A5088758715- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Family and Disability Support Research
- Congenital Heart Disease Studies
- Cerebral Palsy and Movement Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Attention Deficit Hyperactivity Disorder
- Traumatic Brain Injury Research
- Reading and Literacy Development
- Epilepsy research and treatment
- Neonatal Respiratory Health Research
- Family Support in Illness
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Retinopathy of Prematurity Studies
- Neurological Complications and Syndromes
- Neonatal Health and Biochemistry
- Moyamoya disease diagnosis and treatment
- Intimate Partner and Family Violence
- Intensive Care Unit Cognitive Disorders
- Healthcare Decision-Making and Restraints
- Systemic Lupus Erythematosus Research
- Botulinum Toxin and Related Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Digital Mental Health Interventions
Hospital for Sick Children
2011-2024
University of Toronto
2008-2024
SickKids Foundation
2008-2024
Cincinnati Children's Hospital Medical Center
2024
British Columbia Children's Hospital
2024
York University
2022-2023
Australian and New Zealand Intensive Care Society
2020
Queen Elizabeth Hospital
2020
The University of Adelaide
2020
Monash University
2020
Abstract Background The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability RRT techniques and antibiotic relate observed trough concentrations to targets. Methods We performed a prospective, observational, multinational, pharmacokinetic study 29 intensive care units from 14 countries. collected demographic, clinical, data. measured meropenem, piperacillin-tazobactam, vancomycin related...
In China, the prevention and control of Zika virus disease has been a public health threat since first imported case was reported in February 2016. To determine vector competence potential mosquito species, we experimentally infected Aedes aegypti, Ae. albopictus, Culex quinquefasciatus mosquitoes determined infection rates, dissemination transmission rates. We found highest for aegypti mosquitoes, some susceptibility albopictus but no ability Cx. mosquitoes. Considering that, are widely...
The present study examined physical dating aggression in different adolescent relationships and assessed linear, threshold, moderator risk models for recurrent aggressive relationships. 621 participants (59% girls, 41% boys) were drawn from a 1-year longitudinal survey of Canadian high school youths ranging Grade 9 through 12. Approximately 13% reported across 2 Using peer dyadic factors Time 1 the study, authors confirmed linear model, such that adolescents violent had significantly more...
Caring for the complex needs of a child with congenital heart disease (CHD) can place significant burden on family. Parent mental health and coping have important influences resilience neurodevelopmental outcomes in children CHD. Objectives: To describe uptake cardiac program (CNP), examine parent specific to parenting CHD, explore relationship between outcomes. Method: Implementation CNP was examined, forty-four parents CHD completed DASS RSQ-CHD. Results: The showed follow-up interventions...
Importance During the 2023-2024 respiratory syncytial virus (RSV) season in United States, 2 new RSV prevention products were recommended to protect infants their first season: nirsevimab and Pfizer’s maternal vaccine. Postlicensure studies are needed assess product impact effectiveness. Objective To compare epidemiology disease burden of medically attended RSV-associated acute illness (ARI) among children younger than 5 years during with 3 prepandemic seasons (2017-2020), estimate...
The novel coronavirus, COVID-19, has led to sweeping changes in psychological practice and the concomitant rapid uptake of telepsychotherapy.Although telepsychotherapy is new many clinical psychologists, there considerable research on treatments.Nearly two decades treatments with children neurological conditions potential inform emerging age COVID-19.Toward that end, we synthesized findings from 14 trials problemsolving parent training interventions involving more than 800 families diverse...
Aim Moyamoya vasculopathy is characterized by progressive stenosis of the major arteries Circle Willis, resulting in compromised cerebral blood flow and increased risk stroke. The objectives current study were to examine intellectual executive functioning children with moyamoya evaluate impact type, stroke (clinical or silent), laterality, disease duration on neurocognitive abilities. Method Thirty pediatric participants (mean age 10y 10mo, SD 4y; 18 females, 12 males) completed...
To assess the prevalence of neurocognitive impairment (NCI) in childhood-onset systemic lupus erythematosus (cSLE) by comparing published classification criteria, and to examine associations between NCI, disease characteristics, psychosocial well-being, intelligence.
