A5101720646- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Diabetes Management and Research
- Galectins and Cancer Biology
- Veterinary medicine and infectious diseases
- Microplastics and Plastic Pollution
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Infectious Encephalopathies and Encephalitis
- Amino Acid Enzymes and Metabolism
- Natural Antidiabetic Agents Studies
- Plant pathogens and resistance mechanisms
- Tryptophan and brain disorders
- Ion Channels and Receptors
- Peripheral Neuropathies and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Glycation End Products research
Second Hospital of Shandong University
2016-2025
Creative Commons
2018
Nanchang University
2014
Medical Center Hospital
2014
Tri-ortho-cresyl phosphate (TOCP) has been widely used as plasticizers, plastic softeners, and flame retardants in industry reported to have a deleterious effect on the male reproductive system animals besides delayed neurotoxicity. Our preliminary results found that TOCP could disrupt seminiferous epithelium testis inhibit spermatogenesis, but precise mechanism is yet be elucidated. This study shows inhibited viability of rat spermatogonial stem cells dose-dependent manner. not lead cell...
Alzheimer disease (AD) is the most common form of dementia. Amyloid beta peptide (Aβ) deposition a major neuropathologic feature AD. When unfolded or misfolded proteins accumulate in mitochondria, protein responses (UPRmt) initiated. Numerous lines evidence show that AD pathologenesis involves mitochondrial dysfunction. However little known about whether UPRmt engaged process development. In this study, we investigated mouse and cell models We found was activated brain 3 9 months old APP/PS1...
Over a half of the diabetic individuals develop macrovascular complications that cause high mortality. Oxidative stress (OS) promotes endothelial dysfunction (ED) which is critical early step toward complications. Nuclear factor erythroid 2-related 2 (NRF2) master regulator cellular antioxidant defense system and combats diabetes-induced OS. Previously, we found impaired NRF2 signaling contributed to OS in mice. The present study has investigated effect microRNA-200a (miR-200a) on ED. In...
Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease, but the pathogenesis unclear. Damaged mitochondrial biogenesis has been observed in AD. Increasing evidence suggests that involved of AD, exact mechanism In this study, we used amyloid precursor protein Swedish mutations K594N/M595L (APPswe)/presenilin 1 with exon-9 deletion (PS1dE9) transgenic mouse model which was successfully established by expression β and presenilin (PS1). Then, compared APPswe/PS1dE9 mice...
Background: Neurotoxicity induced by the amyloid beta (Aβ) peptide is one of most important pathological mechanisms Alzheimer's disease (AD). Activation adaptive IRE1α-XBP1 pathway contributes to pathogenesis AD, making it a potential target for AD therapeutics. However, mechanism involvement in unclear. We, therefore, investigated effect axis an vitro model and explored its mechanism. Methods: The human neuroblastoma cell line, SH-SY5Y, was used. Cells were treated with Aβ25–35, or without...
Mitochondrial dysfunction plays a key role in the pathogenesis and progression of Alzheimer's Disease (AD). Our previous studies showed that over expression AD-associated mutant β-amyloid precursor protein (APP) led to abnormalities mitochondrial biogenesis mitophagy, leading dysfunction. However, mechanism remains unclear. In this study, we investigated effect orexin-A on biogenesis, mitophagy structure overexpression APP cells. We used 20E2 cells as AD cell model. were treated with (50,...
Background: Alzheimer’s disease (AD) is one of the common neurodegenerative diseases and characterized by accumulation amyloid-β (Aβ). Orexin-A a neuropeptide produced in hypothalamus thought to be involved pathogenesis AD. However, its underlying mechanism signaling pathway remains unclear. The aim this work was investigate effect on AD, explore potential pathway. Methods: SH-SY5Y cells that were stably transfected with Swedish mutant amyloid precursor protein (APPswe), cell model AD...
Abstract BackgroundThis study aims to further clarify whether there are cardiovascular and cerebrovascular benefits associated with insulin treatment combined metformin in individuals type 1 diabetes.MethodsElectronic databases were searched for randomized controlled trials which the efficacy safety of compared those a placebo disease among diabetes patients, meta-analysis was conducted.ResultsThirteen studies identified. In group, mean carotid intimal media thickness significantly reduced...