A5003601764- Gut microbiota and health
- Cardiac Arrest and Resuscitation
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Ruminant Nutrition and Digestive Physiology
- Pelvic floor disorders treatments
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Urinary Tract Infections Management
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Calcium signaling and nucleotide metabolism
- COVID-19 Impact on Reproduction
- Thermal Regulation in Medicine
- Reproductive tract infections research
- Healthcare Policy and Management
- HIV, Drug Use, Sexual Risk
- Effects of Environmental Stressors on Livestock
- Plant and fungal interactions
- Child Abuse and Related Trauma
- Neurosurgical Procedures and Complications
Institut Pasteur de Lille
2023-2025
Paris Biotech Santé
2024
Centre Hospitalier Sud-Essonne Dourdan-Etampes
2020
Inserm
2000-2014
Université Paris-Sud
2014
Bicêtre Hospital
2014
Assistance Publique – Hôpitaux de Paris
2005-2014
Centre de recherche en Epidémiologie et Santé des Populations
2014
Hôpital Necker-Enfants Malades
2001-2010
Hôpital Armand-Trousseau
2005
To describe the results of an integrated pre- and in-hospital approach to critical care in a large population children with severe traumatic brain injury identify early predictors their outcome.A 9-yr retrospective review data trauma bank.Level III pediatric center.All (1 month 15 yrs) (Glasgow Coma Scale </=8) hospitalized our center followed until death or for >/=6 months after discharge.None.Univariate further multivariate analyses were performed determine independent predictive factors...
Initial reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in children suggested that very young age and comorbidities may increase risk of evolution, but these findings remained to be confirmed. We aimed analyze the clinical spectrum hospitalized pediatric SARS-CoV-2 infection predictors disease evolution. conducted a French national prospective surveillance with infection. included all confirmed 60 hospitals during February 15 June 1, 2020. The main outcome...
Enteroviruses are the most frequent cause of acute meningitis and seen increasingly in sepsis-like disease fever without source paediatric population. Detection enterovirus cerebrospinal fluid (CSF) specimens by PCR is gold standard diagnostic test. Our aim was to assess a method detecting blood PCR.We did prospective, multicentre, observational study at 35 French emergency departments 16 hospitals. We recruited newborn babies (aged ≤28 days) infants >28 days ≤2 years) with source, disease,...
Abstract: Poly(ADP‐ribose) synthase (PARS), an abundant nuclear protein, has been described as important candidate for mediation of neurotoxicity by nitric oxide. However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation neuronal damage. We examined the effect inhibiting on (a) degree injury, (b) process inflammatory responses, (c) functional outcomes a neonatal rat model focal ischemia. demonstrate that administration 3‐aminobenzamide, inhibitor,...
The population structure of extraintestinal pathogenic Escherichia coli evolves over time, notably due to the emergence antibiotic-resistant clones such as ESBL-producing Enterobacteriaceae (ESBL-E).To analyse by WGS genetic diversity a large number ESBL-E isolated from urinary tract infections in children paediatric centres across France between 2014 and 2017 collected National Observatory febrile infection (FUTI) caused ESBL-E.A total 40 905 Enterobacteriaceae-positive urine cultures were...
Understanding the clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and prognosis in children is a major issue. Children often present mild symptoms, some forms require paediatric intensive care, with cases fatal prognosis. Our aim was to identify epidemiological characteristics, presentation, disease 2019 (Covid-19) hospitalized Paris suburb hospitals. In this prospective, observational, multicentre study, we included departments hospitals from...
In recent decades, the digestive tract microbiota of livestock has been extensively studied, revealing associations with host phenotypes, including production- and health-related traits. The effect genetics on gut microbes documented in several species; however, dairy cattle, specific genomic regions that influence microbial communities remain relatively unexplored. This study aimed to conduct a sequence-based GWAS gene-based association identify candidate genes affecting fecal diversity...
Due to their potential impact on the host's phenotype, organ-specific microbiotas are receiving increasing attention in several animal species, including cattle. Specifically, vaginal microbiota of ruminants is attracting growing interest, due its predicted critical role cows' reproductive functions livestock contexts. Notably, fertility disorders represent a leading cause for culling, and additional research would help fill relevant knowledge gaps. In present study, we aimed characterize...
The performance of dairy cows is influenced by the microbial communities hosted within their digestive tract. While rumen microbiota has long been associated with host phenotypes, impact faecal remains elusive. In this study, we collected 697 samples from commercial Holstein and analysed them 16S rRNA gene analyses. For each animal, routinely recorded data, i.e., milk yield, fat protein content, an aggregate production trait (pINEL) based on French economic index, were available to assess...
During the 2009 H1N1 influenza pandemics, concentrations of oseltamivir (O) and its active metabolite (oseltamivir carboxylate [OC]) were determined in 11 children (1 month to 16 years age) admitted intensive care units for presumed severe infection. They received phosphate (OP) nasogastrically at doses between 1.5 6.8 mg/kg body weight. High OC found, with a mean level 678 ± 535 μg/liter. The OP concentration was 27 52 No marked side effect reported.
Oral treatment of febrile urinary tract infections (FUTIs) can be impaired by MDR Enterobacterales often combining ESBL and inhibitor-resistant genes. We studied the impact β-lactamases Enterobacterales' genotypes on cefixime, cefpodoxime mecillinam ± amoxicillin/clavulanate MICs.In this multicentric study, we included 251 previously whole-genome-sequenced ESBL-producing Enterobacterales, isolated in French children with FUTIs. The MICs cefpodoxime, alone combined were determined analysed...
Abstract Background Because of its potential influence on the host’s phenotype, increasing attention is paid to organ-specific microbiota in several animal species, including cattle. However, ecosystems other than those related digestive tract remain largely understudied. In particular, little known about vaginal ruminants despite importance reproductive functions cows a livestock context, where fertility disorders represent one primary reasons for culling. Results present study, we aimed at...
A new adjunctive system to obtain higher PaO 2 with nasal cannula or catheter: double trunk mask
Background: Understanding the clinical presentation of SARS-CoV-2 infection and prognosis in children is a major issue. Children often present mild symptoms, some severe forms require paediatric intensive care, with cases fatal prognosis. Our aim was to identify epidemiological characteristics, coronavirus disease 2019 (Covid-19) hospitalized Paris suburb hospitals. Methods: In this prospective, observational, multicentre study, we included one 23 departments hospitals from March May 10,...