A5026443924- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Gut microbiota and health
- Parasitic infections in humans and animals
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Animal Behavior and Welfare Studies
- Effects of Environmental Stressors on Livestock
- Clostridium difficile and Clostridium perfringens research
- Evolutionary Algorithms and Applications
- COVID-19 Clinical Research Studies
- Probiotics and Fermented Foods
- Food Supply Chain Traceability
- Genetic Mapping and Diversity in Plants and Animals
- Advanced Biosensing Techniques and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Molecular Biology Techniques and Applications
- SARS-CoV-2 detection and testing
- Ruminant Nutrition and Digestive Physiology
- Milk Quality and Mastitis in Dairy Cows
- Research Data Management Practices
- Bioactive Compounds and Antitumor Agents
- Healthcare Systems and Practices
- Animal testing and alternatives
Institut Pasteur de Lille
2019-2025
Paris Biotech Santé
2022-2024
State Key Laboratory of Oncogene and Related Genes
2011-2022
Centre Hospitalier de Douai
2012-2021
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2014-2020
Laboratoire de Biométrie et Biologie Evolutive
2020
Groupe des Écoles Nationales d'Économie et Statistique
2014-2017
Inserm
2009
Laboratoire d'Informatique Fondamentale de Lille
2009
University of Milano-Bicocca
2007
Abstract Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such inflammatory bowel disease and irritable syndrome, or infections by diverse enteric pathogens. Blastocystis is one most common single-celled eukaryotes detected human faecal samples. However, clinical significance this widespread colonization remains unclear, its pathogenic potential controversial. To address issue pathogenicity,...
Blastocystis sp. is an enteric protozoan that frequently colonizes humans and many animals. Despite impacting on human health, data the prevalence subtype (ST) distribution of remain sparse in Africa. Accordingly, we performed first multicenter largest epidemiological survey ever conducted for this continent. A total 731 stool samples collected from healthy school children living 10 villages northwestern region Senegal were tested presence by real-time polymerase chain reaction followed...
Although Blastocystis sp. is the most common enteric protozoan in human stools worldwide, various geographical areas remain to be investigated regarding frequency and circulation of this parasite. Such case some developing countries Southeast Asia that exhibit a higher risk for parasitic infections due unsanitary conditions. While several epidemiological surveys have been conducted, instance, Thailand, little or no data are available from neighboring countries, such as Vietnam. Therefore,...
The association between Cryptosporidium and human colon cancer has been reported in different populations. However, this not well studied. In order to add new strong arguments for a probable link cryptosporidiosis cancer, the aim of study was determine prevalence identify species among Lebanese patients.Overall, 218 digestive biopsies were collected Tripoli, Lebanon, from three groups patients: (i) patients with recently diagnosed intraepithelial neoplasia/adenocarcinoma before any treatment...
Human gut microbial communities are mainly composed of bacteria, but also include fungi, viruses, archaea, and protozoa, whose role in the ecosystem has only recently begun to be recognized. For example, humans colonized by Blastocystis (a protozoan with controversial pathogenicity) host a more diverse bacterial microbiota than individuals not carrying it, suggesting that its presence may beneficial for host. In parallel, non-pathogenic Entamoeba spp. been associated an increased diversity...
Given the proven zoonotic potential of intestinal protozoan
Blastocystis sp. is the most common single-celled eukaryote colonizing human gastrointestinal tract worldwide. Because of proven zoonotic potential this protozoan, sustained research therefore focused on identifying various reservoirs transmission to humans, and in particular animal sources. Numerous groups animals are considered be such due their handling or consumption. However, some them, including mollusks, remain underexplored. Therefore, a molecular epidemiological survey conducted...
Cryptosporidium, a zoonotic pathogen, is able to infect wide range of hosts including wild and domestic animals, humans. Although it well known that some parasites are both fish pathogens recognized agents zoonosis with public health impact, little information available concerning the prevalence Cryptosporidium in aquatic environments. To evaluate spp. commercially important edible marine different European seas (English channel, North sea, Bay Biscay, Celtic sea Mediterranean sea), 1,853...
Blastocystis sp. is a widespread enteric protozoan that frequently infects human and animal groups. Despite its burden zoonotic potential worldwide, epidemiological investigations remain limited in groups come contact with humans. Therefore, the largest survey ever conducted North Africa was performed Egypt aim to investigate prevalence subtype (ST) distribution of animals. For this purpose, total 889 fecal specimens were collected from chickens (217), cattle (373), dogs (144) cats (155) six...
