A5089101291- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Dermatology and Skin Diseases
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Inflammatory Bowel Disease
- Congenital gastrointestinal and neural anomalies
- Digestive system and related health
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Infant Health and Development
- Esophageal Cancer Research and Treatment
- Barrier Structure and Function Studies
- Probiotics and Fermented Foods
- Asthma and respiratory diseases
- Stress Responses and Cortisol
- Celiac Disease Research and Management
- Dietary Effects on Health
- Immune Response and Inflammation
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Clinical Nutrition and Gastroenterology
Vall d'Hebron Hospital Universitari
2012-2025
Vall d'Hebron Institut de Recerca
2015-2025
Nestlé (Switzerland)
2021-2025
Universitat Autònoma de Barcelona
2013-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013-2024
Instituto de Salud Carlos III
2011-2024
Hospital Universitario La Paz
2023
Ministry of Economy, Industry and Competitiveness
2017-2018
Action Network
2017
Research Network (United States)
2017
<b>Background:</b> Increased numbers of mast cells and cell activation in distal gut segments are associated with symptom onset severity irritable bowel syndrome (IBS). Although upper symptoms common, have not been thoroughly evaluated proximal IBS patients. <b>Methods:</b> Jejunal biopsies obtained by Watson’s capsule, aspiration intestinal fluid one blood sample were 20 diarrhoea-predominant patients (D-IBS) 14 healthy volunteers (H). Psychological stress (Holmes-Rahe Scale) depression...
<h3>Objective</h3> Functional dyspepsia (FD) is an extremely common functional gastrointestinal disorder, the pathophysiology of which poorly understood. We hypothesised that impaired intestinal barrier function involved in onset and persistence this disorder by inducing low-grade inflammation. Therefore, our aim was to evaluate duodenal mucosal integrity inflammation patients with FD. <h3>Design</h3> Duodenal biopsy specimens were obtained from 15 FD fulfilling Rome III criteria age-...
<h3>Objective</h3> Recently, the authors demonstrated altered gene expression in jejunal mucosa of diarrhoea-predominant irritable bowel syndrome patients (IBS-D); specifically, showed that genes related to mast cells and intercellular apical junction complex (AJC) were expressed differently than healthy subjects. The aim here was determine whether these alterations are associated with structural abnormalities AJC their relationship cell activation IBS-D clinical manifestations....
<h3>Background</h3> Oesophageal intraluminal impedance is currently used for assessment of reflux in gastro-oesophageal disease (GORD). mucosa integrity may have a key role heartburn perception non-erosive (NERD). Severe erosive oesophagitis associated with low baseline. We hypothesised that baseline measurements could be to evaluate changes oesophageal man. <h3>Methods</h3> measured before, during and after acid perfusion rabbits healthy subjects. Transepithelial resistance (TER) was...
<h3>Background:</h3> Eosinophilic oesophagitis (EO) is an emerging yet increasingly prevalent disorder characterised by a dense and selective eosinophilic infiltration of the oesophageal wall. While EO considered atopic disease primarily triggered food antigens, disparities between standard allergen testing clinical responses to exclusion diets suggest participation distinct antigen-specific immunoglobulin E (IgE) in pathophysiology EO. <h3>Aim:</h3> To find evidence for local IgE response....
Diarrhea-predominant irritable bowel syndrome (IBS-D) patients show altered epithelial permeability and mucosal micro-inflammation in both proximal distal regions of the intestine. The objective this study was to determine molecular events mechanisms clinical role upper small intestinal alterations.Clinical assessment a jejunal biopsy obtained IBS-D healthy subjects. Routine histology immunohistochemistry performed all participants assess number mast cells (MCs) intraepithelial lymphocytes....
Background: The diagnosis of anaphylaxis is based on clinical history since no reliable biological marker currently available to confirm the diagnosis. Objective: It was aim this study determine sequential serum tryptase concentrations during and evaluate its potential as a diagnostic marker. Methods: We performed prospective including patients with acute (according National Institute Allergy Infectious Disease/Food Anaphylaxis Network criteria) attending emergency department. Demographic...
<h3>Objective</h3> Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) correlated with ultrastructural abnormalities patients diarrhoea-predominant IBS (IBS-D). However, participation miRNAs these mRNA-associated findings remains to be established. Our aims were (1) identify differentially expressed small bowel mucosa IBS-D...
The etiopathogenesis of the irritable bowel syndrome (IBS), one most prevalent gastrointestinal disorders, is not well known. accepted hypothesis that IBS result disturbance 'brain-gut axis.' Although pathophysiological mechanisms intestinal dysfunction are complex and completely understood, stress, infections, gut flora, altered immune response thought to play a role in development. barrier, composed single-cell layer, forms physical barrier separates lumen from internal milieu. loss...
<h3>Background and aims</h3> Altered intestinal barrier is associated with immune activation clinical symptoms in diarrhoea-predominant IBS (IBS-D). Increased mucosal antigen load may induce specific responses; however, local antibody production its contribution to aetiopathogenesis remain undefined. This study evaluated the role of humoral activity IBS-D. <h3>Methods</h3> A single jejunal biopsy, luminal content blood were obtained from healthy volunteers (H; n=30) IBS-D (n=49; Rome III...
Summary Background Intestinal immune activation is involved in irritable bowel syndrome ( IBS ) pathophysiology. While most dietary approaches involve food avoidance, there are fewer indications on supplementation. Palmithoylethanolamide, structurally related to the endocannabinoid anandamide, and polydatin compounds which act synergistically reduce mast cell activation. Aim To assess effect count efficacy of palmithoylethanolamide/polydatin patients with . Methods We conducted a pilot,...
The interface between the intestinal lumen and mucosa is location where majority of ingested immunogenic particles face scrutiny vast gastrointestinal immune system. Upon regular physiological conditions, microflora epithelial barrier are well prepared to process daily a huge amount food-derived antigens non-immunogenic particles. Similarly, they ready prevent environmental toxins microbial penetrate further interact with mucosal-associated These functions promote development proper...
Abstract We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function functional dyspepsia (FD). aimed to further describe the implication of these immune cells by assessing their activation state at ultrastructural level evaluating between epithelial integrity activation. Duodenal biopsies were obtained from 24 FD patients 37 healthy controls. The ultrastructure eosinophils was analyzed transmission electron microscopy....
Emerging science shows that probiotic intake may impact stress and mental health. We investigated the effect of a 6-week intervention with Bifidobacterium longum (BL) NCC3001 (1 × 1010 CFU/daily) on stress-related psychological physiological parameters in 45 healthy adults mild-to-moderate using randomized, placebo-controlled, two-arm, parallel, double-blind design. The main results showed supplementation significantly reduced perceived improved subjective sleep quality score compared to...