A5084611399- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Adolescent and Pediatric Healthcare
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Neurogenetic and Muscular Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Systemic Sclerosis and Related Diseases
- Renal Diseases and Glomerulopathies
- Kawasaki Disease and Coronary Complications
- Musculoskeletal Disorders and Rehabilitation
- Osteomyelitis and Bone Disorders Research
- Acute Lymphoblastic Leukemia research
- Celiac Disease Research and Management
- Orthopedic Infections and Treatments
- Heterotopic Ossification and Related Conditions
- Childhood Cancer Survivors' Quality of Life
- Muscle and Compartmental Disorders
- Child and Adolescent Health
- Infectious Diseases and Tuberculosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Liverpool
2015-2025
Harlem Hospital Center
2023-2025
Alder Hey Children's NHS Foundation Trust
2016-2025
Columbia University Irving Medical Center
2025
Columbia University
2025
Children’s Foundation
2012-2025
University of Illinois Chicago
2025
Medizinische Hochschule Brandenburg Theodor Fontane
2024
Alder Hey Children's Hospital
2014-2024
University College London
2006-2022
Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed efficacy and safety canakinumab, a selective, fully human, anti–interleukin-1β monoclonal antibody, two trials.
IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning appropriate diagnosis and treatment IgAV children. Accordingly, regimens differ widely. The European initiative SHARE (Single Hub Access point for paediatric Rheumatology Europe) aims to optimize care children with rheumatic diseases. aim therefore was provide agreed consensus recommendations...
Aims The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled data. Methods Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. Results Of 3067 cases, 69% female. most common subtype dermatomyositis (DM) (31%). Smoking more frequent in connective...
Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem and potentially life-threatening autoimmune disorder with significant associated morbidity. Evidence-based guidelines are sparse management often based on clinical expertise. SHARE (Single Hub Access point for paediatric Rheumatology in Europe) was launched to optimise disseminate regimens children young adults rheumatic diseases like cSLE. Here, we provide evidence-based recommendations diagnosis treatment of In view...
BackgroundIdiopathic inflammatory myopathy (IIM) is a multi-system autoimmune condition characterised by muscle inflammation (myositis), interstitial lung disease (ILD), and skin manifestations with an incidence of up to 19 per 1,000,000 person-years in adults 4 children.Estimated UK prevalence (for adult-onset IIM) 10, 000 [1,2]. Need for guidelineNo rigorously produced evidence-based guidelines IIM spanning juvenile exists.Assimilating key research relating management formation practical...
To identify epidemiological, clinical and laboratory characteristics of juvenile dermatomyositis (JDM) in a national multi-centre cohort patients, to review recent changes the understanding management prognosis light these data.All children with idiopathic inflammatory myositis recruited Juvenile Dermatomyositis National Registry Repository (UK Ireland) were included. Features at presentation, later disease, assessed evaluated. A total 63 out 175 new diagnosis time followed prospectively....
We investigated eight families with a novel subtype of congenital generalized lipodystrophy (CGL4) whom five members had died from sudden cardiac death during their teenage years. ECG studies revealed features long-QT syndrome, bradycardia, as well supraventricular and ventricular tachycardias. Further symptoms comprised myopathy muscle rippling, skeletal smooth-muscle hypertrophy, leading to impaired gastrointestinal motility hypertrophic pyloric stenosis in some children. Additionally, we...
The UK Juvenile-Onset Systemic Lupus Erythematosus (JSLE) Cohort Study is a multicenter collaborative network established with the aim of improving understanding juvenile SLE. present study was undertaken to describe clinical manifestations and disease course in patients SLE from this large, national inception cohort.Detailed data on phenotype were collected at baseline regular clinic reviews annual followup assessments 232 14 centers across over 4.5 years. Patients identified according...
Some juvenile dermatomyositis (JDM) patients have a disease course which is refractory to multiple drug treatments. Prolonged activity associated with increased mortality and morbidity. TNF-alpha has been identified in high levels JDM who long calcinosis. We assessed the response of five anti-TNF-alpha monoclonal antibody, infliximab.For all intravenous infliximab was initially given at dose 3 mg/kg. Further doses were then weeks 2, 6 every 8 thereafter. The frequency tailored accordance...
Abstract Objectives The European Single Hub and Access point for paediatric Rheumatology in Europe initiative aimed to optimize care children with rheumatic diseases. Kawasaki disease (KD) is the most common cause of acquired heart an important long-term cardiac into adulthood. Prompt diagnosis treatment KD difficult due heterogeneity but crucial improving outcome. To date, there are no internationally agreed, evidence-based guidelines concerning children. Accordingly, regimens differ...
Lupus nephritis (LN) occurs in 50%–60% of patients with childhood-onset systemic lupus erythematosus (cSLE), leading to significant morbidity. Timely recognition renal involvement and appropriate treatment are essential prevent damage. The Single Hub Access point for paediatric Rheumatology Europe (SHARE) initiative aimed generate diagnostic management regimens children adolescents rheumatic diseases including cSLE. Here, we provide evidence-based recommendations diagnosis childhood LN....
Abstract Objectives The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care children with rheumatic diseases. Systemic vasculitides are very rare children. Consequently, despite recent advances, paediatric-specific information is sparse. lack of evidence-based recommendations an important, unmet need. This study provide diagnosing treating forms childhood systemic vasculitis. Methods Recommendations were developed by a...
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the pathogen responsible for Disease 2019 (COVID-19). Whilst most children and young people develop mild symptoms, recent reports suggest a paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Case definition classification are preliminary, treatment empiric disease-associated outcomes unclear. Here, we report 29 patients PIMS-TS who were diagnosed, admitted treated in English...
Objectives. Adult studies have demonstrated that ultrasonography (US) is more sensitive at detecting synovitis than clinical examination. The detection of subclinical disease has implications for deciding which patients receive aggressive therapy from the outset. This study aimed to determine whether children with clinically diagnosed oligoarticular juvenile idiopathic arthritis (JIA) had US-detectable synovitis. Methods. was a cross-sectional pilot conducted in tertiary paediatric...
Objectives. To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those JDM–scleroderma (JDM–SSc) overlap, using detailed serological analysis, HLA class II genotyping clinical characterization. Methods. Children (114) JDM were recruited, data collected, through the National Registry Repository (UK Ireland). Sera assayed for ANA standard immunofluorescence techniques specific antibodies characterized ELISA, immunodiffusion radioimmunoprecipitation. Patients...
Chronic nonbacterial osteomyelitis (CNO) can cause significant morbidity, including bone pain and damage. In the absence of clinical trials, treatments include non-steroidal anti-inflammatory drugs, corticosteroids, TNF-inhibitors (TNFi) and/or bisphosphonates. a retrospective chart review in United Kingdom Germany, we investigated response to TNFi pamidronate. Ninety-one patients were included, receiving pamidronate (n = 47), 22) or both sequentially 22). Patients with fatigue [p 0.003]...
Groups of 25 children with cerebral palsy (CP), inflammatory bowel disease (IBD), and cancer were compared to healthy establish use complementary or alternative medicine (CAM). Children chronic greater than three times more likely CAM, usually without paediatricians' knowledge.
Objective. Joint hypermobility, common in childhood, can be associated with severe pain and significant morbidity. Physiotherapy, the mainstay of treatment, lacks a robust evidence base. This study is aimed at determining best physiotherapy intervention managing childhood hypermobility.