primary aldosteronism using speckle-tracking echocardiographic (STE) strain imaging technique.Our study included 107 [52 aldosterone-producing adenoma (APA) and 55 idiopathic hyperaldosteronism (IHA)] 50 hypertensive patients. performed conventional echocardiography to measure volume ejection fraction, STE estimate including peak velocity, rate calculate ratio of E/e' during ventricular systole as stiffness...
ABSTRACT Due to a combination of asymptomatic or undiagnosed infections, the proportion United States population infected with SARS-CoV-2 was unclear from beginning pandemic. We previously established platform screen for positivity across representative US population, which we reported that almost 17 million Americans were estimated have had undocumented infections in Spring 2020. Since then, vaccine rollout and prevalence different variants further altered seropositivity trends within...
// Ze-Han Liu 1, * , Qi Zhang 2, 3, Yi-Jie Ding 4, Ying-Hui Ren 3 Hui-Peng Yang Qing Xi Ying-Nan Cheng Guo-Lin Miao Hong-Kun Cai-Xia Li 2 Wen-Qiang Yan 5 Zhenyi Xue Lijuan Xin-Ye 6 Chen-Long Zhao Yurong Da Xian-Zhong Wu Jun-Qiang Chen 7 Rongxin 8, and Zhi-Gang 9, 6, 1 Nankai Clinical College, Tianjin Medical University, Tianjin, P.R. China Institute of Integrative Medicine Therapy for Acute Abdominal Diseases Hospital, P. R. Laboratory Immunology Inflammation, Department Immunology, Key...
Epstein-Barr virus (EBV) infection is closely associated with nasopharyngeal carcinoma (NPC) and increases the chemotherapy resistance of tumor cells. Although mechanism by which EBV manipulates ataxia telangiectasia mutation (ATM)-mediated DNA damage response in NPC has been extensively studied, relationship between ATR (ATM Rad-3 related) largely unexplored, also role EBV-positive not specifically reported.Levels γ-H2AX, latent membrane protein 1 (LMP1), EBV-encoded RNA clinical...
Podoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of masses. Previous studies investigating association between PDPN expression patient prognosis have had contradictory results. In present study, it was hypothesized that different locations PDPN‑positive may explain these varying The study aimed to focus on esophageal cell nests. order analyze clinical significance this expression, immunohistochemistry performed...