A5042940137- Gastrointestinal motility and disorders
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Dermatology and Skin Diseases
- Diet and metabolism studies
- Congenital gastrointestinal and neural anomalies
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Infant Health and Development
- Mast cells and histamine
- Ion Transport and Channel Regulation
- Digestive system and related health
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Music Therapy and Health
- Immune Cell Function and Interaction
- Caveolin-1 and cellular processes
- Microtubule and mitosis dynamics
- Pain Mechanisms and Treatments
- Amino Acid Enzymes and Metabolism
- Olfactory and Sensory Function Studies
- Whipple's Disease and Interleukins
- Therapeutic Uses of Natural Elements
KU Leuven
2013-2025
Catholic University of America
2010
University of Rochester
2009
Mayo Clinic
2007
Mayo Clinic in Arizona
2007
Université Libre de Bruxelles
2005-2006
Janssen (Belgium)
2005-2006
Center for Digestive and Liver Diseases
2006
Johnson & Johnson (Sweden)
2005
<h3>Background</h3> Mast cell activation is thought to be involved in visceral hypersensitivity, one of the main characteristics irritable bowel syndrome (IBS). A study was therefore undertaken investigate effect mast stabiliser ketotifen on rectal sensitivity and symptoms patients with IBS. <h3>Methods</h3> 60 IBS underwent a barostat assess before after 8 weeks treatment. After initial barostat, were randomised receive or placebo. health-related quality life scored. In addition, cells...
<h3>Objective</h3> IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true risk factors by means of genome-wide association (GWA) and independent replication studies. <h3>Design</h3> conducted a GWA study (GWAS) in general population sample 11 326 Swedish twins. cases (N=534) asymptomatic controls (N=4932) were identified based on questionnaire data. Suggestive signals followed-up 3511 individuals from six case-control...
Abstract Irritable bowel syndrome is in part characterized by an increased sensitivity to colonic distension. Stress important trigger factor for symptom generation. We hypothesized that stress induces visceral hypersensitivity via mast cell degranulation and transient receptor ion channel 1 (TRPV1) modulation. used the rat model of neonatal maternal separation (MS) investigate this hypothesis. The visceromotor response distention was assessed adult MS non‐handled (NH) rats before after...
Abnormal pain perception or visceral hypersensitivity (VH) is considered to be an important mechanism underlying symptoms in a subgroup of irritable bowel syndrome (IBS) patients. Increased TRPV1 (transient receptor potential cation channel subfamily V member 1) expression rectal biopsies IBS patients suggests potentially role for this nociceptor the pathophysiology IBS. However, evidence underscoring involvement lacking. The objective study was evaluate VH distension and clinical with IBS.A...
OBJECTIVES: Repeated exposure to stress leads mast cell degranulation, microscopic inflammation, and subsequent visceral hypersensitivity in animal models. To what extent this pathophysiological pathway has a role patients with the irritable bowel syndrome (IBS) not been properly investigated. The objective of study was assess relationship between hypersensitivity, response IBS. METHODS: Microscopic inflammation colonic mucosa evaluated by immunohistochemistry 66 IBS 20 healthy volunteers...
<h3>Objective</h3> Psychological factors increase the risk to develop postinfectious IBS (PI-IBS), but mechanisms involved are unclear. As stress affects immune system, we investigated potential interaction between psychological factors, response against infectious gastroenteritis (IGE) and development of IGE PI-IBS in a large cohort exposed contaminated drinking water. <h3>Design</h3> 18 620 people water (norovirus, <i>Giardia lamblia</i>, <i>Campylobacter jejuni</i>) were invited...
Patients with irritable bowel syndrome (IBS) often associate their symptoms to certain foods. In congenital sucrase-isomaltase deficiency (CSID), recessive mutations in the SI gene (coding for disaccharidase digesting sucrose and 60% of dietary starch)1 cause clinical features IBS through colonic accumulation undigested carbohydrates, triggering symptoms.2 Hence, a previous study,3 we hypothesized that CSID variants reducing enzymatic activity may contribute development symptoms. We detected...
Objective Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation. To what extent these molecules could also have a beneficial effect on TRPV1 sensitisation visceral hypersensitivity (VHS), mechanisms involved IBS, remains unknown. Design The of RvD1, RvE1 activation histamine or IBS supernatants was assessed murine dorsal root ganglion...
The factors underlying the survival and maintenance of interstitial cells Cajal (ICC) are not well understood. Loss ICC is often associated with loss neuronal nitric oxide synthase (nNOS) in humans, suggesting a possible link. aim this study was to determine effect NO on mouse gastric body. volumes were determined nNOS(-/-) control mice body organotypic cultures using immunohistochemistry, laser scanning confocal microscopy three-dimensional reconstruction. numbers primary cell after...
Aliment Pharmacol Ther 2011; 34: 638–648 Summary Background Functional dyspepsia is one of the most prevalent (15–40%) functional gastrointestinal disorders. Antidepressants such as amitriptyline are often used in these patients, but clinical studies currently lacking. Aim To evaluate effect 8 weeks treatment with on drinking capacity, symptoms evoked by a standardised drink test (primary endpoint) and (secondary endpoint). Methods Patients meeting Rome III criteria for (FD) were invited to...
Post-infectious irritable bowel syndrome (PI-IBS) is a common gastrointestinal disorder characterized by persistent abdominal pain despite recovery from acute gastroenteritis. The underlying mechanisms are unclear, although long-term changes in neuronal function, and low grade inflammation of the have been hypothesized. We investigated presence mechanism sensitization unique cohort individuals who developed PI-IBS following exposure to contaminated drinking water 7 years ago. provide direct...
Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates IBS pathophysiology since they regulate gut motor function stool consistency, targeted 5-HT4R selective drug intervention has been proven beneficial subgroups of patients. We identified single nucleotide polymorphism (SNP) (rs201253747) c.*61 T > C within the receptor gene HTR4 to be predominantly present diarrhoea-IBS...
Abstract Background Nasal hyperreactivity ( NHR ) is an important clinical feature of allergic rhinitis AR ). The efficacy MP 29‐02 (azelastine hydrochloride AZE and fluticasone propionate [ FP ]) nasal spray on local inflammatory mediators in unknown. We tested if decreases this effect due to restoration epithelial barrier function. Methods A 4‐week double‐blinded placebo‐controlled trial with treatment was conducted 28 patients house dust mite HDM . presence evaluated by measuring...
Previously, we showed histamine-mediated sensitization of transient receptor potential (TRP) vanilloid 1 (TRPV1) in patients with irritable bowel syndrome (IBS). Sensitization TRP ankyrin (TRPA1) and 4 (TRPV4) are also involved aberrant pain perception preclinical models somatic pain. Here, hypothesize that parallel TRPV1, histamine sensitizes TRPA1 TRPV4, contributing to increased visceral IBS. Rectal biopsies were collected from IBS healthy subjects (HS) study neuronal sensitivity TRPV4...