A5076678939- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Peptidase Inhibition and Analysis
- Oral Health Pathology and Treatment
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- NF-κB Signaling Pathways
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Marine Sponges and Natural Products
- Lung Cancer Treatments and Mutations
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
State Key Laboratory of Oral Diseases
2014-2020
Sichuan University
2014-2020
National Institute on Aging
2018-2020
National Institutes of Health
2020
Washington University in St. Louis
2014
Article16 September 2020Open Access Source DataTransparent process Re-equilibration of imbalanced NAD metabolism ameliorates the impact telomere dysfunction Chongkui Sun Biomedical Research Center, National Institute on Aging/National Institutes Health, Baltimore, MD, USA Search for more papers by this author Kun Wang Amanda J Stock Yi Gong Tyler G Demarest Beimeng Yang Neelam Giri orcid.org/0000-0001-7353-1863 Clinical Genetics Branch, Division Cancer Epidemiology and Genetics, Institute,...
Background Human beta-defensin-1 (hBD-1) has recently been considered as a candidate tumor suppressor in renal and prostate cancer. The aim of this study was to investigate the role hBD-1 progression oral squamous cell carcinoma (OSCC) its potential diagnostic/prognostic biomarker therapeutic target for OSCC. Methods HBD-1 expression tissues at different stages carcinogenesis, well OSCC lines examined. overexpressed HSC-3, UM1, SCC-9 SCC-25 cells subjected growth, apoptosis, migration...
Summary In a previous whole exome sequencing of patients from 41 families with Hodgkin lymphoma, we identified two distinct heterozygous rare coding variants in POT 1 (D224N and Y36H), both highly conserved region the gene. D224N mutant did not bind to single‐stranded telomere oligonucleotide vitro suggesting mutation perturbs 1's ability telomeric G‐rich overhang. Human HT 1080 cells expressing lymphoblastoid carrying Y36H showed increased length fragility comparison wild type cells. This...
Abstract Chronic inflammation induced by persistent viruses infection plays an essential role in tumor progression, which influenced on the interaction between cells and microenvironment. Our earlier study showed that ATR, a key kinase participant single-stranded DNA damage response (DDR), was obviously activated Epstein–Barr virus (EBV) nasopharyngeal carcinoma (NPC). However, how EBV-induced ATR activation promotes NPC influencing inflammatory microenvironment, such as tumor-associated...
WRAP53, including α, β and γ isoforms, plays an important role not only in the stability of p53 mRNA, but also assembly trafficking telomerase holoenzyme. It has been considered oncogene is thought to promote survival cancer cells. The aim this study was detect TCAB1 (except WRAP53α) occurrence development head neck carcinomas.Immunohistochemistry used expression clinical specimen sections performed western blotting check levels cell lines. depleted using shRNA lentivirus knockdown...
// Chong-kui Sun 1,2,* , Fan Zhang 1,* Tao Xiang 1 Qianming Chen 2 Tej K. Pandita 3 Yuping Huang 4 Mickey C.T. Hu 5 and Qin Yang Cancer Biology Division, Department of Radiation Oncology, Washington University School Medicine, Saint Louis, MO 63108 State Key Laboratory Oral Diseases, Sichuan University, Chengdu 610041, China UT Southwestern, Dallas, TX 75390 Research Biotechnology Business Unit, Sigma-Aldrich Corporation, St. 63103 Division Gynecologic Obstetrics & Gynecology, Stanford...
Oral squamous cell carcinoma (OSCC) ranks among the most common cancer worldwide, and is associated with severe morbidity high mortality. submucous fibrosis (OSF), characterized by of mucosa upper digestive tract, a pre-malignant lesion, but molecular mechanisms underlying this malignant transformation remains to be elucidated. In study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was employed profile differentially expressed...
Oral submucous fibrosis (OSF) is a pre-cancerous lesion, which characterized by of the oral submucosa. Despite large body studies focusing on this disease, molecular mechanisms underlying progression OSF remained unclear. In study, 2-DE-based proteomic approaches were employed to identify differently expressed proteins between and normal tissues. total, 88 identified with altered expression levels, including CypA. Upregulation CypA was further validated through immunohistochemistry staining...
Abstract Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide, with 500 000 new cases each year. However, the mechanisms underlying OSCC development are relatively unknown. In this study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was used to profile differentially expressed peptides/proteins between tissues and their adjacent noncancerous tissues. Sixty-seven unique peptide peaks five...
Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common is strongly associated with mortality. It therefore critical to identify new targets for both treatment diagnostic purposes. We aimed at investigating the role of PA28α, a proteasomal activator OSCC.The expression PA28α was examined panel OSCC lines tissues, oncomine analysis. In large patient cohort, prognostic value evaluated. Primary clinical end points were...
Telomerase Cajal body protein 1 (TCAB1), which is involved in maintenance, telomere elongation and ribonucleoprotein biogenesis, has been linked to cancer predisposition, including nasopharyngeal carcinoma (NPC), due its oncogenic properties. However, there are no specific reports date on the functional relevance of TCAB1 Epstein-Barr virus (EBV), considered be a risk factor for NPC. In this study, we first examined NPC clinical tissues found notable overexpression EBV-positive specimens....
Oral squamous cell carcinoma (OSCC) is a leading malignancy worldwide; the overall 5-year survival rate approximately 50%. A variety of proteins in Toll-like receptors (TLRs) pathway have been related with risk OSCC. However, influence genetic variations TLRs genes on OSCC susceptibility unclear. Previous studies mainly focused coding region genes, while UTR remains unstudied. In current study, bioinformatics approach was performed to select candidate single nucleotide polymorphisms (SNPs)...
Epstein-Barr virus (EBV) infection is closely associated with nasopharyngeal carcinoma (NPC) and increases the chemotherapy resistance of tumor cells. Although mechanism by which EBV manipulates ataxia telangiectasia mutation (ATM)-mediated DNA damage response in NPC has been extensively studied, relationship between ATR (ATM Rad-3 related) largely unexplored, also role EBV-positive not specifically reported.Levels γ-H2AX, latent membrane protein 1 (LMP1), EBV-encoded RNA clinical...
Diosgenyl saponins possess a variety of biological functions. Herein, we demonstrate new type diosgenyl saponin derivatives that inhibit cellular proliferation oral squamous cell carcinoma (OSCC) lines. Thereafter, analyzed these cells' expression apoptosis-related proteins. Crucial proteins participate in apoptosis regulation including caspases 8, 9, and 3, cleaved Bid were activated upregulated accompanied by increased concentrations saponins. Meanwhile, Bcl-2 was downregulated...
In this study, 1 065 infants and young children aged 24 months below in ethnic minorities gathering poor rural areas of Liangshan Yi Autonomous Prefecture Sichuan Province Gannan Tibetan Gansu were investigated for their anemia status from October to November 2014, the association between utilization maternal child health services was analyzed. The prevalence area 52.68%(561/1 065). After adjustment socio-demographic characteristics mothers infants, compared with 2-5 months, Han group, whose...