This study examined the prevalence of learning and psychological diagnoses associated neurological personal-environmental risk factors following perinatal childhood arterial ischemic stroke. In our sample 126 children youth, 52.4% received a diagnosis their assessment. Specifically, 32% had single 21% two or more diagnoses. Learning disability, attention deficit-hyperactivity disorder, intellectual disability were most prevalent Associated varied by with lower functioning being common factor...
This study compared rates of dating aggression among 16-year-old adolescents in Canada and Italy, as well differential associations with dyadic risk factors. 664 Canadians (297 boys, 367 girls) 578 Italians (315 263 indicated the frequency physical towards a romantic partner. They also rated level conflict power imbalance their relationship. The results revealed comparable two countries for both boys girls. Dyadic factors were significant, levels associated countries, uniquely linked Italy....
Childhood arterial ischemic stroke often involves basal ganglia and thalamus but little is known about neuropsychological outcomes in this group. We examined intellectual ability, academics, attention, executive function, psychological diagnoses children adolescents (6–20 years of age) with childhood involving the (n = 32) or 12). Intellectual ability was age-appropriate working memory significantly lower than expected. Compared to normative mean, group exhibited weaker performance reading...
The majority of pediatric neuropsychological stroke research has focused on perinatal outcomes given its relative frequency. Meanwhile, childhood-onset is under-represented in the literature, resulting limited knowledge about neurocognitive sequelae. This retrospective study examined cognitive children and youth (n = 27) with childhood arterial ischemic (stroke occurring between 29 days 18 years life) isolated to cortical region. Intellectual, academic, language, visual-perception,...
This cross-sectional retrospective clinical research study examines a large group of children followed within pediatric stroke program and developmental attention-deficit/hyperactivity disorder (ADHD) clinic at the Hospital for Sick Children, between May 2004 June 2016. All with history who participated in neuropsychological assessment ages 4 18 years were considered inclusion. From sample 275 participants stroke, 36 (13.1%) received diagnosis secondary ADHD. Children ADHD younger time more...
Abstract Objectives: The current study used a mixed-method design to qualitatively examine parents’ definitions of resilience and factors they believed optimized their child’s early outcome following neonatal brain injury. This was followed by quantitative analyses developmental mental health outcomes relation salient biopsychosocial factors. Methods: Participants were parents children diagnosed with injury due stroke or hypoxic-ischemic encephalopathy ( N =51; age range 18 months 8 years)....
Primary objective: This study aimed to create a specific questionnaire (Parent Experiences Questionnaire) about early experiences, service involvement, and needs of children parents following neonatal brain injury that could be used inform clinical care needed interventions.Research design methods: A mixed-method was utilized, engaging in both qualitative quantitative methods across three phases. Phase 1 employed participatory involving 12 parent clinician participants semi-structured...
Abstract Despite improved survival among children with congenital heart disease (CHD), the risk of psychosocial difficulties remains largely unchanged an increased emphasis improving support for parents as a mechanism to optimize outcomes. Objective Using qualitative and quantitative methods, current cross-sectional study examined parents' experiences at time their child's diagnosis, what they thought helped child recover, barriers support, identified needs future models care. Method The...
Objective We examined feasibility and acceptability of an adapted telepsychological parent-child intervention to improve parenting skills reduce emotional behavioural difficulties in Canadian families children at-risk for poor neurodevelopment given congenital or neonatal conditions. Preliminary program efficacy outcomes are also described.Methods Twenty-two between the ages 3–8 years with histories stroke, hypoxic ischemic encephalopathy (HIE) serious conditions [(congenital heart disease...
Abstract Objective To evaluate the feasibility, acceptability, and preliminary efficacy of a stepped-care parenting program implemented during COVID-19 among families behaviorally at-risk children with neurological or neurodevelopmental disorders aged 3–9 years. Methods Stepped-care I-InTERACT-North increased psychological support across 3 steps, matched to family needs: (1) guided self-help (podcast), (2) brief support, (3) longer-term parent support. The intervention was provided by...