A5000822953- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Airway Management and Intubation Techniques
- Blood Pressure and Hypertension Studies
- Non-Invasive Vital Sign Monitoring
- Pneumonia and Respiratory Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Renal function and acid-base balance
- Emergency and Acute Care Studies
- Family and Patient Care in Intensive Care Units
- Thermal Regulation in Medicine
- Heart Rate Variability and Autonomic Control
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antibiotic Resistance in Bacteria
- Palliative Care and End-of-Life Issues
- Antimicrobial Resistance in Staphylococcus
- Clinical Nutrition and Gastroenterology
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
Centre hospitalier universitaire d'Orléans
2016-2025
Intensive Care Society
2022-2024
French Clinical Research Infrastructure Network
2021-2023
Université Catholique de Lille
2023
Groupe Hospitalier de l'Institut Catholique de Lille
2023
Alberta Health Services
2022
University of Alberta
2022
Inserm
2014-2018
Centre Hospitalier Universitaire de Rennes
2018
Centre Hospitalier Universitaire de Poitiers
2018
Previous trials involving patients with the acute respiratory distress syndrome (ARDS) have failed to show a beneficial effect of prone positioning during mechanical ventilatory support on outcomes. We evaluated early application outcomes in severe ARDS.In this multicenter, prospective, randomized, controlled trial, we randomly assigned 466 ARDS undergo prone-positioning sessions at least 16 hours or be left supine position. Severe was defined as ratio partial pressure arterial oxygen...
Whether noninvasive ventilation should be administered in patients with acute hypoxemic respiratory failure is debated. Therapy high-flow oxygen through a nasal cannula may offer an alternative hypoxemia.
Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy hydrocortisone plus fludrocortisone or drotrecogin alfa (activated), which can modulate response, would improve clinical outcomes patients septic shock.
ANY PHYSICIANS BELIEVEthat the pulmonary artery catheter (PAC) is useful for diagnosis and treatment of cardiopulmonary disturbances assessing volume status in critically ill patients. 1,2However, investigators have raised doubts about safety PAC 3,4 because its use may be associated with direct complications 5 or harmful effects related to inappropriate decisions resulting from misinterpretation data. 6he most serious concern was by retrospective study Connors et al, 4 which suggested that...
Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate patients nonshockable rhythms (asystole or pulseless electrical activity) debated.
Reignier, Jean*†; Mercier, Emmanuelle‡; Le Gouge, Amelie§; Boulain, Thierry║; Desachy, Arnaud¶; Bellec, Frederic#; Clavel, Marc**; Frat, Jean-Pierre††; Plantefeve, Gaetan‡‡; Quenot, Jean-Pierre§§; Lascarrou, Jean-Baptiste* For the Clinical Research in Intensive Care and Sepsis Group Author Information
In the intensive care unit (ICU), orotracheal intubation can be associated with increased risk of complications because patient may acutely unstable, requiring prompt intervention, often by a practitioner nonexpert skills. Video laryngoscopy decrease this improving glottis visualization.To determine whether video increases frequency successful first-pass compared direct in ICU patients.Randomized clinical trial 371 adults while being treated at 7 ICUs France between May 2015 and January...
In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional therapy. Endotracheal intubation is frequently needed in these a risk of delay, early predictors failure may help clinicians decide early. We aimed identify factors associated treated different oxygenation techniques.Post hoc analysis randomized clinical trial.Twenty-three ICUs.Patients rate greater than 25 breaths/min PaO2/FIO2 ratio...
<h3>Importance</h3> Early in-bed cycling and electrical muscle stimulation may improve the benefits of rehabilitation in patients intensive care unit (ICU). <h3>Objective</h3> To investigate whether early leg plus quadriceps muscles added to standardized would result greater strength at discharge from ICU. <h3>Design, Setting, Participants</h3> Single-center, randomized clinical trial enrolling critically ill adult 1 ICU within an 1100-bed hospital France. Enrollment lasted July 2014 June...
Prone positioning may improve outcomes in patients with severe acute respiratory distress syndrome (ARDS), but it is unknown whether prone improves clinical among ARDS who are undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) compared supine positioning.
To evaluate the mortality rate attributable to nosocomial ventilator-associated pneumonia in an intensive care unit.Prospective, matched, risk-adjusted cohort study.A 18-bed adult medical-surgical unit a 1,100-bed regional and teaching hospital France.From January 1, 1996, April 30, 1999, 135 patients who developed were matched with control without pneumonia.None.Nosocomial was identified on basis of results distal bronchial samples. The matching process conducted according following primary...
Objective To evaluate the obesity-related mortality rate in an intensive care unit. Design An exposed/unexposed matched cohort study. Setting 18-bed adult medical-surgical unit a 1,100-bed regional and teaching hospital France. Patients From January 1, 1999, to December 31, 2001, 170 mechanically ventilated exposed patients (obese with body mass index of >30 kg/m2) were unexposed (with ideal 18.5–24.9 kg/m2). Interventions None. Measurements Main Results The matching process was conducted...
The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk describe the UEX. followed 426 over 2-mo period. Clinical characteristics such as diagnosis on admission reasons for ventilation were used classify patients. presence or absence potential was daily noted, including types ventilators, tracheal tubes, tube fixations, ventilatory...
Despite advances in care, mortality and morbidity remain high adults with acute bacterial meningitis, particularly when due to Streptococcus pneumoniae. Induced hypothermia is beneficial other conditions global cerebral hypoxia.To test the hypothesis that induced improves outcome patients severe meningitis.An open-label, multicenter, randomized clinical trial 49 intensive care units France, February 2009-November 2011. In total, 130 were assessed for eligibility 98 comatose (Glasgow Coma...
Unlike for septic shock, there are no specific international recommendations regarding the management of cardiogenic shock (CS) in critically ill patients. We present herein adults, developed with Grading Recommendations Assessment, Development, and Evaluation (GRADE) system by an expert group French-Language Society Intensive Care (Société de Réanimation Langue Française (SRLF)), participation French Anesthesia (SFAR), Cardiology (SFC), Emergency Medicine (SFMU), Thoracic Cardiovascular...
Targeted temperature management is recommended after out-of-hospital cardiac arrest. Whether advanced internal cooling superior to basic external remains unknown. The aim of this multicenter, controlled trial was evaluate the benefit endovascular versus surface cooling.Inclusion criteria were following: age 18 79 years, arrest related a presumed cause, time return spontaneous circulation <60 minutes, delay between and inclusion <240 unconscious patient before start cooling. Exclusion...
Rationale: Intensive care unit (ICU) beds are a scarce resource, and patients denied intensive only because the is full may be at increased risk of death.Objective: To compare mortality after first ICU referral in admitted admission was full.Methods: Prospective observational multicenter cohort study consecutive referred for during two 45-day periods, conducted 10 ICUs.Measurements Main Results: Of 1,762 patients, 430 were excluded from study, 116 with previously to another 270 they deemed...