A5027089403- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Kawasaki Disease and Coronary Complications
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Pediatric Pain Management Techniques
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Airway Management and Intubation Techniques
- Craniofacial Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare Decision-Making and Restraints
- Inhalation and Respiratory Drug Delivery
- Inflammasome and immune disorders
- Bacterial Infections and Vaccines
- Toxin Mechanisms and Immunotoxins
- Viral Infections and Immunology Research
- Health, Medicine and Society
- Cerebral Venous Sinus Thrombosis
- Neonatal and fetal brain pathology
Hôpital Femme Mère Enfant
2012-2024
Hospices Civils de Lyon
2013-2024
Hôpital Lyon Sud
2023
<h3>Importance</h3> Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with acute respiratory coronavirus 2 infection, potentially life-threatening, but optimal therapeutic strategy remains unknown. <h3>Objective</h3> To compare intravenous immunoglobulins (IVIG) plus methylprednisolone vs IVIG alone as initial therapy MIS-C. <h3>Design, Setting, and Participants</h3> Retrospective cohort study drawn from a national surveillance system...
MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 and CD8 T cells that poorly respond to SARS-CoV-2 antigens.
Multisystem inflammatory syndrome in children (MIS-C) is the most severe clinical entity associated with pediatric SARS-CoV-2 infection a putative role of spike protein into immune system activation. Whether COVID-19 mRNA vaccine can induce this complication unknown. We aimed to assess risk hyper-inflammatory following children.
Asthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) a recent device that now used as primary support for respiratory distress. Several studies have reported use of NHF status asthmaticus; however, there are no data to recommend such practice. We therefore conducted this preliminary study evaluate therapy with asthmaticus admitted our PICU order prepare multicentre randomized controlled study. Between November 2009 January 2014, 73 patients were...
Background To determine the prevalence of main inspiratory asynchrony events during non-invasive intermittent positive-pressure ventilation (NIV) for severe bronchiolitis. Ventilator response time and were compared in neurally adjusted ventilator assist (NAVA) pressure assist/control (PAC) modes. Methods This prospective physiological study was performed a university hospital's paediatric intensive care unit included 11 children (aged 35.2 ± 23 days) with respiratory syncytial virus...
Abstract Background Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia hyperleukocytosis up to 50 G/l, leading multiple organ failure death in 75% of cases. Leukodepletion may improve prognosis. A therapeutic strategy based on leukodepletion extracorporeal life support (ECLS) according different thresholds leucocytes has been proposed Rowlands colleagues. We aimed at identifying factors associated with assess whether the respect...
Abstract Introduction High‐flow nasal cannula (HFNC) is commonly used as first step respiratory support in infants with moderate‐to‐severe acute viral bronchiolitis (AVB). This device, however, fails to effectively manage distress about a third of patients, and data are limited on determinants patient response. The rate–oxygenation (ROX) index relevant tool predict the risk for HFNC failure adult patients lower tract infections. primary objective this study was assess relationship between...
Intracranial Hypertension (ICH) is a life-threatening complication of brain injury. The invasive measurement intracranial pressure (ICP) remains the gold standard to diagnose ICH. Measurement Optic Nerve Sheath Diameter (ONSD) using ultrasonography non-invasive method for detecting However, data on paediatric injury are scarce. aim study was determine performance initial ONSD predict ICH occurring in children with severe and describe values control group.In this cross-sectional study,...
Introduction High flow nasal cannula (HFNC) is commonly used as first step respiratory support in infants with moderate-to-severe acute viral bronchiolitis (AVB). This device, however, fails to effectively manage distress about a third of patients, and data are limited on determinants patient response. The rate-oxygenation (ROX) index relevant tool predict the risk for HFNC failure adult patients lower tract infections. primary objective this study was assess relationship between ROX indexes...
La ventilation non invasive (VNI) est devenue le support ventilatoire de première intention en service réanimation pédiatrique. Le succès la technique repose sur des interfaces adaptées à morphologie l'enfant et gestion fuites, ce qui représentent une charge travail paramédicale (et médicale) importante mais indispensable. choix l'interface, masque facial ou classiques (nasales notamment) essentiel pour diminuer les fuites améliorer synchronisation particulièrement chez nourrisson. Les modes...