A5066160974- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Escherichia coli research studies
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Influenza Virus Research Studies
- Respiratory Support and Mechanisms
- Urinary Tract Infections Management
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Emergency and Acute Care Studies
- Enterobacteriaceae and Cronobacter Research
- Kawasaki Disease and Coronary Complications
- Otolaryngology and Infectious Diseases
- Hepatitis Viruses Studies and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Pediatric Urology and Nephrology Studies
Association Clinique et Thérapeutique Infantile du Val de Marne
2016-2025
Association Française de Pédiatrie Ambulatoire
2021-2025
Institut Mondor de Recherche Biomédicale
2017-2025
Université Paris-Est Créteil
2025
Hôpital Intercommunal de Créteil
2012-2022
Assistance Publique – Hôpitaux de Paris
2015-2021
Université Paris Cité
2015-2021
Hôpital Robert-Debré
2015-2021
Inserm
2021
Evaluation et recherche en services et politiques en santé pour les populations vulnérables
2021
<h3>Importance</h3> An association between pneumococcal nasopharyngeal carriage and invasive disease (IPD) has been previously established. However, it is unclear whether the decrease in IPD incidence observed after implementation of nonpharmaceutical interventions (NPIs) during COVID-19 pandemic was associated with concomitant changes respiratory viral infections. <h3>Objective</h3> To assess NPIs examine their temporal rate infections (specifically syncytial virus [RSV] influenza cases)...
Initial reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in children suggested that very young age and comorbidities may increase risk of evolution, but these findings remained to be confirmed. We aimed analyze the clinical spectrum hospitalized pediatric SARS-CoV-2 infection predictors disease evolution. conducted a French national prospective surveillance with infection. included all confirmed 60 hospitals during February 15 June 1, 2020. The main outcome...
Covid-19 pandemic control has imposed several non-pharmaceutical interventions (NPIs). Strict application of these measures had a dramatic reduction on the epidemiology infectious diseases. As is ongoing for more than 2 years, some have been removed, mitigated, or less well applied. The aim this study to investigate trends pediatric ambulatory diseases before and up two years after onset pandemic.We conducted prospective surveillance in France with 107 pediatricians specifically trained From...
Respiratory syncytial virus (RSV) is the leading cause of lower-respiratory-tract infection in children. Nirsevimab, a monoclonal antibody against RSV, was implemented few countries September 2023. However, its post-license effectiveness ambulatory care settings unknown. We aimed to assess nirsevimab RSV-bronchiolitis outpatients aged <12 months.
To the Editors: We read with interest article by Kaur et al1 which anticipated effects of higher-valency pneumococcal vaccines (PCVs; PCV15 and PCV20) on colonization acute otitis media (AOM). The authors found that most Streptococcus pneumoniae (Sp) isolates among young children were non-PCV15, non-PCV20 serotypes, especially serotype 35B. Therefore, they concluded impact PCVs reducing or AOM is expected to be limited in Rochester, New York. would like complement their results data from...
Changes in serotype distribution have been induced after pneumococcal conjugate vaccines (PCV) implementation, and non-vaccine serotypes are now circulating. Among these latter serotypes, we aimed to distinguish those with high invasive disease potential before (2008-2009) PCV13 implementation (2012-2013).Invasive (IPD) isolated from children 6 24 months were compared nasopharyngeal-colonizing healthy children. To assess the of a given serotype, odds ratios (ORs) calculated. For each OR >1...
Background. We aimed to describe features of Escherichia coli meningitis in a large population children and the molecular characteristics involved strains determine factors associated with severe disease or death.
Abstract We aimed to assess the invasive disease potential of non-PCV13 serotypes after implementation this vaccine. Most had low potential. Among with highest (12F, 24F, 38, 8, 33F, 22F, and 10A), all but 24F 38 were included in PCV20.
BackgroundInterventions to mitigate the COVID-19 pandemic may impact other respiratory diseases.AimsWe aimed study course of pertussis in France over an 8-year period including beginning and its association with mitigation strategies, using multiple nationwide data sources regression models.MethodsWe analysed number French cases between 2013 2020, PCR test results from outpatient laboratories (Source 1) a network paediatric wards 41 hospitals 2). We also used reports national primary care...
