A5016317283- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Thermal Regulation in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Healthcare Technology and Patient Monitoring
- Cardiovascular Function and Risk Factors
- Bacterial Infections and Vaccines
- Otolaryngology and Infectious Diseases
- Antifungal resistance and susceptibility
- Healthcare cost, quality, practices
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Family and Patient Care in Intensive Care Units
- Health Systems, Economic Evaluations, Quality of Life
Hospices Civils de Lyon
2016-2025
Laboratoire CarMeN
2016-2025
Hôpital Edouard Herriot
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Inserm
2010-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2025
University of Cape Town
2018-2024
Institut Pasteur de la Guadeloupe
2023
Maternité Port Royal
2023
HCL Technologies (India)
2022
Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management these patients.To identify prognostic factors good neurologic outcome in patients admitted to an ICU with anti-NMDAR encephalitis.This was observational multicenter study all consecutive adult diagnosed encephalitis at French National Reference Centre, between 2008 and 2014. The primary a 6 months...
COVID-19 pneumonia typically begins with subpleural ground glass opacities progressive extension on computerized tomography studies. Lung ultrasound is well suited to this interstitial, involvement, and it now broadly used in intensive care units (ICUs). The severity of lung infiltrates can be described numerically a reproducible validated score (LUSS). We hypothesized that LUSS might useful as tool non-invasively monitor the evolution at bedside. monitoring was rapidly implemented...
OBJECTIVES: Prone position is used in acute respiratory distress syndrome and coronavirus disease 2019 syndrome. However, it unclear how responders may be identified whether an oxygenation response improves outcome. The objective of this study was to quantify the prone position, describe differences between syndrome, explore variables associated with survival. DESIGN: Retrospective, observational, multicenter, international cohort study. SETTING: Seven ICUs Italy, United Kingdom, France....
We aimed at assessing the efficacy and safety on antibiotic exposure of a strategy combining respiratory multiplex PCR (mPCR) with enlarged panel daily procalcitonin (PCT) measurements, as compared conventional strategy, in adult patients who were critically ill laboratory-confirmed SARS-CoV-2 pneumonia.This multicentre, parallel-group, open-label, randomized controlled trial enrolled admitted to 13 intensive care units (ICUs) France. Patients assigned (1:1) control which streamlining...
AimsResuscitated cardiac arrest (CA), leading to harmful cardiovascular dysfunction and multiple organ failure, includes a whole-body hypoxia–reoxygenation phenomenon. Opening of the mitochondrial permeability transition pore (mPTP) appears be pivotal event in ischaemia–reperfusion injury. We hypothesized that pharmacological inhibition mPTP opening may prevent post-CA syndrome.
Experimental evidence suggests that cyclosporine prevents postcardiac arrest syndrome by attenuating the systemic ischemia reperfusion response.To determine whether early administration of at time resuscitation in patients with out-of-hospital cardiac (OHCA) would prevent multiple organ failure.A multicenter, single-blind, randomized clinical trial was conducted from June 22, 2010, to March 13, 2013 (Cyclosporine A Out-of-Hospital Cardiac Arrest Resuscitation [CYRUS]). Sixteen intensive care...
In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions. The capacity of these severe patients mount a robust and persistent specific T cell despite presence alterations during ICU stay unknown. Critically were sampled five times 9 13 months afterwards. Immune monitoring included counts lymphocyte subpopulations, HLA-DR expression on monocytes, plasma IL-6 IL-10 concentrations, anti-SARS-CoV-2 IgG levels proliferation in...
Metformin-associated lactic acidosis (MALA) is a severe metabolic failure with high related mortality. Although its use controversial, intermittent hemodialysis reported to be the most frequently used treatment in conjunction nonspecific supportive measures. Our aim was report evolution and outcome of cases managed by continuous renal replacement therapy (CRRT).Over 3-year period, we retrospectively identified patients admitted intensive care unit for caused metformin. We included our study...
To identify the factors associated with interindividual pharmacokinetic (PK) variability of micafungin and to evaluate probability reaching previously determined PK/pharmacodynamic efficacy thresholds (AUC/MIC >5000 for non-parapsilosis Candida sp. ≥285 parapsilosis) recommended 100 mg daily dose in ICU patients sepsis mechanical ventilation. One hundred were included 436 concentrations available PK analysis performed NONMEM software. PTA was by Monte Carlo simulations. Micafungin obeyed a...
Since the onset of pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, question whether parameters drive or associate delayed unfavorable outcome these remains unsolved. We present a dynamic description immuno-inflammatory derangements 64 including plasma IFNα2 levels and IFN-stimulated genes (ISG) score measurements. ARDS...
Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs mortality. To date, no biomarker has shown sufficient evidence ease of application clinical routine for the identification patients at risk IAI. We evaluated association systemic mRNA expression two host response biomarkers, CD74 IL10, with IAI occurrence a large cohort patients.ICU were prospectively enrolled multicenter study. Whole blood was collected on day admission (D1) 3 (D3) 6 (D6)...
Background Acute epiglottitis is a potentially life threatening disease, with growing incidence in the adult population. Its long-term outcome after Intensive Care Unit (ICU) hospitalization has rarely been studied. Methodology and Principal Findings Thirty-four patients admitted for acute were included this retrospective multicentric study. The mean age was 44±12 years (sex ratio: 5.8). Sixteen (47%) had history of smoking while 8 (24%) no previous medical history. average time disease...
We report an immunocompetent patient who had fatal encephalopathy after mild influenza. He rapidly died unusual symptoms related to intracerebral thrombosis and hemorrhage. A brain biopsy specimen was positive for influenza A(H1N1)pdm09 virus RNA, but a lung cerebrospinal spinal fluid samples were negative.
Chemokine (C-X3-C motif) receptor 1 (CX3CR1) was identified as the most differentially expressed gene between survivors and non-survivors in two independent cohorts of septic shock patients proposed a marker sepsis-induced immunosuppression. Whether such biomarker is associated with mortality heterogeneous group critically ill unknown. The primary objective this study to evaluate association CX3CR1 messenger RNA (mRNA) expression intensive care unit (ICU) patients. secondary similar...