A5009245286- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory and Cough-Related Research
- COVID-19 Impact on Reproduction
- Viral gastroenteritis research and epidemiology
- Mechanical Circulatory Support Devices
- Influenza Virus Research Studies
- Vasculitis and related conditions
- Streptococcal Infections and Treatments
- Hemoglobinopathies and Related Disorders
- Coronary Artery Anomalies
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Antibiotic Resistance in Bacteria
- COVID-19 and healthcare impacts
- Antibiotic Use and Resistance
- Tracheal and airway disorders
- Adolescent and Pediatric Healthcare
- Child and Adolescent Health
Hôpital Robert-Debré
2016-2025
Inserm
2017-2025
Université Paris Cité
2017-2025
Infection, Anti-microbiens, Modélisation, Evolution
2023-2025
Centre Hospitalier Universitaire Sainte-Justine
2022-2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2018-2025
Evaluation et recherche en services et politiques en santé pour les populations vulnérables
2017-2025
Assistance Publique – Hôpitaux de Paris
2018-2025
Sorbonne Paris Cité
2018-2025
Société Française de Cardiologie
2020-2024
Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase number of children presenting to hospitals greater Paris region phenotype resembling Kawasaki disease (KD) has led alert by French national health authorities. Multicentre compilation patients KD since April 2020, associated detection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('Kawa-COVID-19'). A historical cohort 'classical' served as...
<h3>Importance</h3> Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with acute respiratory coronavirus 2 infection, potentially life-threatening, but optimal therapeutic strategy remains unknown. <h3>Objective</h3> To compare intravenous immunoglobulins (IVIG) plus methylprednisolone vs IVIG alone as initial therapy MIS-C. <h3>Design, Setting, and Participants</h3> Retrospective cohort study drawn from a national surveillance system...
Abstract A time series analysis of 871 543 pediatric emergency visits revealed that the coronavirus disease 2019 (COVID-19) lockdown and school closures were associated with a significant decrease in infectious diseases disseminated through airborne or fecal–oral transmission: common cold, gastroenteritis, bronchiolitis, acute otitis. No change was found for urinary tract infections.
<h3>Importance</h3> An association between pneumococcal nasopharyngeal carriage and invasive disease (IPD) has been previously established. However, it is unclear whether the decrease in IPD incidence observed after implementation of nonpharmaceutical interventions (NPIs) during COVID-19 pandemic was associated with concomitant changes respiratory viral infections. <h3>Objective</h3> To assess NPIs examine their temporal rate infections (specifically syncytial virus [RSV] influenza cases)...
In a 15-year pediatric time-series analysis, we showed rise of invasive Group A streptococcal (iGAS) infections since October 2022, mainly involving pleural empyema, simultaneously to respiratory virus outbreak. Physicians should be aware this increased risk iGAS infections, especially in settings with intense viruses' circulation.
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis, resulting in 3 million hospitalizations each year worldwide. Nirsevimab a monoclonal antibody against RSV that has an extended half-life. Its postlicensure real-world effectiveness RSV-associated bronchiolitis unclear.
Initial reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in children suggested that very young age and comorbidities may increase risk of evolution, but these findings remained to be confirmed. We aimed analyze the clinical spectrum hospitalized pediatric SARS-CoV-2 infection predictors disease evolution. conducted a French national prospective surveillance with infection. included all confirmed 60 hospitals during February 15 June 1, 2020. The main outcome...
Abstract To assess the relevance of systematic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening all children admitted to hospital, we conducted a prospective multicenter study including 438 consecutive hospitalized children. A symptom-based SARS-CoV-2 testing strategy failed identify 45% (95% confidence interval, 24%–68%) infected by SARS-CoV-2. limit intrahospital transmission, hospital should be considered.
Covid-19 pandemic control has imposed several non-pharmaceutical interventions (NPIs). Strict application of these measures had a dramatic reduction on the epidemiology infectious diseases. As is ongoing for more than 2 years, some have been removed, mitigated, or less well applied. The aim this study to investigate trends pediatric ambulatory diseases before and up two years after onset pandemic.We conducted prospective surveillance in France with 107 pediatricians specifically trained From...
Multisystem inflammatory syndrome in children (MIS-C) is the most severe clinical entity associated with pediatric SARS-CoV-2 infection a putative role of spike protein into immune system activation. Whether COVID-19 mRNA vaccine can induce this complication unknown. We aimed to assess risk hyper-inflammatory following children.
Respiratory viruses have been previously suspected to trigger invasive pneumococcal disease (IPD). After progressive non-pharmaceutical interventions (NPI) lifting, an unusual RSV outbreak has observed in the Fall 2021, raising concerns about possible consequences on IPD. We aimed analyse evolution of IPD incidence across age-groups since NPI and its temporal association with respiratory viral infections.We conducted a time-series analysis using 1) population-based surveillance data 2)...
Respiratory syncytial virus (RSV) is the leading cause of lower-respiratory-tract infection in children. Nirsevimab, a monoclonal antibody against RSV, was implemented few countries September 2023. However, its post-license effectiveness ambulatory care settings unknown. We aimed to assess nirsevimab RSV-bronchiolitis outpatients aged <12 months.
Importance Henoch-Schönlein purpura (HSP) is the most common type of vasculitis in children. The factors that trigger disease are poorly understood. Although several viruses and seasonal bacterial infections have been associated with HSP, differentiating specific associations these pathogens onset HSP remains a challenge due to their overlapping patterns. Objective To analyze role epidemiology HSP. Design, Setting, Participants This cohort study comprised an interrupted time-series analysis...
Epidemiological surveillance of nasopharyngeal pneumococcal carriage is important for monitoring serotype distribution and antibiotic resistance, particularly before after the implementation conjugate vaccines (PCVs). With a prospective study in France, we aimed to analyze dynamics carriage, susceptibility children aged 6 24 months who had acute otitis media between 2001 2022 with focus on late PCV13 period from May 2014 July 2022. Trends were analyzed segmented linear regression...
After the implementation of nirsevimab in 2023 France as compared with 2022–2023, we found a 52.7%, (95% CI [46.4–58.9])decrease all-cause bronchiolitis children &lt;3 months lowest number cases this population since 2017.
Importance Numerous studies have provided evidence for the negative associations of COVID-19 pandemic with mental health, but data on use psychotropic medication in children and adolescents after onset are lacking. Objective To assess rates trends prescribing before over 2 years France. Design, Setting, Participants This cross-sectional study used nationwide interrupted time-series analysis outpatient drug dispensing from IQVIA X-ponent database. All 8 839 143 prescriptions dispensed to (6...
Many antibiotics are prescribed inappropriately in pediatric emergency departments (PEDs), but little data available these settings about effective interventions based on guidelines that follow the antimicrobial stewardship principle. Our aim was to assess impact of implementing 2011 national antibiotic prescriptions for acute respiratory tract infection (ARTI) PEDs.We conducted a multicentric, quasiexperimental, interrupted time series analysis prospectively collected electronic from 7...
Abstract We aimed to assess the invasive disease potential of non-PCV13 serotypes after implementation this vaccine. Most had low potential. Among with highest (12F, 24F, 38, 8, 33F, 22F, and 10A), all but 24F 38 were included in PCV20.