G. Béduneau
A5030036050- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Dysphagia Assessment and Management
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Healthcare Decision-Making and Restraints
- Clinical Nutrition and Gastroenterology
- Bacterial Infections and Vaccines
- Pleural and Pulmonary Diseases
- Healthcare Systems and Practices
- Frailty in Older Adults
- Pneumocystis jirovecii pneumonia detection and treatment
- Emergency and Acute Care Studies
Université de Rouen Normandie
2016-2025
Hôpital Charles-Nicolle
2010-2025
Normandie Université
2016-2025
Centre Hospitalier Universitaire de Rouen
2013-2024
Groupe de Recherche sur le Handicap Ventilatoire et Neurologique
2024
Inserm
2019-2023
Université de Strasbourg
2023
Research Network (United States)
2023
French Clinical Research Infrastructure Network
2023
Université de Tours
2023
Whether noninvasive ventilation should be administered in patients with acute hypoxemic respiratory failure is debated. Therapy high-flow oxygen through a nasal cannula may offer an alternative hypoxemia.
The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial.
The weaning process concerns all patients receiving mechanical ventilation. A previous classification into simple, prolonged, and difficult ignored failure presupposed the use of spontaneous breathing trials.To describe process, defined as starting with any attempt at separation from ventilation its prognosis, according to a new operational working for under ventilation.This was multinational prospective multicenter observational study over 3 months in 36 intensive care units, daily...
Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV may result in shorter time to tracheal extubation than T-piece trials, without resulting higher risk reintubation, among patients who have high failure is unknown.In this multicenter, open-label trial, we randomly assigned had (i.e., were >65 years age an underlying chronic cardiac respiratory disease) undergo spontaneous-breathing (with level 8 cm water and no...
BackgroundWhether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear.MethodsIn this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive amikacin a dose 20 mg per kilogram ideal body weight once daily or placebo 3 days. The primary outcome was first episode during 28 days...
Prone positioning may improve outcomes in patients with severe acute respiratory distress syndrome (ARDS), but it is unknown whether prone improves clinical among ARDS who are undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) compared supine positioning.
Objective: To describe the diagnostic yields of test strategies with and without fiberoptic bronchoscopy bronchoalveolar lavage (FO-BAL), as well outcomes, in cancer patients acute respiratory failure (ARF). Design: Prospective observational study. Setting: Fifteen intensive care units France. Patients: In all, 148 patients, including 45 bone marrow transplant recipients (27 allogeneic, 18 autologous) hypoxemic ARF. Intervention: None. Results: Overall, 146 causes ARF were identified 128 (97...
Rationale: Difficult weaning from mechanical ventilation is often associated with fluid overload. B-type natriuretic peptide (BNP) has been proposed as a tool for predicting and detecting failure of cardiovascular origin.Objectives: To investigate whether management guided by daily BNP plasma concentrations improves outcomes compared empirical therapy dictated clinical acumen.Methods: In randomized controlled multicenter study, we allocated 304 patients to either BNP-driven or...
During proportional assist ventilation with load-adjustable gain factors, peak respiratory muscle pressure can be estimated from the airway and percentage of assistance (gain). Adjusting can, therefore, target a given level effort. This study assessed clinical feasibility titrating factors goal targeting predefined range effort.Prospective, multicenter, observational study.Intensive care departments at five university hospitals.Patients were included after meeting simple criteria for...
Abstract Background The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis older patients (> 70 years old) with admitted intensive unit (ICU). Methods Characteristics, management, critically ill old years) were extracted from international prospective COVID-ICU database. A propensity score weighted-comparison evaluated impact intubation upon admission Day-90 mortality. Results...
Rationale: Although noninvasive ventilation (NIV) may prevent reintubation in patients at high risk of extubation failure ICUs, this oxygenation strategy has not been specifically assessed obese patients. Objectives: We hypothesized that NIV decrease the compared with high-flow nasal oxygen. Methods:Post hoc analysis a multicenter randomized controlled trial (not prespecified) comparing alternating oxygen versus alone after extubation, aim assessing effects according to patient body mass...
To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate mortality in COVID-19 patients admitted to intensive care units (ICUs). Multicenter, prospective cohort study (COVID-ICU) 137 hospitals France, Belgium, Switzerland. Demographic, clinical, respiratory support, failure, survival data were collected. Oxygenation was defined as either intubation or death ICU without intubation. Variables...
Objective: To assess the effect of a helium-oxygen mixture on intubation rate and clinical outcomes during noninvasive ventilation in acute exacerbation chronic obstructive pulmonary disease. Design: Multicenter, prospective, randomized, controlled trial. Setting: Seven intensive care units. Patients: A total 204 patients with known or suspected disease dyspnea, Paco2> 45 mm Hg two among following factors: pH <7.35, Paco2 <50 Hg, respiratory >25/min. Interventions: Noninvasive randomly...
Background Increasing numbers of studies in chronic diseases have been published showing the relationship between body composition (BC) parameters (i.e. skeletal muscle mass (SMM) and adipose tissue (AT)) outcomes. For patients admitted to intensive care unit (ICU), BC rarely described as a prognostic marker outcome. The primary objective was evaluate at ICU admission major clinical Secondary objectives were assess other (systemic inflammatory markers, Sequential Organ Failure Assessment...
Thrombocytopenia is a common, multifactorial, finding in ICU. Hemophagocytosis one of the main explanatory mechanisms, possibly integrated into hemophagocytic lymphohistiocytosis syndrome, infectious origin majority cases The probably underdiagnosed ICU, although it associated with dramatic outcomes. objectives this work were to identify frequency secondary lymphohistiocytosis, and prognostic factors for mortality.We conducted retrospective observational study all adult patients admitted...
Background: An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short-and long-term survival.The subject is noteworthy deserves be discussed. Methods:Twenty-two ICUs in France performed screenings patients admitted between January 2000 December 2014.Retrospective data were collected from hospital databases through the registers town hall patients.Results: Seventy included 15 different...
Abstract Introduction Studies regarding coronavirus disease 2019 (COVID-19) were mainly performed in the initial wave, but some small-scale data points to prognostic differences for patients successive waves. We therefore aimed study impact of time on prognosis ICU-admitted COVID-19 patients. Method a national retrospective cohort study, including all adult hospitalized French ICUs from March 1, 2020 June 30, 2021, and identified three surge periods. Primary secondary outcomes in-hospital...
Abstract Introduction End-expiratory lung volume (EELV) is decreased in acute respiratory distress syndrome (ARDS), and bedside EELV measurement may help to set positive end-expiratory pressure (PEEP). Nitrogen washout/washin for available at the bedside, but assessments of accuracy precision real-life conditions are scant. Our purpose was (a) assess ARDS patients two PEEP levels (three pairs measurements), (b) compare changes (Δ) induced by total with PEEP-induced above functional residual...
RECOMMENDATIONS Méthodologieces recommandations sont le résultat du travail d'un groupe d'experts réunis par la société de réanimation langue française (sRLF).Les différentes disciplines contribuant à prise en charge mobilisation des patients Prise précoce réanimation, chez l'adulte et l'enfant (électrostimulation incluse) Management of early (including electrostimulation) in adult and pediatric the intensive care unit Recommandations formalisées d'expertsSous l'égide Société (SRLF) Avec...