A5015582099- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Mast cells and histamine
- IL-33, ST2, and ILC Pathways
- Food Allergy and Anaphylaxis Research
- Exercise and Physiological Responses
- Sinusitis and nasal conditions
- Respiratory and Cough-Related Research
- Autoimmune Bullous Skin Diseases
- Pediatric health and respiratory diseases
- Thermoregulation and physiological responses
- Advancements in Transdermal Drug Delivery
- Contact Dermatitis and Allergies
- Skin Diseases and Diabetes
- Inflammasome and immune disorders
- Olfactory and Sensory Function Studies
- Eosinophilic Esophagitis
- Inflammatory Myopathies and Dermatomyositis
- Nasal Surgery and Airway Studies
- Immune Cell Function and Interaction
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders
- COVID-19 Clinical Research Studies
Vrije Universiteit Brussel
2018-2024
Universitair Ziekenhuis Brussel
2018-2024
Charité - Universitätsmedizin Berlin
2023
Institute for Gerontological Research
2021
KU Leuven
2016-2019
Aarhus University Hospital
2013-2016
Aarhus University
2013-2015
BackgroundTight junction (TJ) defects have recently been associated with asthma and chronic rhinosinusitis. The expression, function, regulation of nasal epithelial TJs remain unknown in patients allergic rhinitis (AR).ObjectiveWe investigated the epithelium house dust mite (HDM)–induced AR an HDM-induced murine model airway disease.MethodsAir-liquid interface cultures primary cells control subjects were used for measuring transepithelial resistance passage to fluorescein...
BackgroundAllergic rhinitis (AR) is characterized by mucosal inflammation, driven activated immune cells. Mast cells and TH2 might decrease epithelial barrier integrity in AR, maintaining a leaky barrier.ObjectiveWe sought to investigate the role of histamine driving dysfunction AR.MethodsAir-liquid interface cultures primary nasal were used measure transepithelial electrical resistance, paracellular flux fluorescein isothiocyanate-dextran 4 kDa, mRNA expression tight junctions. Nasal...
Multisystem inflammatory syndrome in children (MIS-C) is a rare, but severe complication of coronavirus disease 2019 (COVID-19). It develops approximately 4 weeks after acute respiratory 2 (SARS-CoV-2) infection and involves hyperinflammation with multisystem injury, commonly progressing to shock. The exact pathomechanism MIS-C not known, immunological dysregulation leading cytokine storm plays central role. In response the emergence MIS-C, European Academy Allergy Clinical Immunology...
Abstract Background Increased epithelial permeability has been reported in allergic rhinitis, with histamine and type‐2 inflammation being responsible for tight junction dysfunction. The impact of an barrier defect on sensitization mast cell (MC) degranulation remains speculative. Methods Transepithelial passage allergens was evaluated primary human nasal cultures. Active attempted by repeated intranasal ovalbumin (OVA) applications Naïve mice. In a passive model, mice were injected IgE to...
Abstract Background Autoreactive immunoglobulin E (IgE) antibodies to self‐peptides within the epidermis have been identified in patients with atopic dermatitis (AD). Prevalence, concomitant diseases, patient characteristics, and risk factors of IgE autoantibody development remain elusive. We aimed determine autoantibodies serum samples ( n = 672) from well‐characterized AD controls (1.2–88.9 years). Methods Atopic were sub‐grouped comorbid Type‐2 diseases (“AD + Type 2”; asthma, allergic...
Abstract Background Janus kinase (JAK) inhibition may be a promising new treatment modality for inflammatory (skin) diseases. However, little is known about direct effects of inhibitors on keratinocyte differentiation and function as well skin barrier formation. Objective Our aim was to address the impact JAK1/3 pathways by tofacitinib immune formation in atopic dermatitis (AD) psoriasis. Methods 3D equivalents both diseases were developed concurrently pretreated with tofacitinib. To induce...
Abstract Background Nasal hyperreactivity ( NHR ) is an important clinical feature of allergic rhinitis AR ). The efficacy MP 29‐02 (azelastine hydrochloride AZE and fluticasone propionate [ FP ]) nasal spray on local inflammatory mediators in unknown. We tested if decreases this effect due to restoration epithelial barrier function. Methods A 4‐week double‐blinded placebo‐controlled trial with treatment was conducted 28 patients house dust mite HDM . presence evaluated by measuring...
Summary Background The toll‐like receptors, TLR5 and TLR7, have recently been proposed in asthma immunopathogenesis. While supporting data come from animal or vitro studies, little is known about TLR7 expression human asthmatic airways. Methods Advanced immunohistochemical mapping of was performed on bronchial transbronchial biopsies healthy individuals patients with moderate severe asthma. Results identified multiple structural cells; epithelium, alveolar type II pneumocytes, plasma cells,...
The first European Rhinology Research Forum organized by the for and Education in Allergy Airway Diseases (EUFOREA) was held Royal Academy of Medicine Brussels on 17th 18th November 2016, collaboration with Rhinologic Society (ERS) Global Asthma Network (GA2LEN). One hundred thirty participants (medical doctors from different specialties, researchers, as well patients industry representatives) 27 countries took part multiple perspective discussions including brainstorming sessions care...
Skin barrier function assessment is commonly done by measuring transepidermal water loss (TEWL). An important limitation of this method the influence intrinsic and extrinsic factors. Electrical impedance spectroscopy (EIS) a lesser-established for skin assessment. Some influential factors have been described, but no guidelines exist regarding standardization these measurements.
Abstract Background Programmed cell death‐1 (PD‐1) is a negative regulator of T‐cell responses. Expression PD‐1 and its ligands PD‐L1 PD‐L2 in chronic rhinosinusitis with nasal polyps (CRSwNP) poorly studied. Methods PD‐1, PD‐L1, PD‐L2, TGF‐β, IL‐5, IL‐10 mRNA was measured by real‐time quantitative PCR on tissue homogenates patients CRSwNP ( n = 21) healthy controls primary epithelial cells. Disease severity scored using the Lund–Mackay scores maxillofacial computed tomography (CT) scans....