Epidemiological surveillance of nasopharyngeal pneumococcal carriage is important for monitoring serotype distribution and antibiotic resistance, particularly before after the implementation conjugate vaccines (PCVs). With a prospective study in France, we aimed to analyze dynamics carriage, susceptibility children aged 6 24 months who had acute otitis media between 2001 2022 with focus on late PCV13 period from May 2014 July 2022. Trends were analyzed segmented linear regression...
In children, respiratory infections such as SARS-CoV-2, syncytial virus (RSV), and influenza share similar clinical signs symptoms. Here we compared the performance of a rapid antigen diagnostic test using self-collected anterior nasal swab (COVID-VIRO ALL IN TRIPLEX) multiplex RT-PCR.From October to December 2022, in emergency pediatrics unit Orleans Hospital, France, evaluated accuracy triplex test.For 263 sensitivity was 88.9% (95%CI 51.8-99.7), 79.1% 64.0-90.0), 91.6% 84.1-96.3), for...
After the implementation of nirsevimab in 2023 France as compared with 2022–2023, we found a 52.7%, (95% CI [46.4–58.9])decrease all-cause bronchiolitis children &lt;3 months lowest number cases this population since 2017.
No AccessJournal of UrologyAdult Urology1 Apr 2009Molecular Analyte Profiling the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder Canceris accompanied byIncreased Infiltration Tumor Associated Macrophages is Poor Prognosis Carcinoma In Situ After InstillationPrevention Treatment Transitional Cell Carcinomatosis Intraperitoneal Chemotherapy a Rat Model Aurélie Bisiaux, Nicolas Thiounn, Marc-Olivier Timsit, Ahmed...
Streptococcus pneumoniae remains an important cause of bacterial meningitis in children younger than 2 years. Here, we analyzed data from active surveillance network established 12 years ago by the Pediatric Infectious Disease Group and Clinical Therapeutical Association to analyze impact pneumococcal conjugate vaccine (PCV7 implemented 2002 PCV13 2010) on (PM).Two hundred twenty-seven pediatric wards working with 168 microbiology departments throughout France were asked report all cases...
Objectives To assess the management of febrile urinary-tract infection (FUTIs) due to extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E) in children, Pediatric Infectious Diseases Group French Society set up an active surveillance network pediatric centers across France 2014. Materials and methods We prospectively analysed data from 2014 2016 for all children < 18 years old who received antibiotic treatment FUTI ESBL-E 24 centers. Baseline demographic, clinical features,...
Group B Streptococcus (GBS) disease is the leading cause of neonatal bacterial meningitis despite women receiving an intravenous antibiotic prophylaxis during labor. We aimed to describe GBS in children <1 year old France.Clinical and biological data gathered by Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV) were analyzed. The cases classified age: 0-6 days (early-onset [EOD]), newborns infants 7-89 (late-onset [LOD]: LOD1, 7-26 days; LOD2, 27-89 days), aged 3 months...
The objective of this study was to evaluate the evolution and risk factors ESBL-producing Enterobacteriaceae (ESBL-E) carriage in children community for a long period distinguishing ST131 non-ST131 Escherichia coli.In prospective study, rectal samples were obtained from aged 6-24 months by paediatricians between 2010 2015. Demographic characteristics ESBL-E collected. Distribution β-lactamase genes, phylogenetic groups, virulence resistant E. coli determined.We enrolled 1886 children; 144...
<h3>Importance</h3> In several countries, 5 years after 13-valent pneumococcal conjugate vaccine (PCV13) implementation, serotype replacement has been reported for invasive disease, which raises concerns about the long-term outcome of PCV13 implementation. The effect vaccination on community-acquired pneumonia (CAP) remains unknown. <h3>Objective</h3> To assess implementation CAP in children. <h3>Design, Setting, and Participants</h3> This quasi-experimental, population-based, interrupted...
Pneumococcal conjugate vaccine (PCV) implementation has led to a sharp decrease in invasive pneumococcal disease (IPD) due the reduction PCV serotypes. We aimed describe changes spectrum of IPD and its clinical presentations after 13-valent (PCV13) implementation. This prospective, hospital-based, active surveillance involved 130 pediatric wards microbiology departments throughout France. analyzed cases from 2011 2016 for which isolate was sent National Reference Center Pneumococci...