A5028592793- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Spinal Dysraphism and Malformations
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Congenital Anomalies and Fetal Surgery
- Teratomas and Epidermoid Cysts
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Genetic and Kidney Cyst Diseases
- Cleft Lip and Palate Research
- Tumors and Oncological Cases
- Pediatric Hepatobiliary Diseases and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Parvovirus B19 Infection Studies
- Genomic variations and chromosomal abnormalities
- Intestinal Malrotation and Obstruction Disorders
- Tracheal and airway disorders
- Connective tissue disorders research
- Head and Neck Anomalies
- Craniofacial Disorders and Treatments
- Congenital gastrointestinal and neural anomalies
- Assisted Reproductive Technology and Twin Pregnancy
Sorbonne Université
2016-2025
Hôpital Armand-Trousseau
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Inserm
1998-2024
Tel Aviv Sourasky Medical Center
2024
Hôpital d'Enfants
2013-2023
Laboratoire National de Référence
2022-2023
Hudson Institute
2019
John Wiley & Sons (United Kingdom)
2019
Hôpitaux Universitaires Paris-Ouest
2012-2019
We detected an unusual increase in congenital cerebral malformations and dysfunction fetuses newborns French Polynesia, following epidemic of Zika virus (ZIKV), from October 2013 to March 2014. A retrospective review identified 19 cases, including eight with major brain lesions severe microcephaly, six without microcephaly five brainstem visible malformations. Imaging revealed profound neurological (septal callosal disruption, ventriculomegaly, abnormal neuronal migration, cerebellar...
Abstract Background: Fetuses from mothers with Graves’ disease may experience hypothyroidism or hyperthyroidism due to transplacental transfer of antithyroid drugs (ATD) anti-TSH receptor antibodies, respectively. Little is known about the fetal consequences. Early diagnosis essential successful management. We investigated a new approach thyroid dysfunction and validated usefulness ultrasonograms. Methods: Seventy-two past present their fetuses were monitored monthly 22 wk gestation. Fetal...
Abstract Objectives To investigate the correlation between fetal lung volume (FLV), measured with magnetic resonance imaging (MRI), and postnatal mortality in newborns prenatally diagnosed isolated congenital diaphragmatic hernia (CDH). Methods In a 4‐year prospective multicenter study, 77 fetuses CDH 20 33 weeks' gestation underwent fast spin‐echo T2‐weighted MRI. These MRI‐FLV measurements were compared previously published normative curve obtained 215 without thoracoabdominal...
To provide normal magnetic resonance imaging (MRI) reference biometric data of the fetal brain, to evaluate reproducibility and gender effect, compare two cerebral hemispheres MRI with ultrasonographic biometry, in a large cohort.Normal examinations were collected prospectively several parameters measured: supratentorial space (bone fronto-occipital biparietal (BPD) diameters), length corpus callosum (LCC), surface area, height anteroposterior diameter vermis, transverse cerebellar (TCD)...
To define the contribution of prenatal investigation and evaluate prognosis isolated mild ventriculomegaly (IMV).Retrospective study.University hospital between January 1992 December 2002.One hundred sixty-seven cases unilateral or bilateral IMV without any associated anomaly at time initial diagnosis.Complementary investigations were performed: amniocentesis with karyotyping, screening for viruses acetylcholinesterase electrophoresis, magnetic resonance imaging (MRI), ultrasonography every...
Magnetic resonance imaging (MRI) has revealed isolated pituitary stalk (PS) thickening (PST) in certain cases of idiopathic or secondary central diabetes insipidus (DI) due to infiltrative processes. Twenty-six children with DI and PST underwent cerebral MRI at the age 8 +/- 4 yr were followed (n = 24) by clinical evaluation, respectively, for 5.5 3.6 3.0 2 absence any treatment other than hormonal substitutive therapy. Patients subdivided into groups according etiology DI: germinoma 4),...
Congenital hypothyroidism (CH) is most frequently caused by thyroid developmental abnormalities and it has recently been seen to have a familial component. The aim of this study was investigate whether exist in first degree relatives CH children with dysgenesis, an anomaly which, when present, sometimes asymptomatic. Thyroid ultrasonography function were evaluated among (n = 241) 84 isolated dysgenesis. results compared those unselected control population 217). In 19 individuals (7.9% cases)...
Summary Objective To determine the proportion of various types thyroid disorders among newborns detected by neonatal TSH screening programme, with a normally located gland. Patients and methods Of 882 575 infants screened in our centre between 1981 2002, 85 gland had persistent elevation serum values (an incidence 1/10 383). Six these patients were lost to follow‐up therefore excluded from study. During follow‐up, classified as having permanent or transient hypothyroidism. Results Among 79...
<h3>BACKGROUND AND PURPOSE:</h3> The availability of data relating to the biometry CC in children that are easy use daily practice is limited. We present a reference MR imaging large cohort children. <h3>MATERIALS METHODS:</h3> Cerebral studies with normal examination findings were selected retrospectively. Children born preterm and those or at risk developing cerebral malformations excluded. following parameters measured: FOD, APD, LCC, GT, BT, IT, ST, S/T. Inter- intraobserver agreement...
Pontocerebellar hypoplasia (PCH) is a heterogeneous group of diseases characterized by lack development and/or early neurodegeneration cerebellum and brainstem. According to clinical features, seven subtypes PCH have been described, type 2 related TSEN54 mutations being the most frequent. often autosomal recessive though de novo anomalies in X-linked gene CASK recently identified patients, mostly females, presenting with intellectual disability, microcephaly (MICPCH). Fourteen patients (12...
Isolated central diabetes insipidus (CDI) can be the first manifestation of Langerhans cell histiocytosis (LCH), creating diagnostic dilemmas such as dysgerminoma and other inflammatory lesions.In 2010, French national LCH registry had enrolled 1236 patients under 18 yr age. CDI was initial presentation in 26 patients. We reviewed their clinical magnetic resonance imaging (MRI) features.Median age at diagnosis 9.6 (1.8-16.3), median follow-up after 9.9 (3.5-26.6). In addition to CDI, two...
Subtelomeric 1q43q44 microdeletions cause a syndrome associating intellectual disability, microcephaly, seizures and anomalies of the corpus callosum. Despite several previous studies assessing genotype-phenotype correlations, contribution genes located in this region to specific features remains uncertain. Among those, three genes, AKT3, HNRNPU ZBTB18 are highly expressed brain point mutations these have been recently identified children with neurodevelopmental phenotypes. In study, we...