A5024106221- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Eosinophilic Disorders and Syndromes
- Diabetes and associated disorders
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
- Coronary Artery Anomalies
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- IL-33, ST2, and ILC Pathways
- Dermatological and COVID-19 studies
- Infectious Diseases and Tuberculosis
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- Intestinal and Peritoneal Adhesions
- French Language Learning Methods
- Leprosy Research and Treatment
- Pediatric health and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Liver Diseases and Immunity
- Education, sociology, and vocational training
Hôpital Robert-Debré
2018-2025
Université Paris Cité
2021-2025
Assistance Publique – Hôpitaux de Paris
2018-2024
Centre de Recherche sur l'Inflammation
2023
Inserm
2023
Centre National pour la Recherche Scientifique et Technique (CNRST)
2023
Centre Hospitalier de Versailles
2019-2021
Université Lille Nord de France
2018
Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN immunity. We report a 5-yr-old child with severe at 2 yr. She is homozygous for loss-of-function IRF9 allele. Her cells activate gamma-activated factor (GAF) STAT1 homodimers but not IFN-stimulated gene 3 (ISGF3) trimers (STAT1/STAT2/IRF9) in response to IFN-α2b. The transcriptome induced IFN-α2b the patient's much narrower than that control cells; however, induction subset transcripts remains...
Importance Henoch-Schönlein purpura (HSP) is the most common type of vasculitis in children. The factors that trigger disease are poorly understood. Although several viruses and seasonal bacterial infections have been associated with HSP, differentiating specific associations these pathogens onset HSP remains a challenge due to their overlapping patterns. Objective To analyze role epidemiology HSP. Design, Setting, Participants This cohort study comprised an interrupted time-series analysis...
Kawasaki disease is an acute, febrile, systemic vasculitis of children that primarily affects medium-sized blood vessels with a tropism for the coronary arteries. Although etiological factors remain unknown, infections have been suggested as trigger disease. We sought to calculate fraction potentially attributable seasonal infections.This cohort study used population-based time series analysis from French hospitalisation database (Programme de Médicalisation des Systèmes d'Information),...
Abstract Objectives JDM and juvenile overlap myositis represent heterogeneous subtypes of idiopathic inflammatory myopathy (JIIM). Chronic evolution can occur in up to 60% cases, morbidity/mortality is substantial. We aimed describe the clinical, biological, histological type I IFN status JIIM associated with anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies at presentation (group 1) comparison other 2). Methods This was a retrospective prospective study patients...
Juvenile idiopathic arthritis is the most common chronic rheumatic disease in children, and its etiology remains poorly understood. Here, we explored four families with early-onset carrying homozygous loss-of-expression mutations LACC1. To understand link between LACC1 inflammation, performed a functional study of human immune cells. We showed that was primarily expressed macrophages upon mTOR signaling. found deficiency had no obvious impact on inflammasome activation, type I interferon...
Abstract Introduction Juvenile systemic lupus erythematosus (j-SLE) is a rare chronic autoimmune disease affecting multiple organs. Ranging from minor features, such as headache or mild cognitive impairment, to serious and life-threatening presentations, j-neuropsychiatric SLE (j-NPSLE) therapeutic challenge. Thus, the diagnosis of NPSLE remains difficult, especially in pediatrics, with no specific biomarker yet validated. Objectives To identify central nervous system (CNS) biomarkers...
The immune system is physiologically involved in brain development and homeostasis. Consequently, early immune-mediated events are known risk factors for neurodevelopmental disorders (NDD). We recently found that systemic autoimmune autoinflammatory (ESAID) associated with an increased of due to the direct impact inflammation on development. However not all ESAID patient will develop NDD. In this study, we aimed better characterized natural history NDD comorbidity investigate influence...
Objective Juvenile systemic lupus erythematosus (j-SLE) is a rare chronic auto-immune disease involving several organs. Neuropsychiatric (NP) SLE (NPSLE) frequent in j-SLE and associated with increased morbidity/mortality. Although NPSLE classification criteria exist, attributing NP features to remains major challenge. The study objective thoroughly describe j-NPSLE patients assist their diagnosis. Methods This 4-year retrospective monocentric of patients. events were attributed using...
ObjectiveTo examine whether the COVID-19 pandemic was associated with an increased incidence of uveitis in children.Study designWe performed a time-series analysis patient records from national, hospital-based, French surveillance system. All children hospitalized for France between January 2012 and March 2022 were included. The newly diagnosed per 100 000 trimester analyzed by quasi-Poisson regression. A cohort at Robert-Debré Hospital used to compare characteristics after before onset...
Neonatal hyperthyroidism may be caused by a permanent non-autoimmune genetic disorder or, more frequently, maternally transmitted high serum TRAb levels. Variable thyroid dysfunction observed in this second context. We aimed to evaluate the prevalence of neonatal and different types function neonates with risk due maternal Graves' disease (GD).This observational cohort study included all identified database single academic pediatric care center, over period 13 years, as having or an...
Early identification of high-risk patients is essential to stratify treatment algorithms Kawasaki disease (KD) and appropriately select at risk for complicated who would benefit from intensified first-line treatment. Several scores have been developed validated in Asian populations but shown low sensitivity predicting intravenous immunoglobulin (IVIG) resistance non-Asian populations. We sought methods predict the need secondary after initial IVIG populations.We conducted a retrospective,...
Glucocorticoid-induced adrenal insufficiency (GI-AI) is a common side effect of glucocorticoid therapy. However, its diagnosis currently relies on the realization Low Dose Short Synacthen Test (LD-SST) that requires an outpatient hospital and several blood samples. Our goal was to evaluate whether morning cortisol values could predict response LD-SST, in children, avoid useless dynamic tests facilitate induced insufficiency.We recorded data 91 pediatric patients who underwent LD-SST our...
Leprosy remains a public health concern in Mayotte, France, with prevalence of 3.11 per 10,000 inhabitants.1, 2 Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction which can complicate lepromatous leprosy (LL); both LL and ENL are uncommonly observed children.2, 3 Managing be difficult, some patients refractory to conventional therapies like corticosteroids thalidomide, necessitating exploration alternative treatments.4 We report the case teenage girl LL, suffering from...
Familial Mediterranean fever (FMF) is the most common hereditary systemic auto-inflammatory disease. Digestive complaint a feature during FMF attacks. Nevertheless, digestive in attack-free period has scarcely been studied. This retrospective monocentric study aimed to describe clinical, histological, and genetic features of pediatric patients with who underwent endo-colonoscopy this setting. Out 115 diagnosis FMF, 10 (8, 7%) endoscopy or colonoscopy. All displayed homozygote MEFV M694V...
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis in children and adolescents. Pharyngitis infections are known to be a trigger attacks. It has been suggested that IgAN an immune complex disease with circulating complexes galactose-deficient IgA1 (Gd-IgA1), IgG anti-Gd-IgA1 antibodies, soluble CD89. Amyloidosis renal complication Familial Mediterranean Fever (FMF), form auto-inflammatory syndromes characterized by flares fever polyserositis. Besides amyloidosis,...
Abstract This study was conducted to identify the contribution of myositis-specific antibodies (MSAs) on correlation between type I interferon (IFN-I) plasma levels and disease activity in juvenile dermatomyositis (JDM) patients. We prospectively obtained 198 samples from 49 JDM Autoantibody were determined for all Muscle scored using Childhood Myositis Assessment Scale (CMAS) Manual Testing 8 muscles (MMT-8) skin involvement with a Disease Activity Score (DAS). Three homebrew digital ELISA...