A5111685495- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Central Venous Catheters and Hemodialysis
- Cardiac electrophysiology and arrhythmias
- Antibiotic Use and Resistance
- Peripheral Artery Disease Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Reconstructive Surgery and Microvascular Techniques
- Ultrasound in Clinical Applications
- Gastroesophageal reflux and treatments
- Cardiovascular Health and Disease Prevention
- Case Reports on Hematomas
- Virology and Viral Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Parvovirus B19 Infection Studies
Bicêtre Hospital
2013-2025
Assistance Publique – Hôpitaux de Paris
2010-2025
Université Paris-Saclay
2005-2025
Somali National University
2024
Hôpital Foch
2024
Centre Paul Albert-Février
2024
Inserm
2018
Tengku Ampuan Rahimah Hospital
2016
HES-SO Genève
2013
Emory University
2012
OSITIVE END-EXPIRATORY PRESsure (PEEP) is an essential component of the management acute lung injury (ALI) and respiratory distress syndrome (ARDS). 1 PEEP improves hypoxemia decreases intrapulmonary shunting, these effects have been basis for titrating in clinical practice. 24][5][6] Although mechanisms this protective effect are not fully elucidated, they may be mediated by PEEP-induced alveolar recruitment, which avoids cyclic air-See also pp 637, 691, 693.
Passive leg raising (PLR) represents a "self-volume challenge" that could predict fluid response and might be useful when the respiratory variation of stroke volume cannot used for purpose. We hypothesized hemodynamic to PLR predicts responsiveness in mechanically ventilated patients.Prospective study.Medical intensive care unit university hospital.We investigated 71 patients considered expansion. Thirty-one had spontaneous breathing activity and/or arrhythmias.We assessed status at...
Values of central venous pressure 8-12 mm Hg and pulmonary artery occlusion 12-15 have been proposed as volume resuscitation targets in recent international guidelines on management severe sepsis. By analyzing a large number challenges, our aim was to test the significance recommended target values terms prediction responsiveness.Retrospective study.A 24-bed medical intensive care unit.All consecutive septic patients monitored with catheter who underwent challenge between 2001 2004.None.A...
During mechanical ventilation, inspiration cyclically decreases the left cardiac preload. Thus, an end-expiratory occlusion may prevent cyclic impediment in preload and act like a fluid challenge. We tested whether this could serve as functional test for responsiveness patients with circulatory failure.Prospective study.Medical intensive care unit.Thirty-four mechanically ventilated shock whom volume expansion was planned.A 15-second followed by 500 mL saline infusion.Arterial pressure pulse...
Acute respiratory distress syndrome might be associated with an increase in extravascular lung water index and pulmonary vascular permeability index, which can measured by transpulmonary thermodilution. We tested whether are independent prognostic factors patients acute syndrome.Retrospective study.Medical intensive care unit.Two hundred consecutive (age = 57 ± 17, Simplified Physiology Score II 20, overall day-28 mortality 54%).Extravascular were collected (PiCCO device, Pulsion Medical...
Abstract Background Little is known about the most severe forms of Pneumocystis jiroveci pneumonia (PCP) in HIV-negative as compared with HIV-positive patients. Improved knowledge differential characteristics and management modalities could guide treatment based on HIV status. Methods We retrospectively 72 patients (73 cases, 46 HIV-positive) admitted for PCP from 1993 to 2006 intensive care unit (ICU) a university hospital. Results The yearly incidence ICU admissions increased (0%) (6.5%)....
Objectives: To examine whether the agreement between pulse contour and transpulmonary thermodilution cardiac index (CI) measurements is altered by changes in vascular tone within an up to 6-hr calibration-free period. Design: Observational study. Setting: Medical intensive care unit of a university hospital. Patients: Fifty-nine critically ill patients. Interventions: None. Measurements Main Results: Data from 59 patients equipped with PiCCO device were retrospectively analyzed. The database...
The hemodynamic impact of positive end-expiratory pressure in acute respiratory distress syndrome and the underlying mechanisms have not been extensively investigated during low stretch ventilation. Our aim was to evaluate effect increasing when tidal volume plateau are limited explore mechanisms.Prospective study.Medical intensive care unit.Twenty-one patients ventilated with a 6.0 +/- 0.5 mL/kg predicted body weight.Positive significantly increased from 5 1 cm H2O 13 4 for reaching 30 H2O....
