A5050342158- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- IL-33, ST2, and ILC Pathways
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Kawasaki Disease and Coronary Complications
- interferon and immune responses
- Asthma and respiratory diseases
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Pediatric health and respiratory diseases
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Streptococcal Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Childhood Cancer Survivors' Quality of Life
- Cell Adhesion Molecules Research
Charité - Universitätsmedizin Berlin
2016-2025
German Rheumatism Research Centre
2018-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019-2025
Humboldt-Universität zu Berlin
2004-2025
Freie Universität Berlin
2007-2025
Leibniz Association
2019-2024
American College of Rheumatology
2024
Hospital General Universitario de Alicante Doctor Balmis
2023
Hospital Universitario Nuestra Señora de Candelaria
2023
Prof. Hess Kinderklinik
2022
Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed efficacy and safety canakinumab, a selective, fully human, anti–interleukin-1β monoclonal antibody, two trials.
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report to produce evidence-based recommendations guide and other health professionals in treatment follow-up patients FMF. A multidisciplinary panel, including rheumatologists, internists, paediatricians, a nurse, methodologist patient representative, was assembled. Panellists came from Eastern area, Europe North...
The objective of this work was to develop and validate a set clinical criteria for the classification patients affected by periodic fevers. Patients with inherited fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor receptor-associated syndrome (TRAPS); cryopyrin-associated syndromes (CAPS)) enrolled in Eurofever Registry up until March 2013 were evaluated. fever, aphthosis, pharyngitis adenitis (PFAPA) used as negative controls. For each...
The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into blood study dynamics adaptive response in patients requiring intensive care. Before seroconversion SARS-CoV-2 spike protein, peripheral display a type 1 interferon-induced gene expression signature; however, following seroconversion, lose this signature, express instead signatures induced by IL-21 and TGF-β, produce mostly IgG1 IgA1....
UNC93B1 is critical for trafficking and function of nucleic acid-sensing Toll-like receptors (TLRs) TLR3, TLR7, TLR8, TLR9, which are essential antiviral immunity. Overactive TLR7 signaling induced by recognition self-nucleic acids has been implicated in systemic lupus erythematosus (SLE). Here, we report variants (E92G R336L) four patients with early-onset SLE. Patient cells or mouse macrophages carrying the produced high amounts TNF-α IL-6 upon stimulation TLR7/TLR8 agonist, but not TLR3...
The studies performed to date analyzed the overall participation of inducible costimulator (ICOS) in model diseases, but did not yield information on nature and function ICOS-expressing T cells vivo. We examined ICOS+ secondary lymphoid organs nonmanipulated mice, context an “unbiased” immune system shaped by environmental antigens. Using single cell analysis, ICOSlow were found be loosely associated with early cytokines interleukin (IL)-2, IL-3, IL-6, interferon (IFN)-γ. ICOSmedium cells,...
Fever of unknown origin (FUO) in children presents a diagnostic challenge. The differential diagnosis includes systemic-onset juvenile idiopathic arthritis (JIA), an autoinflammatory syndrome associated with activation phagocytic cells that, at presentation, is difficult to differentiate from severe systemic infections. aim this study was investigate whether serum concentrations the proinflammatory protein S100A12 may help deciding treat patients FUO antibiotics or immunosuppressive...
Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease associated with chronic arthritis. Early diagnosis and effective therapy of SJIA desirable, so that complications are avoided. The PRO-KIND initiative the German Society for Pediatric Rheumatology (GKJR) aims to define consensus-based strategies harmonize diagnostic therapeutic approaches in Germany.We analyzed data on patients diagnosed from 3 national registries Germany. Subsequently, via online surveys...
Autoantibodies against IFN-α and IFN-ω (type I IFNs) were recently reported as causative for severe COVID-19 in the general population. are present almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) caused by biallelic deleterious or heterozygous dominant mutations AIRE. We therefore hypothesized that autoantibodies IFNs also predispose APS-1 to COVID-19. prospectively studied 6 between April 1, 2020 2021. Biobanked pre-COVID-19 sera of subjects tested neutralizing...
Multisystem inflammatory syndrome in children (MIS-C) is a rare, but severe complication of coronavirus disease 2019 (COVID-19). It develops approximately 4 weeks after acute respiratory 2 (SARS-CoV-2) infection and involves hyperinflammation with multisystem injury, commonly progressing to shock. The exact pathomechanism MIS-C not known, immunological dysregulation leading cytokine storm plays central role. In response the emergence MIS-C, European Academy Allergy Clinical Immunology...
Objective Interim analysis of the RELIANCE registry, an on-going, non-interventional, open-label, multicentre, prospective study evaluating long-term safety, dosing regimens and effectiveness canakinumab in patients with cryopyrin-associated periodic syndromes (CAPS), familial Mediterranean fever (FMF), tumour-necrosis factor receptor-associated syndrome (TRAPS) or mevalonate-kinase deficiency (MKD)/hyperimmunoglobulin-D (HIDS). Methods From September 2017 for CAPS, June 2018 FMF, TRAPS...
In a subset of children and adolescents, SARS-CoV-2 infection induces severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in (MIS-C) at four to eight weeks after infection. MIS-C is characterized by specific T cell expansion2 systemic hyperinflammation3. The pathogenesis remains largely unknown. Here we show that impaired reactivation virus-reactive memory cells, which depends on increased serum levels the cytokine TGFβ resembling those occur during COVID-19 (refs....
<h3>Objective</h3> Familial Mediterranean fever (FMF) is characterised by recurrent periodic febrile attacks and persistent subclinical inflammation. The damage-associated molecular pattern (DAMP) protein S100A12 has proven to be a sensitive marker for disease activity inflammation in numerous inflammatory disorders. aim of this study was analyse the role detection patients with FMF. <h3>Methods</h3> 52 children adolescents clinical and/or genetic diagnosis FMF were prospectively followed-up...
Objectives Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential quantify individual patients and compare disease outcomes clinical studies. Currently, there no such tool. Our objective was develop a common autoinflammatory index (ADDI) for familial Mediterranean fever, cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated fever syndrome mevalonate kinase deficiency. Methods We...
Non-pharmaceutical interventions (NPI) during the COVID-19 pandemic aimed at prevention of SARS-CoV-2 transmission also influenced viruses other than SARS-CoV-2. The aim this study was to describe and compare burden common viral respiratory gastrointestinal infections in children admitted Berlin University Children's Hospital (BCH) before different levels public NPI measures.In retrospective study, we analyzed frequency detection human from January 2016 through 2022 all patients BCH. We...