Blastocystis sp. is currently reported as the most frequent single-celled eukaryote inhabiting intestinal tract of humans and a wide range animal groups. Its prevalence especially higher in developing countries linked with fecal peril. Despite growing interest this enteric protozoan, certain geographical regions potentially at high risk infection, such North Africa, remain under-investigated. Therefore, large-scale molecular epidemiological survey, including 825 participants presenting...
Gut commensal bacteria are known to have a significant role in regulating the innate and adaptive immune homeostasis. Alterations intestinal microbial composition been associated with several disease states, including autoimmune inflammatory conditions. However, it is not entirely clear how gut microbiota modulate contribute systemic immunity, whether circulating elements of host system could regulate microbiome. Thus, we studied diversity abundance specific taxons inbred GalT-KO mice during...
Molecular data concerning the prevalence and subtype (ST) distribution of intestinal parasite Blastocystis sp. remain scarce in Middle East. Accordingly, we performed first molecular epidemiological survey ever conducted Syrian population. A total 306 stool samples were collected from refugees living 26 informal tented settlements (ITS) subjected or not to water, sanitation, hygiene (WASH) interventions North Lebanon, then screened for presence by real-time polymerase chain reaction followed...
In recent decades, the digestive tract microbiota of livestock has been extensively studied, revealing associations with host phenotypes, including production- and health-related traits. The effect genetics on gut microbes documented in several species; however, dairy cattle, specific genomic regions that influence microbial communities remain relatively unexplored. This study aimed to conduct a sequence-based GWAS gene-based association identify candidate genes affecting fecal diversity...
Targeted metagenomics is the solution of choice to reveal differential microbial profiles (defined by richness, diversity and composition) as part case-control studies. It well documented that each data processing step may have potential introduce bias in results. However, selecting a bioinformatics pipeline analyze high-throughput sequencing from A Z remains one critical considerations microbiota study design. Consequently, aim this was assess whether same biological conclusions regarding...
Blastocystis sp. is a single-celled parasite estimated to colonize the digestive tract of 1 2 billion people worldwide. Although it represents most frequent intestinal protozoa in human stools, remains still under-investigated countries with high risk infection due poor sanitary and hygiene conditions, such as Africa. Therefore, present study was carried out determine prevalence subtype (ST) distribution Guinean population. For this purpose, fecal samples were collected from 500 individuals...
Cryptosporidium apicomplexan protozoa are ubiquitous intracellular agents affecting humans and animals. In particular, bovine cryptosporidiosis is recognized as endemic worldwide. However, epidemiological investigations remain limited in France regarding the burden of these parasites cattle. To improve our understanding epidemiology cryptosporidiosis, main aim this study was to determine frequency genetic diversity adult Prim’Holstein dairy cattle farms north France. Fecal specimens were...
The performance of dairy cows is influenced by the microbial communities hosted within their digestive tract. While rumen microbiota has long been associated with host phenotypes, impact faecal remains elusive. In this study, we collected 697 samples from commercial Holstein and analysed them 16S rRNA gene analyses. For each animal, routinely recorded data, i.e., milk yield, fat protein content, an aggregate production trait (pINEL) based on French economic index, were available to assess...
The increase in available sequence data has advanced the field of microbiology; however, making sense these without bioinformatics skills is still problematic. We describe MICRA, an automatic pipeline, as a web interface, for microbial identification and characterization through reads analysis. MICRA uses iterative mapping against reference genomes to identify genes variations. Additional modules allow prediction antibiotic susceptibility resistance comparing results several samples. fast,...
Abstract In the past decade, metagenomics studies have become widespread due to arrival of second-generation sequencing platforms characterized by low costs, high throughput and short read lengths. Today, although benchtop sequencers are considered be accurate deliver data for targeted studies, limiting factor has analysis these data. a previous paper, we performed an Ion Torrent PGM 16S rDNA gene faecal DNAs from 48 Blastocystis -colonized patients -negative subjects, in order decipher...
Cryptosporidium parvum is a leading cause of diarrhoeal illness worldwide being significant threat to young children and immunocompromised patients, but the pathogenesis caused by this parasite remains poorly understood. C. was recently linked with oncogenesis. Notably, mechanisms gene expression regulation are unexplored in little known about how impact host genome regulation. Here, we investigated potential histone lysine methylation, dynamic epigenetic modification, during life cycle...
Gene expression databases are key resources for microarray data management and analysis the importance of a proper annotation their content is well understood. Public repositories as database systems that can be implemented by single laboratories exist. However, there not yet tool easily support collaborative environment where different users with rights access to interact define common highly coherent content. The scope Genopolis provide resource allows groups performing experiments related...