Weaning-induced pulmonary edema is a cause of weaning failure in high-risk patients. The diagnosis may require artery catheterization to demonstrate increased occlusion pressure (PAOP) during weaning. Transthoracic echocardiography can estimate left ventricular filling pressures using early (E) and late (A) peak diastolic velocities measured with Doppler transmitral flow, tissue imaging mitral annulus including (Ea) velocity. We tested the hypothesis that E/A E/Ea could be used detect...
Acute renal failure (ARF) in critically ill patients is currently very frequent and requires replacement therapy (RRT) many patients. During the last 15 years, several studies have considered important issues regarding use of RRT ARF, like time to initiate therapy, dialysis dose, types catheter, choice technique, anticoagulation. However, despite an abundant literature, conflicting results do not provide evidence on implementation. We present herein recommendations for adult pediatric...
To evaluate to which extent the systemic arterial pulse pressure could be used as a surrogate of cardiac output for assessing effects fluid challenge and norepinephrine.Observational study.Medical intensive care unit.Patients with an acute circulatory failure who received (228 patients, group 1) or in whom norepinephrine was introduced increased (145 2).We measured systolic, diastolic, mean pressure, transpulmonary thermodilution before after therapeutic interventions.In 1, significantly by...
Abstract Introduction Data on pulmonary complications in renal transplant recipients are scarce. The aim of this study was to evaluate acute respiratory failure (ARF) recipients. Methods We conducted a retrospective observational nine centers consecutive kidney admitted the intensive care unit (ICU) for ARF from 2000 2008. Results Of 6,819 recipients, 452 (6.6%) required ICU admission, including 200 ARF. Fifteen (7.5%) these patients had combined kidney-pancreas transplantations. most common...
Introduction Primary factor VIII ( FVIII ) prophylaxis is the optimal treatment in children with severe haemophilia A. They are expected to benefit from extended half‐life T 1/2 coverage by reduced infusion frequency while maintaining haemostatic efficacy. Aims To determine immunogenicity, pharmacokinetics PK ), efficacy, safety and quality of life a polyethylene glycol (peg)‐ylated BAX 855) based on full‐length recombinant ADVATE paediatric previously treated patients PTP s) Methods s...
Objective: Fluid responsiveness requires the accurate measurement of cardiac output that can be approached by aortic blood flow (ABF) as measured esophageal Doppler monitoring (EDM). EDM devices may either include an echo-determination diameter or estimate from nomograms and thus consider it constant. However, is unclear if measuring increases accuracy to identify fluid responsiveness. Aortic varies with arterial pressure such its measure could essential for assessing changes in ABF during...
Intensivists are regularly confronted with the question of gastrointestinal bleeding. To date, latest international recommendations regarding prevention and treatment for bleeding lack a specific approach to critically ill patients. We present management by intensivist in adults children, developed GRADE system an experts group French-Language Society Intensive Care (Société de Réanimation Langue Française (SRLF), participation French Language Group Paediatric Emergencies (GFRUP), Emergency...
RECOMMENDATIONS Méthodologieces recommandations sont le résultat du travail d'un groupe d'experts réunis par la société de réanimation langue française (sRLF).Les différentes disciplines contribuant à prise en charge mobilisation des patients Prise précoce réanimation, chez l'adulte et l'enfant (électrostimulation incluse) Management of early (including electrostimulation) in adult and pediatric the intensive care unit Recommandations formalisées d'expertsSous l'égide Société (SRLF) Avec...
During the weaning process, transition from positive to negative pressure ventilation may induce cardiac dysfunction, which lead pulmonary oedema. The incidence of weaning-induced oedema (WIPO) is poorly documented and shows huge variations. Our study aims investigate risk factors for WIPO during mechanical in general critically ill patients. This multicentre was conducted France, Italy, India. Adult patients receiving invasive were included once a spontaneous breathing trial (SBT)...
Long-term outcomes of patients with severe stroke remain poorly documented. We aimed to characterize one-year requiring mechanical ventilation in the intensive care unit (ICU).We conducted a prospective multicenter cohort study 33 ICUs France (2017-2019) on consecutive strokes for at least 24 hours. Outcomes were collected via telephone interviews by an independent research assistant. The primary end point was poor functional outcome, defined modified Rankin Scale score 4 6 1 year....