A5028207329- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Fatty Acid Research and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Radiopharmaceutical Chemistry and Applications
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- S100 Proteins and Annexins
- Neonatal Respiratory Health Research
- Synthesis and Biological Evaluation
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Metabolism and Genetic Disorders
- Neuroendocrine regulation and behavior
Université de Tours
2014-2024
Inserm
2014-2024
Imagerie et Cerveau
2009-2019
Vita-Salute San Raffaele University
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019
University of Münster
2019
Johanniter-Krankenhaus Bonn
2019
Université de Poitiers
2015
NYU Langone Health
2015
The concept of a threshold dopamine (DA) depletion for onset Parkinson's disease symptoms, although widely accepted, has, to date, not been determined experimentally in nonhuman primates which more rigorous definition the mechanisms responsible effect might be obtained. present study was thus designed determine (1) relationship between Parkinsonian symptom appearance and level degeneration nigrostriatal pathway (2) concomitant presynaptic postsynaptic striatal response denervation, monkeys...
Abstract: The effects of α‐linolenic acid diet deficiency on rat dopaminergic and serotoninergic neurotransmission systems were investigated in the frontal cortex, striatum, cerebellum male rats 2, 6, 12, 24 months age. induced a severe decrease 22:6n‐3 fatty levels all regions compensatory increase n‐6 levels. A recovery was observed deficient between 2 12 age; however, this lower cortex than striatum cerebellum. In cerebellum, receptor densities endogenous dopamine serotonin affected by...
The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor, is dramatically upregulated under pathologic conditions. Activated microglia are main cell type expressing TSPO at sites of central nervous system pathology. Radioligands for can therefore measure active disease in brain. This article details synthesis, radiofluorination, and pharmacologic evaluation a new TSPO-specific pyrazolopyrimidine, DPA-714. <b>Methods:</b> affinity DPA-714 was measured...
We explored the effects of chronic alpha-linolenic acid dietary deficiency on serotoninergic neurotransmission. In vivo synaptic serotonin (5-HT) levels were studied in basal and pharmacologically stimulated conditions using intracerebral microdialysis hippocampus awake 2-month-old rats. also reversion deficient diet fatty composition A balanced (control) was supplied to rats at different stages development, i.e. from birth, 7, 14 or 21 days age. demonstrated that n-3 polyunsaturated induced...
We studied the effects of a diet chronically deficient in α-linolenic acid, precursor long-chain n–3 polyunsaturated fatty acids, on dopaminergic neurotransmission shell region nucleus accumbens rats. In vivo microdialysis experiments showed increased basal levels dopamine and decreased metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) homovanillic (HVA), awake rats from group compared to controls. The release under KCl stimulation was similar both dietary groups. By contrast, vesicular...
Maternal infection/inflammation represents one of the most important factors involved in etiology brain injury newborns. We investigated modulating effect prenatal melatonin on neonatal inflammation process resulting from maternal intraperitoneal (i.p.) lipopolysaccharide (LPS) injections. LPS (300 μg/kg) was administered to pregnant rats at gestational days 19 and 20. Melatonin (5 mg/kg) i.p. same time as LPS. counteracted sensitization a second ibotenate-induced excitotoxic insult...
at the Aβ plaques locations, while NeuN labelling revealed an age-dependent decrease in hippocampal neuron number both genotypes.Behavioural assessment using novel object recognition task that WT & TgF344-AD animals discriminated from familiar 3 m and 6 of age.However, low levels exploration observed genotypes later time-points resulted neither genotype successfully completing task.Deficits social interaction were only animals.By vivo MRS, we showed a neuronal marker N-acetyl-aspartate...
Because brain membranes contain large amounts of docosahexaenoic acid (DHA, 22:6n-3), and as (n-3) PUFA dietary deficiency can lead to impaired attention, learning, memory performance in rodents, we have examined the influence an PUFA-deprived diet on central cholinergic neurotransmission system. We focused several neurochemical parameters frontal cortex hippocampus rats fed PUFA-deficient diet, compared with a control diet. The resulted changes membrane phospholipid compositions both...
Previous investigations have shown that the lipid composition of cerebral membranes and dopaminergic neurotransmission are changed under chronic α-linolenic acid diet deficiency in rat. This study investigated whether these changes could be reversed if stage brain maturation might play a role recovery process. The effects reversion on fatty (FA) were studied regions known to affected by such (i.e., prefrontal cortex nucleus accumbens) 2-month-old animals. Dopamine release pharmacological...
Two novel series of iodinated N-substituted analogs 2β-carbomethoxy-3β-(4'-iodophenyl)tropane (β-CIT) and N-(3-iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3',4'-disubstituted phenyl)nortropane were synthesized. They evaluated for their inhibitory properties on dopamine (DAT), serotonin (5-HTT), norepinephrine (NET) transporters in rat brain homogenates using [3H]GBR-12935, [3H]paroxetine, [3H]nisoxetine as specific ligands. All new β-CIT exhibited higher DAT selectivity over both 5-HTT NET than...
The aim of this study was to examine the effects supplementation with n-3 polyunsaturated fatty acids (PUFAs) on stress responses in mice subjected an unpredictable chronic mild (UCMS) procedure. Stress-induced modifications coat and aggressiveness were evaluated, phospholipid PUFA profiles monoamine levels analyzed frontal cortex, hippocampus, striatum. results showed that repeated exposure stressors induced degradation physical state coat, lowered body weight gain, increased...