A5048730761- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Neonatal and fetal brain pathology
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Gestational Trophoblastic Disease Studies
- Gestational Diabetes Research and Management
- Cerebrospinal fluid and hydrocephalus
- Pneumonia and Respiratory Infections
- Maternal and fetal healthcare
- Congenital Diaphragmatic Hernia Studies
- Ectopic Pregnancy Diagnosis and Management
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Teratomas and Epidermoid Cysts
- Congenital Anomalies and Fetal Surgery
- Tumors and Oncological Cases
- Spinal Dysraphism and Malformations
- Neuroendocrine regulation and behavior
- Genomic variations and chromosomal abnormalities
Leibniz Association
2021-2025
Hôpital Nord
2025
Hôpital Femme Mère Enfant
2014-2024
Hospices Civils de Lyon
2013-2024
Inserm
2022-2024
Centre de Recherche en Neurosciences de Lyon
2022-2024
German Rheumatism Research Centre
2021-2024
Centre National de la Recherche Scientifique
2022-2024
Université Claude Bernard Lyon 1
2011-2023
Hôpital Lyon Sud
2023
UNC93B1 is critical for trafficking and function of nucleic acid-sensing Toll-like receptors (TLRs) TLR3, TLR7, TLR8, TLR9, which are essential antiviral immunity. Overactive TLR7 signaling induced by recognition self-nucleic acids has been implicated in systemic lupus erythematosus (SLE). Here, we report variants (E92G R336L) four patients with early-onset SLE. Patient cells or mouse macrophages carrying the produced high amounts TNF-α IL-6 upon stimulation TLR7/TLR8 agonist, but not TLR3...
The Rhône-Loire metropolitan areas’ 2020/21 respiratory syncytial virus (RSV) epidemic was delayed following the implementation of non-pharmaceutical interventions (NPI), compared with previous seasons. Very severe lower tract infection incidence among infants ≤ 3 months decreased twofold, proportion cases children aged > to 5 years increased, and adults 65 were markedly reduced. NPI appeared reduce RSV burden at-risk groups, should be promoted minimise impact future outbreaks.
In a subset of children and adolescents, SARS-CoV-2 infection induces severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in (MIS-C) at four to eight weeks after infection. MIS-C is characterized by specific T cell expansion2 systemic hyperinflammation3. The pathogenesis remains largely unknown. Here we show that impaired reactivation virus-reactive memory cells, which depends on increased serum levels the cytokine TGFβ resembling those occur during COVID-19 (refs....
To define imaging patterns of unilateral cerebellar hypoplasia (UCH), discuss possible pathophysiological mechanisms and underline the etiology prognosis associated with these lesions.In this retrospective study we reviewed charts 26 fetuses diagnosed between 2003 2011 UCH, defined by asymmetrical hemispheres or without decreased transverse diameter. The review included analysis anatomy hemispheres, including foliation, borders parenchymal echogenicity, severity hypoplasia. Data from...
We report a specific sonographic cerebral pattern of cobblestone lissencephaly (CL) that has not been described previously. This was encountered in four index cases and allowed prenatal diagnosis CL associated with Walker-Warburg syndrome. The included both an outer echogenic band reduced pericerebral space, corresponding to infra- supratentorial extracortical layer neuroglial overmigration on pathological examination, 'Z'-shaped appearance the brainstem. found as early 14 weeks' gestation...
By review of a series cases, we set out to identify sonographic features suggestive an obstructive mechanism in second-trimester fetuses with ventriculomegaly and describe developmental disorders related pathological differentiation the diencephalon, mesencephalon rhombencephalon that lead obstruction cerebrospinal fluid flow. We studied retrospectively 11 referred for severe undetermined origin. Neurosonography was performed detailed analysis third ventricle, thalami, cerebral aqueduct...
In 2010 and 2011, the city of Lyon, located in Rhône-Alpes region (France), has experienced one highest incidences measles Europe. We describe a outbreak Lyon area, where cases were diagnosed at University hospitals (LUH) between mid-2011. Data collected from mandatory notification system regional public health agency, virology department LUH. All patients healthcare workers who had contracted included. Overall, 407 diagnosed, with children less than year age accounting for proportion...
We report the first series of cases pericallosal curvilinear lipoma (CL) diagnosed prenatally and highlight limitations in identifying a specific prenatal imaging pattern using ultrasound magnetic resonance (MRI). In all five our cases, on ultrasound, main feature leading to referral was short corpus callosum. This subtle callosal dysgenesis associated with band hyperechogenicity surrounding callosum, mimicking sulcus, which increased size during third trimester three four sonographic...
Our objective was to evaluate the outcome of fetuses with first- and second-trimester fetal cytomegalovirus infection (CMVi) according prenatal imaging patterns, especially presenting mild features (MF), being currently uncertain prognosis.In a retrospective study 415 suspected CMVi cases, 59 cases were confirmed. Among features, microcephaly, cortical disorder, cerebellar hypoplasia as well severe IUGR hydrops considered (SF). Other MF. Postnatal classified "normal outcome," "mild sequelae"...
Abstract Objectives Accurate assessment of gestational age (GA) is important at both individual and population levels. The most accurate way to estimate GA in women who book late pregnancy unknown. aim this study was externally validate the accuracy equations for estimation identify best equation estimating do not receive an ultrasound scan until second or third trimester. Design This a prospective, observational cross‐sectional study. Setting 57 prenatal care centres, France. Participants...
<b><i>Objectives:</i></b> The aim of this study was to report the prenatal imaging findings expanding porencephalic cyst, which have not been previously described in period, and underline that these lesions can involve cerebellum exclusively supratentorial structures. <b><i>Materials Methods:</i></b> This is a retrospective observational five cases with diagnosis cyst. <b><i>Results:</i></b> cystic lesion located supra-...
The impact of using the Intergrowth (IG) dating formulae in comparison to commonly used Robinson on evaluation biometrics and estimated fetal weight (EFW) has not been evaluated.Nationwide cross-sectional study routine ultrasound biometry low-risk pregnant women whose gestational age (GA) had previously assessed by a first trimester CRL measurement. We compared CRL-based GA according formula IG formula. evaluated biometric measurements as well EFW taken later pregnancy depending used. Mean...
<b><i>Objectives:</i></b> Our goal was to provide a better understanding of isolated short corpus callosum (SCC) regarding prenatal diagnosis and postnatal outcome. <b><i>Methods:</i></b> We retrospectively reviewed imaging, clinical, biological data from 42 cases with SCC. <b><i>Results:</i></b> Prenatal imaging showed SCC in all (<i>n</i> = 42). limited rostrum and/or genu splenium 21 cases, involved body...