A5084226167- Gastrointestinal motility and disorders
- Immune cells in cancer
- Gut microbiota and health
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Congenital gastrointestinal and neural anomalies
- Immune responses and vaccinations
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Microplastics and Plastic Pollution
- Vagus Nerve Stimulation Research
- Liver Disease and Transplantation
- Acupuncture Treatment Research Studies
- Clinical Nutrition and Gastroenterology
- Single-cell and spatial transcriptomics
- Diet and metabolism studies
- Ion Channels and Receptors
- Genomics, phytochemicals, and oxidative stress
- Nitrogen and Sulfur Effects on Brassica
- Infant Health and Development
- Enhanced Recovery After Surgery
- Trigeminal Neuralgia and Treatments
- Paleopathology and ancient diseases
- MicroRNA in disease regulation
University of Bonn
2023-2025
KU Leuven
2018-2025
National University of Tucumán
2025
University College Cork
2017-2024
APC Microbiome Institute
2017-2024
The perception of visceral pain is a complex process involving the spinal cord and higher order brain structures. Increasing evidence implicates gut microbiota as key regulator behavior, yet it remains to be determined if bacteria play role in sensitivity. We used germ-free mice (GF) assess sensitivity, gene expression pain-related GF displayed hypersensitivity accompanied by increases Toll-like receptor cytokine cord, which were normalized postnatal colonization with from conventionally...
Objectives Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive muscularis macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 (5-HT4R) agonist prucalopride can mimic this effect in mice human. Design Using Ca 2+ imaging, the electrical field (EFS) was situ on mMφ evoked ATP jejunal tissue. Next, preoperative administration (1–5...
The enteric microbiota is characterised by a balance and composition that unique to the host. It important understand mechanisms through which host can maintain of gut microbiota. MicroRNAs (miRNA) are implicated in intercellular communication have been isolated from bodily fluids including stool. Recent findings suggest miRNA produced host’s intestinal epithelial cells (IECs) participate shaping To investigate whether expression was influenced we measured miRNAs expressed faeces....
Previously, we showed histamine-mediated sensitization of transient receptor potential (TRP) vanilloid 1 (TRPV1) in patients with irritable bowel syndrome (IBS). Sensitization TRP ankyrin (TRPA1) and 4 (TRPV4) are also involved aberrant pain perception preclinical models somatic pain. Here, hypothesize that parallel TRPV1, histamine sensitizes TRPA1 TRPV4, contributing to increased visceral IBS. Rectal biopsies were collected from IBS healthy subjects (HS) study neuronal sensitivity TRPV4...
(Z)‐3‐butylamino‐4,4,4‐trifluoro‐1‐(2‐hydroxyphenyl)but‐2‐en‐1‐one (1), a new β‐aminoenone, has been investigated in terms of its intra‐ and intermolecular interactions. Vibrational, electronic NMR spectroscopies were used for the characterization, while X‐ray diffraction methods afforded determination crystal structure. The compound is arranged lattice as centre‐symmetric H‐bonded dimeric aggregates (C2/c monoclinic space group). Both experimental (IR, Raman, UV‐Vis transitions data)...
Background Mast cell activation is an important driver of abdominal pain in irritable bowel syndrome (IBS). While evidence supports the role IgE-mediated mast visceral development IBS, pseudoallergic MRGPRX2-mediated this process remains unknown. Objective We investigated whether plays a patients with IBS. Design MRGPRX2 expression cells and other immune was characterised across colon layers using flow cytometry. evaluated agonists trigger degranulation transient receptor potential vanilloid...
During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen stored in hepatocytes and later metabolized glucose, meeting demands of neonate. Shortly after lipogenesis begins, driven by transcriptional activation enzymes involved fatty acid oxidation. These processes are thought be largely systemic insulin glucagon levels. However, role liver-derived local factors neonatal hepatocyte remains unexplored. Kupffer cells...
<title>Abstract</title> Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, nano- and microplastic particles (MNPs) can translocate from gut internal organs, with macrophages serving as primary targets. Kupffer cells (KCs), liver-resident macrophages, play a central role in surveillance metabolism, their response MNPs remains unclear. Here, using chronic plastic exposure model mice, we identify KCs hepatic reservoir for MNPs. Long-term...
Abstract The gut microbiota has been shown to be an important regulator of brain and behaviour. Germ-free rodents are a key model study the microbiome-gut-brain axis reveal microbial underpinnings diseases, including those related psychiatric illnesses. present evaluated whether absence could alter morphological development nucleus accumbens, region located in ventral striatum involved stress, mood addiction. In germ-free mice, there was dendritic hypertrophy medium spiny neurons shell...
Vegetable crops of Brassica oleracea contain significant amounts antioxidant compounds, such as glucosinolates (GLS) which, upon disruption the tissue, are broken down by endogenous enzyme myrosinase (MYR), resulting in production isothiocyanates, thiocyanates, nitriles, goitrin and epithionitriles. In particular, isothiocyanates known to exert beneficial effects for human health. Several studies describe (ITCs) inhibitors mitosis stimulators apoptosis tumor cells. The Sicilian black...