A5061441162- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- interferon and immune responses
- Respiratory viral infections research
- COVID-19 and Mental Health
- Trauma and Emergency Care Studies
- Dialysis and Renal Disease Management
- Family and Patient Care in Intensive Care Units
- Thermal Regulation in Medicine
- Kawasaki Disease and Coronary Complications
- Neuroscience of respiration and sleep
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Outbreaks Research
- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
Université Claude Bernard Lyon 1
2016-2025
Hospices Civils de Lyon
2016-2025
Hôpital de la Croix-Rousse
2016-2025
Hôpital Nord
2022-2024
All India Institute of Medical Sciences Raipur
2023
All India Institute of Medical Sciences Rishikesh
2023
Université de Lyon
2021
Institut National des Sciences Appliquées de Lyon
2021
Inserm
2016-2021
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2020-2021
MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 and CD8 T cells that poorly respond to SARS-CoV-2 antigens.
IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2 infection. We analyze IFN-I/III signature, namely expression of ISGF-3-dependent IFN-stimulated genes, mildly symptomatic COVID-19 patients show its correlation with serum IFN-α2 levels, which peak at symptom onset return to baseline from day 10 onward. Moreover, signature correlates nasopharyngeal viral load associated presence infectious viruses. By contrast, we observe low scores despite high loads a...
Impairment of type I interferon (IFN-I) immunity has been reported in critically ill COVID-19 patients. This defect can be explained a subset patients by the presence circulating autoantibodies (auto-Abs) against IFN-I. We set out to improve detection and quantification IFN-I auto-Abs cohort patients, order better evaluate prevalence these Abs as pandemic progresses, how they correlate with clinical course disease. The concentration anti-IFN-α2 was determined serum 84 who were admitted ICU...
Net ultrafiltration (UF
Introduction The optimal method for removing the endotracheal tube (ETT) during extubation in intensive care unit (ICU) remains uncertain. Two methods are described ETT ICU, namely ‘Traditional technique’ with continuous aspiration cuff deflation and removal; ‘PEEP’ method, which consists applying positive end-expiratory pressure (PEEP) before removal. Our hypothesis is that PEEP ICU would improve clinical outcome. Methods analysis This a prospective, multicentre, randomised, open-label,...
In acute respiratory distress syndrome (ARDS) patients, it has recently been proposed to set positive end-expiratory pressure (PEEP) by targeting transpulmonary pressure. This approach, which relies on the measurement of absolute esophageal (Pes), used in supine position (SP) and not investigated prone (PP). Our purposes were assess Pes-guided strategy PEEP SP PP as compared with a PEEP/FIO2 table explore early (1 h) late (16 effects lung chest wall mechanics. We performed prospective,...
Protracted viral shedding is common in hospitalized patients with COVID-19 pneumonia, and up to 40% display signs of pulmonary fibrosis on computed tomography (CT) after hospital discharge. We hypothesized that acute respiratory failure (ARF) who die intensive care units (ICU) have a lower clearance the tract than ICU discharged alive, protracted samples associated patterns fibroproliferation lung CT. We, therefore, conducted retrospective observational study, 2 Lyon university hospital. 129...
Immunological disturbances (anti-type I IFN auto-antibody production, cytokine storm, lymphopenia, T-cell hyperactivation and exhaustion) are responsible for disease exacerbation during severe COVID-19 infections. In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) performed therapeutic plasma exchange (TPE) in patients order to decrease excess cytokines auto-antibodies assess whether adding TPE the standard treatment (ST, including...
Abstract Background Patients with ARDS have heterogeneous lungs which exposes them to the risk of lung injury exacerbation by mechanical ventilation. Functional CT imaging gives a comprehensive description regional behaviour. Here, we investigated whether registration-based function parameters are associated survival in patients COVID-ARDS. Methods We conducted two-centre prospective observational study adult COVID-ARDS an indication for within 72 h onset. Dual volume images were aligned...
Panwar and colleagues recently reported the results of a prospective multicenter international interventional trial comparing two oxygenation targets in all-comer patients receiving invasive mechanical ventilation ICU, namely conservative (SpO2 88–92%) versus liberal target (≥96%), by accommodating FIO2 (1). The rationale behind this was that no previous done to compare different goals mechanically ventilated patients. Even though oxygen therapy is frequently used critical care setting, its...
During spontaneous breathing trial, low-pressure support is thought to compensate for endotracheal tube resistance, but it actually should provide overassistance. Automatic compensation an option available in the ventilator flow-resistance of tube. Its effects on patient effort have been poorly investigated. We aimed compare and automatic during trial power lung ventilation distribution.We performed a randomized crossover study 20 patients ready wean. Each received both methods 30 min...
Expiratory flow limitation (EFL) and airway closure (AC) were observed in 32% 52%, respectively, of 25 patients with ARDS investigated during mechanical ventilation supine position a positive end-expiratory pressure 5 cmH2O. The performance dynamic lung elastance to detect expiratory was good better than that closure. vast majority EFL also had AC; however, AC can occur the absence EFL.
Abstract Background Hemodynamic instability is a frequent complication of continuous renal replacement therapy (CRRT). Postural tests (i.e., passive leg raising in the supine position or Trendelenburg maneuver prone position) combined with measurement cardiac output are highly reliable to identify preload-dependence and may provide new insights into mechanisms involved hemodynamic related CRRT (HIRRT). We aimed assess prevalence risk factors HIRRT associated ICU patients. conducted...
Assessing measurement error in alveolar recruitment on computed tomography (CT) is of paramount importance to select a reliable threshold identifying patients with high potential for and rationalize positive end-expiratory pressure (PEEP) setting acute respiratory distress syndrome (ARDS). The aim this study was assess both intra- inter-observer smallest real difference (SRD) exceeding using human machine learning-made lung segmentation (i.e., delineation) CT. This single-center...
Abstract Background The aim of this study is to assess whether a strategy combining spontaneous breathing trial (SBT) with both pressure support (PS) and positive end-expiratory (PEEP) extended use post-extubation non-invasive ventilation (NIV) (extensively-assisted weaning) would shorten the time until successful extubation as compared SBT T-piece (TP) NIV performed in selected patients advocated by guidelines (standard weaning), difficult-to-wean from mechanical ventilation. Methods...
Abstract Background A 10-day dexamethasone regimen has emerged as the internationally adopted standard-of-care for severe COVID-19 patients. However, immune response triggered by SARS-CoV-2 infection remains a complex and dynamic phenomenon, leading to various profiles trajectories. The status of patients following complete treatment yet be thoroughly documented. Results To analyze monocyte HLA-DR expression (mHLA-DR) CD4 + T lymphocyte count (CD4) in critically ill after course evaluate...
The authors regret that in the original version of this paper, Hadjadj et al. ( 2020) was cited instead Bastard (2020) a sentence about auto-Abs Introduction.The corrected is below."This defect explained some patients by inborn genetic defects IFN-I induction or amplification (Zhang al., 2020b) and others presence neutralizing autoantibodies (auto-Abs) against type I IFNs, mainly IFN-α and/or IFN-ω and, rare cases, IFN-β (Bastard 2020).